Professor of Medicine; Chief, Pulmonary, Critical Care and Sleep Medicine, National Jewish Health
Pulmonology
Dr. Irina Petrache, MD
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Irina Petrache works in the field of Pulmonology. She over the years received 2 awards: "Alumna" and "Elected Member". Irina Petrache is also a published doctor. She has 70 paper published. The most recent paper is: Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.
Publications
- Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.
- Neonatal Hyperoxic Lung Injury Favorably Alters Adult Right Ventricular Remodeling Response to Chronic Hypoxia Exposure.
- Plasma Sphingolipids Associated with COPD Phenotypes.
- Space Radiation Associated Lung Injury in a Murine Model.
- Human Adipose-derived Stem Cells Ameliorate Cigarette Smoke-induced Murine Myelosuppression via TSG-6.
- Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission.
- Overexpression of type VI collagen in neoplastic Lung tissues.
- Vertebral erosion: an uncommon complication of tracheal tubes.
- Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance.
- Loss of cystic fibrosis transmembrane conductance regulator impairs Lung endothelial cell barrier function and increases susceptibility to microvascular damage from ci...
- Selective endothelin-A receptor blockade attenuates endotoxin-induced Pulmonary hypertension and Pulmonary vascular dysfunction.
- Progress In Solving The Sex Hormone Paradox In Pulmonary Hypertension.
- HIV envelope protein gp120-induced apoptosis in Lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.
- Effects of lipid interactions on model vesicle engulfment by alveolar macrophages.
- MSPrep--Summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data.
- Smoking Exposure Induces Human Lung Endothelial Cells Adaptation to Apoptotic Stress.
- Alpha-1 Antitrypsin Modulates Lung Endothelial Cell Inflammatory Responses to TNF?
- Cigarette Smoke Exposure Inhibits Contact Hypersensitivity via the Generation of Platelet-Activating Factor Agonists.
- In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse Lungs.
- RTP801 is Required for Ceramide-Induced Cell-Specific Death in the Murine Lung.
- Cigarette Smoke-Induced CXCR3 Receptor Upregulation Mediates Endothelial Apoptosis.
- LC3 as a potential therapeutic target in hypoxia-induced Pulmonary hypertension.
- Conditioned media from adipose stromal cells limit lipopolysaccharide-induced Lung injury, endothelial hyperpermeability and apoptosis.
- Transient and Persistent Metabolomic Changes in Plasma following Chronic Cigarette Smoke Exposure in a Mouse Model.
- Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium.
- Ceramide synthases expression and role of ceramide synthase-2 in the Lung: insight from human Lung cells and mouse models.
- The involvement of sphingolipids in Chronic obstructive pulmonary diseases.
- Involvement of ceramide in cell death responses in the Pulmonary circulation.
- A dihydroceramide-based response to hypoxia.
- Mechanisms of Lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides.
- Two-Photon Imaging within the Murine Thorax without Respiratory and Cardiac Motion Artifact.
- Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced Emphysema in mice.
- Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.
- Lung disease associated with alpha1-antitrypsin deficiency.
- Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages.
- Adipose stem cell treatment in mice attenuates Lung and systemic injury induced by cigarette smoking.
- Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced Pulmonary injury and emphysema.
- Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in Emphysema.
- Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency.
- A monoclonal rat anti-mouse EMAP II antibody that functionally neutralizes pro- and mature-EMAP II in vitro.
- Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance.
- Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible Lung allografts.
- Mechanism of alpha-1 antitrypsin endocytosis by Lung endothelium.
- CFTR regulation of intracellular pH and ceramides is required for Lung endothelial cell apoptosis.
- Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
- Anti-type V collagen humoral immunity in Lung transplant primary graft dysfunction.
- Targeted induction of lung endothelial cell apoptosis causes Emphysema-like changes in the mouse.
- Tissue transglutaminase protects epithelial ovarian Cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.
- HIV associated Pulmonary emphysema: a review of the literature and inquiry into its mechanism.
- Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.
- Apoptotic sphingolipid signaling by ceramides in Lung endothelial cells.
- Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin.
- Role of lung maintenance program in the heterogeneity of lung destruction in Emphysema.
- alpha-1 antitrypsin inhibits caspase-3 activity, preventing Lung endothelial cell apoptosis.
- Ceramide causes Pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells.
- State of the art. Cellular and molecular mechanisms of alveolar destruction in Emphysema: an evolutionary perspective.
- A novel antiapoptotic role for alpha1-antitrypsin in the prevention of Pulmonary emphysema.
- Pulmonary ischemia induces lung remodeling and angiogenesis.
- Ceramide upregulation causes Pulmonary cell apoptosis and emphysema-like disease in mice.
- Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced Emphysema in mice.
- Central involvement of Rho family GTPases in TNF-alpha-mediated bovine Pulmonary endothelial cell apoptosis.
- The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability.
- Apoptosis and Emphysema: the missing link.
- Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine Pulmonary endothelial cell apoptosis.
- Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction.
- Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts.
- Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells.
- Protective effects of heme oxygenase-1 in acute Lung injury.
- Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages.
Schools
Universitatea De Medicina Si Farmacie Carol Davila Facultatea De Medicina
St Lukes Med Center
Johns Hopkins University
Procedures Preformed
- Ventilation Management
Conditions Treated
- Acidosis
- Chronic Pulmonary Heart Diseases (incl. Pulmonary Hypertension)
- Emphysema
- Interstitial Lung Disease
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
Awards
- Alumna
- Elected Member
Education
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Johns Hopkins University -
Carol Davila University of Medicine and Pharmacy
Hospital
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National Jewish Health
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1801851365 |
| Last Name Of The Provider | PETRACHE |
| First Name Of The Provider | IRINA |
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