Professor, Pediatrics, University of Washington School of Medicine
Pediatrics
Dr. Irwin D. Bernstein, MD
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Irwin Bernstein practices Pediatrics. Irwin Bernstein is a published MD as well. He has 42 publications published. The latest was: CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531.
Publications
- CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531.
- SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.
- Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric/adult AML: a report from the Children's Oncology Group and SWOG.
- AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
- Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
- Ex vivo expansion of human hematopoietic stem and progenitor cells.
- Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.
- Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.
- Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo ...
- Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
- Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.
- Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit.
- Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.
- E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
- Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.
- Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells ...
- Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
- Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus.
- Clinical strategies to enhance posttransplant immune reconstitution.
- ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2.
- The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation.
- CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzuma...
- Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1.
- FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia.
- 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remiss...
- Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia.
- Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells.
- Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence.
- Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells.
- Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity.
- The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
- The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.
- High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma:...
- Conditionally cleavable radioimmunoconjugates: a novel approach for the release of radioisotopes from radioimmunoconjugates.
- Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.
- Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia.
- Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute mye...
- Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.
- Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.
- High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma.
- CD33 as a target for selective ablation of acute myeloid leukemia.
Schools
New York University
Children39s Hospital Los Angeles
Chldns Hospital Med Center
Doctors Specialties
- Pediatrics
Accepted Insurances
Education
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Children's Hospital of Los Angeles
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