Professor of Neurological Surgery, University Pittsburgh
Neurosurgery
Dr. Ian F. Pollack, MD
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Pollack works in the field of Neurosurgery. He over the years received 7 awards: "America's Top Doctors", "America's Top Doctors for Cancer", "Pittsburgh Magazine", "Elected Member", "Fellow (FAANS)", "Fellow (FACS)" and "Top MD". Pollack is a published doctor. He has 100 papers published. The most current publication "Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the C..."
Publications
- Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central Nervous system tumors.
- Immunotherapy response assessment in neuro-oncology: a report of the RANO working group.
- Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium.
- Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Childr...
- A rare cause of reversible ophthalmoplegia: tension pneumocephalus with Brainstem compression.
- Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human gli...
- Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-i...
- Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade Gliomas.
- Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central Nervous system tumors: a PBTC study.
- The impact of age at surgery on long-term neuropsychological outcomes in sagittal craniosynostosis.
- Pseudoprogression of low-grade Gliomas after radiotherapy.
- Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfuncti...
- A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report†.
- The effects of whole vault cranioplasty versus strip craniectomy on long-term neuropsychological outcomes in sagittal craniosynostosis.
- Surgical treatment of sagittal synostosis by extended strip craniectomy: Cranial index, nasofrontal angle, reoperation rate, and a review of the literature.
- Ependymomas: development of immunotherapeutic strategies.
- Phase II study of cilengitide in the treatment of refractory or relapsed high-grade Gliomas in children: A report from the Children's Oncology Group.
- Bevacizumab (BVZ)-associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT-11): A Pediatric Brain Tumor Cons...
- Long-term survival of children less than six years of age enrolled on the CCG-945 phase III trial for newly-diagnosed high-grade glioma: A report from the Children's O...
- Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor- Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by E...
- Worsening or development of syringomyelia following Chiari I decompression.
- Challenges With Defining Response to Antitumor Agents in Pediatric Neuro-Oncology: A Report From the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Gr...
- Histological predictors of outcome in ependymoma are dependent on anatomic site within the central Nervous system.
- YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context.
- Management of Low-Grade Gliomas in Childhood.
- Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy.
- Bevacizumab-associated osteonecrosis of the wrist and knee in three pediatric patients with recurrent CNS tumors.
- Motexafin-gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a children's oncology group phase 2 study.
- Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome.
- Editorial: Brainstem gliomas.
- Optic pathway glioma as part of a constitutional mismatch-repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1.
- ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignan...
- A prognostic gene expression signature in infratentorial ependymoma.
- Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfuncti...
- Surgical Options for Pineal Region Tumors.
- A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and Brainstem gliomas: a Pediatric Brain T...
- Chronic granulomatous herpes encephalitis: a rare entity posing a diagnostic challenge.
- Identification of chemosensitivity nodes for vinblastine through small interfering RNA high- throughput screens.
- A phase 1 study of vinblastine in combination with carboplatin for children with low-grade Gliomas: a Children's Oncology Group phase 1 consortium study.
- Multidisciplinary management of childhood Brain tumors: a review of outcomes, recent advances, and challenges.
- Cranial vault remodeling for sagittal craniosynostosis in older children.
- Childhood Brain tumors: epidemiology, current management and future directions.
- MRI as a central component of clinical trials analysis in Brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC).
- Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine Gliomas: a report from the Children's Oncology Group.
- A phase II study of gefitinib and irradiation in children with newly diagnosed Brainstem gliomas: a report from the Pediatric Brain Tumor Consortium.
- Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine Gliomas.
- Temozolomide in the treatment of high-grade Gliomas in children: a report from the Children's Oncology Group.
- Fractures of the clivus and Traumatic diastasis of the central skull base in the pediatric population.
- Endoscopic port surgery for resection of lesions of the cerebellar peduncles: Technical note.
- Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.
- Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells...
- Parasagittal suture after strip craniectomy.
- Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway.
- Utility of cerebroSpinal fluid cytology in newly diagnosed childhood ependymoma.
- Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.
- Brain tumors across the age spectrum: biology, therapy, and late effects.
- A single-center experience with symptomatic postoperative calvarial growth restriction after extended strip craniectomy for sagittal craniosynostosis.
- Functional genomic analysis of glioblastoma multiforme through short interfering RNA screening: a paradigm for therapeutic development.
- Identification of survival genes in human glioblastoma cells by small interfering RNA screening.
- Stereotactic radiosurgery for pilocytic Astrocytomas part 2: outcomes in pediatric patients.
- Diagnosis and treatment of childhood Brain tumors: current perspectives.
- Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human gli...
- Multiple recurrent genetic events converge on control of histone lysine methylation in Medulloblastoma.
- Demineralized bone matrix and resorbable mesh bilaminate cranioplasty: a novel method for reconstruction of large-scale defects in the pediatric calvaria.
- Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent Medulloblastoma or germinoma.
- Expanded endoscopic endonasal resection of an olfactory Schwannoma.
- Tumors of the central Nervous system: clinical aspects, molecular mechanisms, unanswered questions, and future research directions.
- Diagnostic and therapeutic stratification of childhood Brain tumors: implications for translational research.
- A phase I trial of temozolomide and lomustine in newly diagnosed high-grade Gliomas of childhood.
- Extraventricular neurocytoma in neurofibromatosis Type 1: case report.
- Pathologist interobserver variability of histologic features in childhood Brain tumors: results from the CCG-945 study.
- Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intraCranial g...
- Phase I trial of VNP40101M (Cloretazine) in children with recurrent Brain tumors: a pediatric Brain tumor consortium study.
- Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors.
- Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central Nervous sys...
- Phase I trial of imatinib in children with newly diagnosed Brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report.
- Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients.
- Progression-associated genes in Astrocytoma identified by novel microarray gene expression data reanalysis.
- Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
- Albumin marks pseudopodia of Astrocytoma cells responding to hepatocyte growth factor or serum.
- Parental heat exposure and risk of childhood Brain tumor: a Children's Oncology Group study.
- Late rapid deterioration after endoscopic third ventriculostomy: additional cases and review of the literature.
- O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant Gliomas: results from the CCG-945 Cohort.
- Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responses.
- P53 pathway alterations are uncommon in childhood ependymomas.
- Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth.
- Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
- Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.
- Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis.
- Delivery of dendritic cells engineered to secrete IFN-alpha into central Nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on a...
- EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.
- Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies.
- Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric Brain tumor consortium study (...
- Molecular analysis of pediatric Brain tumors.
- Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13.
- Delivery of interferon-alpha transfected dendritic cells into central Nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines.
- Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study...
- ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric Brain stem glioma.
- Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the C...
Schools
Johns Hopkins University School of Medicine
University Pittsburgh School Med
Hospital Sick ChldnU LausanneU Uppsala
Procedures Preformed
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
Conditions Treated
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Injury
- Cranial Trauma
- Epilepsy
- View All
Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Pittsburgh Magazine
- Elected Member
- Fellow (FAANS)
- Fellow (FACS)
- Top MD
Education
-
University of Pittsburgh Medical Center
Hospital
-
UPMC Presbyterian Shadyside
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