Professor of Ophthalmology, Johns Hopkins University School of Medicine; Robert Bond Welch Professor
Ophthalmology
Dr. James Handa, MD
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James Handa is an expert in the field of Ophthalmology. He graduated from Perelman School of Medicine at the University of Pennsylvania. He received awards:"America's Top Doctors", "CMS Meaningful Use Stage 1 Certification", "America's Top Doctors for Cancer", "Top Doctors:Baltimore Area", "Top Doctors:Washington-Baltimore", "Super Doctor" and "Fellow (FAAO)". James Handa is a published doctor. He published 99 publications, including: 'Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Lysosomes: Regulators of autophagy in the Retinal pigmented epithelium.
- Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society ...
- Force-Sensing Microneedle for Assisted Retinal Vein Cannulation*
- Mice that produce ApoB100 lipoproteins in the RPE do not develop drusen yet are still a valuable experimental system.
- Increased Lipocalin-2 in the Retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response.
- Development of A Miniaturized 3-DOF Force Sensing Instrument for Robotically Assisted Retinal Microsurgery and Preliminary Results.
- Motorized Force-Sensing Micro-Forceps with Tremor Cancelling and Controlled Micro-Vibrations for Easier Membrane Peeling.
- Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells.
- Nrf2 signaling modulates cigarette smoke-induced complement activation in Retinal pigmented epithelial cells.
- AUTOMATED IMAGE ALIGNMENT AND SEGMENTATION TO FOLLOW PROGRESSION OF GEOGRAPHIC ATROPHY IN AGE-RELATED Macular DEGENERATION.
- Lysosomal-mediated waste clearance in Retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.
- A Novel Dual Force Sensing Instrument with Cooperative Robotic Assistant for VitreoRetinal Surgery.
- NRF2 plays a protective role in Diabetic retinopathy in mice.
- Role of UPR dysregulation in oxidative injury of Retinal pigment epithelial cells.
- Hypoxic Retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
- Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related Macular degeneration.
- Vascular disrupting agent for neovascular age related Macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate.
- A role for Jag2 in promoting uveal Melanoma dissemination and growth.
- A FORCE-SENSING MICROSURGICAL INSTRUMENT THAT DETECTS FORCES BELOW HUMAN TACTILE SENSATION.
- Evaluation of a Micro-Force Sensing Handheld Robot for VitreoRetinal Surgery.
- Human RPE cells express the FGFR2IIIc and FGFR3IIIc splice variants and FGF9 as a potential High affinity ligand.
- The expression of native and cultured RPE grown on different matrices.
- Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human Retinal pigment epithelium.
- Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the D-galactose-treated mouse.
- Expression of cell cycle related proteins in a rapidly growing uveal malignant Melanoma.
- Similarity of mRNA phenotypes of morphologically normal Macular and peripheral retinal pigment epithelial cells in older human eyes.
- Systemic non-Hodgkin B-cell lymphoma encountered as a vanishing Choroidal mass.
- Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor.
- Light-induced oxidative stress in Choroidal endothelial cells in mice.
- Keratoprosthesis in High-risk pediatric corneal transplantation: first 2 cases.
- New molecular histopathologic insights into the pathogenesis of age-related Macular degeneration.
- Advanced glycation end products and receptors in Fuchs' dystrophy corneas undergoing Descemet's stripping with endothelial keratoplasty.
- The impact of optical coherence tomography on surgical decision making in epiretinal membrane and vitreoMacular traction.
- Impact of optical coherence tomography on surgical decision making for epiretinal membranes and vitreoMacular traction.
- Oxidized low density lipoproteins induce a pathologic response by Retinal pigmented epithelial cells.
- Recent trends in the management of rhegmatogenous Retinal detachment.
- Macular retinal detachment in Hallermann-Streiff syndrome.
- Improved systemic chemOtherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision.
- Chronic cigarette smoke causes oxidative damage and apoptosis to Retinal pigmented epithelial cells in mice.
- Senescence associated beta galactosidase activity in human Retinal pigment epithelial cells exposed to mild hyperoxia in vitro.
- Oxidized Low-Density-Lipoprotein-Induced Injury in Retinal Pigment Epithelium Alters Expression of the Membrane Complement Regulatory Factors CD46 and CD59 through Exo...
- Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells.
- Comparison of retrobulbar and sub-Tenon''s capsule injection of local anesthetic in vitreoRetinal surgery.
- Advanced glycation endproduct-induced aging of the retinal pigment epithelium and Choroid: a comprehensive transcriptional response.
- CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.
- Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related Macular degeneration.
- Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
- Knockdown of FABP5 mRNA decreases cellular cHolesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells.
- Towards Robot-Assisted VitreoRetinal Surgery: Force-Sensing Micro-Forceps Integrated with a Handheld Micromanipulator.
- A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.
- Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration.
- Retinal basement membrane abnormalities and the Retinopathy of Alport syndrome.
- The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas.
- Apolipoprotein B100 secretion by cultured ARPE-19 cells is modulated by alteration of cHolesterol levels.
- Retinal vessel cannulation with an image-guided handheld robot.
- Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the Retinal pigmented epithelium of the rat.
- A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye.
- Nrf2 has a protective role against neuronal and capillary Degeneration in retinal ischemia-reperfusion injury.
- Lipids, lipoproteins, and age-related Macular degeneration.
- Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nonDiabetics).
- Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.
- Emerging treatments for Choroidal metastases.
- Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets.
- Notch Signaling Promotes Growth and Invasion in Uveal Melanoma.
- Advanced glycation endproduct changes to Bruch's membrane promotes lipoprotein retention by lipoprotein lipase.
- Micro-force sensing in robot assisted membrane peeling for vitreoRetinal surgery.
- A sub-millimetric, 0.25 mN resolution fully integrated fiber-optic force-sensing tool for Retinal microsurgery.
- Single fiber optical coherence tomography microsurgical instruments for computer and robot-assisted Retinal surgery.
- Cooperative robot assistant for Retinal microsurgery.
- Different effects of angiopoietin-2 in different Vascular beds: new vessels are most sensitive.
- Age and topographic variation of insulin-like growth factor-binding protein 2 in the human rpe.
- Oxidative stress--induced single-strand breaks in chromosomal telomeres of human Retinal pigment epithelial cells in vitro.
- Induction of an aging mRNA Retinal pigment epithelial cell phenotype by matrix-containing advanced glycation end products in vitro.
- Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells.
- Senescence-associated beta-galactosidase histochemistry for the primate eye.
- Beta-galactosidase histochemistry and telomere loss in senescent Retinal pigment epithelial cells.
- Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.
- Distribution of the collagen IV isoforms in human Bruch''s membrane.
- A novel mutation in intron 11 of the COL2A1 gene in a patient with type 1 Stickler Syndrome.
- The expression of native and cultured human Retinal pigment epithelial cells grown in different culture conditions.
- The advanced glycation endproduct pentosidine induces the expression of PDGF-B in human Retinal pigment epithelial cells.
- The use of hyperoxia to induce chronic mild oxidative stress in RPE cells in vitro.
- Density-dependent expression of FGF-2 in response to oxidative stress in RPE cells in vitro.
- An optimized protocol for first strand cDNA synthesis from laser capture microdissected tissue.
- Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation.
- Histologic localization of indocyanine green dye in aging primate and human ocular tissues with clinical angiographic correlation.
- Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the ag...
- A phase I trial of stereotactic external beam radiation for subfoveal choroidal neovascular membranes in age-related Macular degeneration.
- The mRNA phenotype of a human RPE cell line at replicative senescence.
- Induction of telomere shortening and replicative senescence by cryopreservation.
- Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation.
- The role of vitrectomy in rhegmatogenous Retinal detachment.
- Early treatment of posterior Retinopathy of prematurity: a controlled trial.
- The antiproliferative effect of a transferrin-toxin on human Retinal pigment epithelial cells and rabbit fibroblasts.
- Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil.
- Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related Macular degeneration (AMD).
- Transferrin-ricin A chain toxin limits the development of experimental proliferative vitreoRetinopathy.
- Lightning maculopathy. A case report.
Schools
University Of Pennsylvania School Of Medicine
Graduate Hospital
Wills Eye Hospital
Duke Eye Center
University Of Southern California School Of Med
Procedures Preformed
- Cataract Removal Surgery
- Coreoplasty
- Cornea Transplant
- Destruction of Lesion of Retina and Choroid
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Conditions Treated
- Age-Related Macular Degeneration
- Aphakia and Other Disorders of Lens
- Benign Neoplasm of Choroid
- Benign Neoplasm of Eye
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Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- America's Top Doctors for Cancer
- Top Doctors:Baltimore Area
- Top Doctors:Washington-Baltimore
- Super Doctor
- Fellow (FAAO)
Education
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Wills Eye Hospital -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Howard County General Hospital -
Johns Hopkins Hospital
Drug Facts
| NPI NUMBER | 1811946874 | |
| NPPES Provider LastName | HANDA | |
| NPPES Provider FirstName | JAMES | |
| NPPES Provider ZIPCode | 212870005 | |
| NPPES Provider State | MD | |
| Specialty Description | Ophthalmology | |
| Total Claim Count | 22.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1811946874 |
| Last Name Of The Provider | HANDA |
| First Name Of The Provider | JAMES |
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