Physician

Nephrology

Dr. Irwin Singer practices Nephrology. He went to medical school at Albert Einstein College of Medicine at Jacobi Medical Center. He received awards:"Elected Member". Irwin Singer has written publications. He has 41 publications published with PubMed. The lastest paper is: 'Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease.'

Publications

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• 11?-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
• Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis.
• Effects of certain antiorgan sera on experimental malaria and trypanosomiasis in mice.
• Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
• Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.
• Interleukin 1 beta is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes.
• Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in...
• Scanning electron microscopy of focal contacts on the substratum attachment surface of fibroblasts adherent to fibronectin.
• Recombinant human interleukin-1 beta-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid.
• Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 i...
• Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
• 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.
• The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno...
• 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.
• Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.
• In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblas...
• Localization of the fibronexus at the surface of granulation tissue myofibroblasts using double-label immunogold electron microscopy on ultrathin frozen sections.
• Extracellular matrix-cytoskeletal interactions in rheumatoid arthritis. I. Immunoelectron microscopic analysis of the fibronexus at the adhesive surface of normal porc...
• Hydroxymethylglutaryl-coenzyme A reductase exhibits graded distribution in normal and mevinolin-treated ileum.
• Extensive laminin and basement membrane accumulation occurs at the onset of bleomycin-induced rodent pulmonary fibrosis.
• The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.
• Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.
• Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte ...
• Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.
• Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
• Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.
• Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.
• Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase induce reductase accumulation and altered lamellar bodies in rat forestomach keratinocytes.
• Extracellular matrix fibers containing fibronectin and basement membrane heparan sulfate proteoglycan coalign with focal contacts and microfilament bundles in stationa...
• A tacrolimus-related immunosuppressant with reduced toxicity.
• Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease.
• Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences.
• Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.
• VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
• CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.
• Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
• CCR5 blockade modulates inflammation and alloimmunity in primates.
• Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium.
• Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.
• A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation.

Doctors Specialties

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• Internal Medicine
• Nephrology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Massachusetts General Hospital
• Albert Einstein College of Medicine at Jacobi Medical Center
• Albert Einstein College of Medicine of Yeshiva University

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