Physician
Allergy & Immunology
Dr. James J. Mond, MD
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James J. Mond works in the field of Allergy & Immunology. He received 2 awards: "Elected Member" and "Most Compassionate Doctor". James Mond has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro.'
Publications
- A novel tetrameric gp350(1-470) as a potential Epstein-Barr virus vaccine.
- A novel synthetic (poly)glycerolphosphate-based anti-staphylococcal conjugate vaccine.
- A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis.
- Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice.
- Phase 1/2 double-blind, placebo-controlled, dose escalation, safety, and pharmacokinetic study of pagibaximab (BSYX-A110), an antistaphylococcal monoclonal antibody fo...
- Safety and pharmacokinetics of a chimerized anti-lipoteichoic acid monoclonal antibody in healthy adults.
- The multifunctional role of antibodies in the protective response to bacterial T cell-independent antigens.
- Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model.
- Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus.
- The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin.
- Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal co...
- Identification of antigenic components of Staphylococcus epidermidis expressed during human infection.
- Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.
- The critical DNA flanking sequences of a CpG oligodeoxynucleotide, but not the 6 base CpG motif, can be replaced with RNA without quantitative or qualitative changes i...
- Extended nasal residence time of lysostaphin and an anti-staphylococcal monoclonal antibody by delivery in semisolid or polymeric carriers.
- Lysostaphin-coated catheters eradicate Staphylococccus aureus challenge and block surface colonization.
- Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections.
- Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant.
- Proliferative assays for B cell function.
- Lysostaphin disrupts Staphylococcus aureus and Staphylococcus epidermidis biofilms on artificial surfaces.
- Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model.
- Improved pharmacokinetics and reduced antibody reactivity of lysostaphin conjugated to polyethylene glycol.
- Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae.
- In vitro antibody production.
- B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae.
- T(h)1 versus T(h)2 cytokine profile determines the modulation of in vitro T cell-independent type 2 responses by IL-4.
- B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms.
- Enhanced and sustained activation of human B cells by anti-immunoglobulin conjugated to the EBV glycoprotein gp350.
- Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for use in protein-polysaccharide conjugate vaccines and immunolo...
- Modulation of B-lymphocyte and NK cell activities by glycoinositolphospholipid purified from Trypanosoma cruzi.
- Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated coun...
- In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions.
- Heterogeneity in the ability of cytotoxic murine NK cell clones to enhance Ig secretion in vitro.
- Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro.
- Characterization of early activation events in cord blood B cells after stimulation with T cell-independent activators.
- Enhanced protective antibody responses to PspA after intranasal or subcutaneous injections of PspA genetically fused to granulocyte-macrophage colony-stimulating facto...
- Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion.
- Restoration of T cell-independent type 2 induction of Ig secretion by neonatal B cells in vitro.
- Prospects for vaccines during pregnancy and in the newborn period.
- A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens.
- IFN-gamma is a potent inducer of Ig secretion by sort-purified murine B cells activated through the mIg, but not the CD40, signaling pathway.
- IL-10 selectively regulates murine Ig isotype switching.
- Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological r...
- Superstimulatory influenza virus and highly organized BCR-ligands act synergistically on B cell activation.
- Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type II antigens.
- T cell independent antigens.
- IL-3 and granulocyte-macrophage colony-stimulating factor strongly induce Ig secretion by sort-purified murine B cell activated through the membrane Ig, but not the CD...
- PKC activity and protein phosphorylation in regulation of sIg mediated B cell activation.
- Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A ...
- T cell-independent antigens type 2.
- Inhibition of LPS-mediated cell activation in vitro and in vivo by gangliosides.
- Enhanced immunogenicity of protein-dextran conjugates: I. Rapid stimulation of enhanced antibody responses to poorly immunogenic molecules.
- Treatment with dextran-conjugated anti-IgD delays the development of autoimmunity in MRL-lpr/lpr mice.
- B lymphocyte immunoglobulin receptor desensitization is downstream of tyrosine kinase activation.
- An in vitro model for T cell-independent induction of humoral immunity. A requirement for NK cells.
- Natural killer cells induce activated murine B cells to secrete Ig.
- Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis.
- IL-10 inhibits T cell-independent but not T cell-dependent responses in vitro.
- Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells.
- Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.
- Dextran-conjugated anti-IgD antibodies inhibit T cell-mediated IgE production but augment the synthesis of IgM and IgG.
- Towards a comprehensive view of immunoglobulin class switching.
- Comparison of tyrosine kinase activation by mitogenic and nonmitogenic anti-IgD antibodies.
- Lymphokine control of type 2 antigen response. IL-10 inhibits IL-5- but not IL-2-induced Ig secretion by T cell-independent antigens.
- Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.
- Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation.
- Cholera toxin promotes the proliferation of anti-mu antibody-prestimulated human B cells.
- Biochemical analysis of the immune B cell defect in xid mice.
- Cross-linkage of Ly-6A/E induces Ca2+ translocation in the absence of phosphatidylinositol turnover and mediates proliferation of normal murine B lymphocytes.
- Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.
- IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4.
- Identification of a prominent 85-kDa cAMP-dependent phosphoprotein associated with late G1 phase in mitogen-stimulated B lymphocytes.
- Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C.
- Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.
- Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence.
- Polyclonal activation of the murine immune system by an antibody to IgD. X. Evidence that the precursors of IgG1-secreting cells are newly generated membrane IgD+B cel...
- cAMP-independent effects of cholera toxin on B cell activation. I. A possible role for cell surface ganglioside GM1 in B cell activation.
- IL4 is not required for proliferative responses in B cells stimulated by anti-IgD-dextran conjugates even under limiting conditions of cell-cell interaction.
- Activation of human B lymphocytes by nanogram concentrations of anti-IgM-dextran conjugates.
- Absence of demonstrable phospholipid turnover in B cells stimulated by low mitogenic concentrations of dextran-anti-immunoglobulin conjugates.
- Protein kinase C activation in B cells by indolactam inhibits anti-Ig-mediated phosphatidylinositol bisphosphate hydrolysis but not B cell proliferation.
- 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice.
- Different patterns of inositol polyphosphate production are seen in B lymphocytes after cross-linking of sIg by anti-Ig antibody or by a multivalent anti-Ig antibody d...
- Surface immunoglobulin-mediated B-cell activation in the absence of detectable elevations in intracellular ionized calcium: a model for T-cell-independent B-cell activ...
- Neonatal suppression with anti-Ia antibody. III. In vivo responses to the type 2 antigen TNP-Ficoll.
- The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulate...
- Identification of numatrin, the nuclear matrix protein associated with induction of mitogenesis, as the nucleolar protein B23. Implication for the role of the nucleolu...
- Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation.
- B-lymphocyte activation mediated by anti-immunoglobulin antibody in the absence of protein kinase C.
- A role for IFN-gamma and NK cells in immune responses to T cell-regulated antigens types 1 and 2.
- B-cell activation stimulated by monoclonal anti-Lyb2.1 antibody is mediated through a receptor distinct from the BSF-1 receptor.
- "Numatrin," a nuclear matrix protein associated with induction of proliferation in B lymphocytes.
- Comparison of the calcium requirement for the induction and maintenance of B cell class II molecule expression and for B cell proliferation stimulated by mitogens and ...
- Synergistic effects of the xid gene in X chromosome congenic mice. I. Inability of C3.CBA/N mice to respond to thymus-dependent antigens in adoptive transfer assays.
- Production of BSF-1 during an in vivo, T-dependent immune response.
- In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes.
- Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors.
- Interferon-gamma inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells.
- B cell stimulatory factor 1 (BSF-1) prepares resting B cells to enter S phase in response to anti-IgM and lipopolysaccharide.
- In vitro and in vivo B lymphocyte-activating properties of monoclonal anti-delta antibodies. I. Determinants of B lymphocyte-activating properties.
Schools
New York University School Of Medicine
Doctors Specialties
- Rheumatology
- Allergy
- Immunology
Accepted Insurances
Awards
- Elected Member
- Most Compassionate Doctor
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