Ian Reynolds MD - orthospine
Orthopaedic Surgery
Dr. Ian J. Reynolds, MD
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Reynolds practices Orthopaedic Surgery. He graduated from Indiana University School of Medicine. Indiana University School of Medicine is ranked 45/47 in Research/PrimaryCare. Dr. Ian J. Reynolds is a published doctor as well. He has 101 publications published. The latest was: Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. He accepts all Medicare patients.
Publications
- Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.
- Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.
- Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
- High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays.
- Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
- PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.
- Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
- Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production.
- Mitochondrial trafficking to synapses in cultured primary cortical neurons.
- Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.
- Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
- Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation.
- Synaptosomal dopamine uptake in rat striatum following controlled cortical impact.
- Fluctuations in mitochondrial membrane potential in single isolated brain mitochondria: modulation by adenine nucleotides and Ca2+.
- Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation.
- Mitochondrial stop and go: signals that regulate organelle movement.
- Mitochondrial trafficking in neurons: a key variable in neurodegeneration?
- PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS.
- Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release.
- Fluorescence detection of redox-sensitive metals in neuronal culture: focus on iron and zinc.
- Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.
- Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria.
- Glucose deprivation produces a prolonged increase in sensitivity to glutamate in cultured rat cortical neurons.
- Glutamate decreases mitochondrial size and movement in primary forebrain neurons.
- A reevaluation of neuronal zinc measurements: artifacts associated with high intracellular dye concentration.
- The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.
- Genetic control of the immune response to collagen by the major histocompatibility complex in the rat: I. Humoral responses to bovine and chick type II collagen.
- Apoptosis and the laws of thermodynamics.
- Identification of an immunodominant B-cell epitope in bovine type II collagen and the production of antibodies to type II collagen by immunization with a synthetic pep...
- Light and electron microscopic analysis of insulin binding sites on neurons in dissociated brain cell cultures.
- Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model.
- Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture.
- Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.
- Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures.
- Subcellular localization of glutamate-stimulated intracellular magnesium concentration changes in cultured rat forebrain neurons using confocal microscopy.
- Mitochondrial membrane potential and the permeability transition in excitotoxicity.
- Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels.
- Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists.
- The use of ligand binding in assays of NMDA receptor function.
- Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors.
- Glutamate-induced neuron death requires mitochondrial calcium uptake.
- High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations.
- Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor.
- Intracellular calcium and magnesium: critical determinants of excitotoxicity?
- Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the g...
- Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons.
- Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons.
- Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site.
- Alkalinization prolongs recovery from glutamate-induced increases in intracellular Ca2+ concentration by enhancing Ca2+ efflux through the mitochondrial Na+/Ca2+ excha...
- The role of intracellular Na+ and mitochondria in buffering of kainate-induced intracellular free Ca2+ changes in rat forebrain neurones.
- Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
- Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones.
- Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.
- Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons.
- NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro.
- Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death.
- Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons.
- Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.
- Localization of D1 dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy.
- Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure.
- Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture.
- Mechanisms of glutamate-stimulated Mg2+ influx and subsequent Mg2+ efflux in rat forebrain neurones in culture.
- Effect of neuroactive steroids on [3H]flumazenil binding to the GABAA receptor complex in vitro.
- Characterization of the effects of polyamines on the modulation of the N-methyl-D-aspartate receptor by glycine.
- Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents.
- Effects of pH on the actions of dizocilpine at the N-methyl-D-aspartate receptor complex.
- Studies on the effects of several pentamidine analogues on the NMDA receptor.
- (-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyri...
- Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain.
- Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc.
- Calcium antagonist receptors.
- [3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites.
- [3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites.
- Multiple sites for the regulation of the N-methyl-D-aspartate receptor.
- 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.
- Muscarinic agonists cause calcium influx and calcium mobilization in forebrain neurons in vitro.
- Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
- Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo.
- Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues.
- NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
- Physiological and pharmacological correlates of calcium antagonist receptors.
- Calcium antagonist receptors. Clinical and physiological relevance.
- Brain voltage-sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA.
- Calcium-antagonist drugs. Receptor interactions that clarify therapeutic effects.
- Synthesis and bioactivity of a new class of rigid glutamate analogues. Modulators of the N-methyl-D-aspartate receptor.
- Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.
- Role of lipid solubility in the interaction of drugs with the N-methyl-D-aspartate receptor.
- Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
- Oxygen free radicals regulate NMDA receptor function via a redox modulatory site.
- Allosteric modulation of N-methyl-D-aspartate receptors.
- Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor.
- Modulation of NMDA receptor responsiveness by neurotransmitters, drugs and chemical modification.
- Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons.
- Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex.
- Effects of nicotinic agonists on the NMDA receptor.
- The spider toxin, argiotoxin636, binds to a Mg2+ site on the N-methyl-D-aspartate receptor complex.
- Regional variations in [3H]MK801 binding to rat brain N-methyl-D-aspartate receptors.
- 1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo.
- Modulation of NMDA excitotoxicity by redox reagents.
- 1,5-(Diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site.
Schools
Indiana University School Of Medicine
Methodist Hospital
Ochsner Fdn
Indiana University
Procedures Preformed
- Achilles Tendon Rupture Repair
- ACL (Anterior Cruciate Ligament) Surgery
- All Shoulder or Elbow Replacement Procedures
- Ankle Arthroscopy
- View All
Doctors Specialties
- Adult Orthopedic Surgery
- Adult Reconstructive Orthopedic Surgery
- Hand and Upper Extremity Surgery
- Orthopedic Arthroscopy
- Orthopedic Fracture Care
- Orthopedic Hand Surgery
- Orthopedic Hip Surgery
- Orthopedic Knee Surgery
- Orthopedic Neck Surgery
- Orthopedic Spine Surgery
- Orthopedic Sports Medicine
- Orthopedic Surgery
- Orthopedics
- Reconstructive Orthopedic Surgery
- Sports Medicine
- Sports Medicine Orthopedic Joint Reconstruction
- Orthopaedic Surgery
Accepted Insurances
Education
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Ochsner Clinic Foundation -
Indiana University School of Medicine
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