Lawrence J. Henderson Professor of Pediatrics, Boston Children's Hospital
Endocrinology
Dr. Isaac S. Kohane, MD
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Doctor Isaac S. Kohane, MD practices Endocrinology. He graduated from Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care He received 1 awards: "Elected Member". Doctor Isaac S. Kohane, MD is also a published doctor. He has 101 paper published. The most recent paper is: SMART on FHIR: a standards-based, interoperable apps platform for electronic health records.
Publications
- SMART on FHIR: a standards-based, interoperable apps platform for electronic health records.
- SMART on FHIR Genomics: facilitating standardized clinico-genomic apps.
- A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.
- Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases.
- Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.
- Mode of Childbirth and Long-Term Outcomes in Women with Inflammatory Bowel Diseases.
- Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.
- An Electronic Health Records Study of Long-Term Weight Gain Following Antidepressant Use.
- An Autism Case History to Review the Systematic Analysis of Large-Scale Data to Refine the Diagnosis and Treatment of Neuropsychiatric Disorders.
- Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative.
- Finding the Missing Link for Big Biomedical Data.
- Reducing False Positive Incidental Findings with Ensemble Genotyping and Logistic Regression-Based Variant Filtering Methods.
- Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture.
- Medicine's Uncomfortable Relationship With Math: Calculating Positive Predictive Value.
- Population-Level Evidence for an Autoimmune Etiology of Epilepsy.
- Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases.
- Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease.
- Prioritizing Disease-Linked Variants, Genes, and Pathways with an Interactive whole Genome Analysis Pipeline.
- Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder.
- Comorbidity Clusters in Autism Spectrum Disorders: An Electronic Health Record Time-Series Analysis.
- iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.
- Lipid and lipoprotein levels and trend in rheumatoid arthritis compared to the general population.
- Association Between Reduced Plasma 25-hydroxy Vitamin D and Increased Risk of Cancer in Patients with Inflammatory Bowel Diseases.
- Can we measure autism?
- Comparative RNA editing in autistic and neurotypical cerebella.
- Opportunities for genomic clinical decision support interventions.
- Secondary Use of Health Information: Are We Asking the Right Question?
- Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn's Disease.
- A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data.
- The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future.
- Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid art...
- Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy.
- Peripheral blood gene expression signature differentiates children with autism from unaffected siblings.
- Automating the study of population variation of electrocardiographic features.
- Improving Case Definition of Crohn's Disease and Ulcerative Colitis in Electronic Medical Records Using Natural Language Processing: A Novel Informatics Approach.
- Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid ar...
- Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease.
- QT interval and antidepressant use: a cross sectional study of electronic health records.
- Apps to display patient data, making SMART available in the i2b2 platform.
- Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis.
- Structural, Genetic, and Functional Signatures of Disordered Neuro-Immunological Development in Autism Spectrum Disorder.
- Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders.
- Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: ...
- Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: A diffusion tensor imaging study using legacy data.
- Making sense out of massive data by going beyond differential expression.
- Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease.
- The SMART Platform: early experience enabling substitutable applications for electronic health records.
- Quantifying the White Blood Cell Transcriptome as an accessible window to the Multi-Organ Transcriptome.
- Technical desiderata for the integration of genomic data into Electronic Health Records.
- A translational engine at the national scale: informatics for integrating biology and the bedside.
- No small matter: qualitatively distinct challenges of pediatric genomic studies.
- Differential Effects of the Huntington's disease CAG Mutation in Striatum and Cerebellum are Quantitative not Qualitative.
- HD CAG-correlated gene expression changes support a simple dominant gain of function.
- Marco Ramoni: an appreciation of academic achievement.
- Assessing the reproducibility of asthma genome-wide association studies in a general clinical population.
- Counterpoint: Do not opine before it's time.
- Inferring cell cycle feedback regulation from gene expression data.
- Cambogin Is Preferentially Cytotoxic to Cells Expressing PDGFR.
- DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases.
- Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.
- Correction: DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases.
- Drug target-gene signatures that predict teratogenicity are enriched for developmentally related genes.
- Multidimensional results reporting to participants in genomic studies: getting it right.
- Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records.
- Does collocation inform the impact of collaboration?
- Indivo x: developing a fully substitutable personally controlled health record platform.
- Transcriptomic analysis of human lung development.
- High throughput single cell bioinformatics.
- The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories.
- High-throughput single cell arrays as a novel tool in biopreservation.
- Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records.
- Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients".
- No small change for the health information economy.
- Expression profiles of the mouse lung identify a molecular signature of time-to-birth.
- A practical platform for blood biomarker study by using global gene expression profiling of peripheral whole blood.
- Tissue and process specific microRNA-mRNA co-expression in mammalian development and malignancy.
- Tectonic shifts in the health information economy.
- Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
- Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells.
- Characterization of patients who suffer asthma exacerbations using data extracted from electronic medical records.
- Distinctive patterns of microRNA expression in primary muscular disorders.
- Genomic expression pathways associated with brain injury after cardiopulmonary bypass.
- A self-scaling, distributed information architecture for public health, research, and clinical care.
- An epidemiological network model for disease outbreak detection.
- Network-based analysis of affected biological processes in type 2 diabetes models.
- Medicine. Reestablishing the researcher-patient compact.
- Evidence of spatially bound gene regulation in Mus musculus: decreased gene expression proximal to microRNA genomic location.
- The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction.
- Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.
- Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin.
- Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.
- A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.
- Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model.
- The incidentalome: a threat to genomic medicine.
- Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development.
- Effect of acute aldosterone administration on gene expression profile in the heart.
- Creation and implications of a phenome-genome network.
- Integration of the personally controlled electronic medical record into regional inter-regional data exchanges: a national demonstration.
- Mapping tool for maintaining vocabulary relationships.
- Health-information altruists--a potentially critical resource.
Schools
Boston University School Of Medicine
Children39s Hospital
Doctors Specialties
- Pediatric Endocrinology
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Boston Children's Hospital -
Boston University School of Medicine
Hospital
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Boston Children's Hospital
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