Professor of Medicine (Cardiology) University of California San Diego
Cardiology
Dr. Hugh K. Hammond, MD
Hugh Hammond is an expert in the field of Cardiology. He studied medicine at Indiana University School of Medicine. Indiana University School of Medicine has a rank of 45 in research and a 47 in primary care Hugh K. Hammond is also a published MD. He has 85 paper published. The most recent paper is: Dissociation between regional dysfunction and beta-adrenergic receptor signaling in heart failure.
Publications
- Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice.
- Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.
- Intravenous AAV8 Encoding Urocortin-2 Provides Sustained Augmentation of Left Ventricular Function in Mice.
- Adenylyl cyclase 6 deletion increases mortality during sustained ?-adrenergic receptor stimulation.
- Gene transfer for congestive Heart failure: update 2013.
- Adenylyl Cyclase 6 Enhances NKCC2 Expression and Mediates Vasopressin-Induced Phosphorylation of NKCC2 and NCC.
- Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene Transfer.
- Prospects for gene transfer for clinical Heart failure.
- Improved function of the failing rat Heart by regulated expression of insulin-like growth factor I via intramuscular gene transfer.
- Gene therapy for myocardial infarction-associated congestive Heart failure: how far have we got?
- Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular funct...
- Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression.
- Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged Hearts.
- Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer.
- Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.
- Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
- Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded Heart.
- Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla.
- Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced Cardiomyopathy.
- Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.
- Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.
- beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.
- Galphaq reduces cAMP production by decreasing Galphas protein abundance.
- Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
- Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic Heart in mice.
- Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.
- Skeletal muscle-derived stem cell transplantation: angiogenesis is required for improved left ventricular function.
- New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive Heart failure therapy.
- Cell-based GATA4 cardiac gene transfer using cell-penetrating peptide.
- Adenylylcyclase gene transfer increases function of the failing Heart.
- Adenylyl cyclase gene transfer in Heart failure.
- Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.
- Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction.
- IntraCoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus.
- Signal peptide increases the efficacy of angiogenic gene transfer for treatment of myocardial ischemia.
- Why FRET? Focus on "beta-Adrenergic and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes using a FRET-based biosensor".
- Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in Cardiomyopathy.
- Nitroprusside increases gene transfer associated with intraCoronary delivery of adenovirus.
- Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
- IntraCoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure.
- Indirect intraCoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice.
- Increased regional function and perfusion after intraCoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data.
- Angiotensin receptor blockade improves myocardial beta-adrenergic receptor signaling in postinfarction left ventricular remodeling: a possible link between beta-adrene...
- Adenylyl cyclase increases survival in Cardiomyopathy.
- Angiogenic Gene Therapy (AGENT) trial in patients with stable Angina pectoris.
- IntraCoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity.
- Clinical trials in Coronary angiogenesis: issues, problems, consensus: An expert panel summary.
- Cardiac-directed adenylyl cyclase expression improves heart function in murine Cardiomyopathy.
- Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice.
- Beta-adrenergic receptors and receptor signaling in Heart failure.
- Dissociation between regional dysfunction and beta-adrenergic receptor signaling in Heart failure.
- Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes.
- Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist.
- Adenylyl cyclase and G protein receptor kinase expression during development of Heart failure.
- Subcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in Heart failure.
- Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits.
- Regional deficits of myocardial blood flow and function in left ventricular pacing-induced Heart failure.
- Altered beta-adrenergic receptor signaling in Heart failure, in vivo gene transfer via adeno and adeno-associated virus.
- IntraCoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart.
- Detection of regional left ventricular dysfunction in early pacing-induced Heart failure using ultrasonic integrated backscatter.
- Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine Heart.
- Force-frequency relations during Heart failure in pigs.
- Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine Hearts.
- Effects of dobutamine and arbutamine on regional myocardial function in a porcine model of myocardial ischemia.
- Beta-adrenergic receptors in Heart failure.
- Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of Chronic ep...
- Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive Heart failure.
- Mechanisms for myocardial beta-adrenergic receptor desensitization in Heart failure.
- Heart size and maximal cardiac output are limited by the pericardium.
- The role of the pericardium in conditioning the effects of physical training.
- Myocardial adrenergic denervation supersensitivity depends on a postreceptor mechanism not linked with increased cAMP production.
- A substantial proportion of cardiac Gs is not associated with the plasma membrane.
- Myocardial beta-adrenergic receptor expression and signal transduction after Chronic volume-overload hypertrophy and circulatory congestion.
- Myocardial characteristics of thyroxine stimulated hypertrophy. A structural and functional study.
- Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, Chronic dynamic exercise.
- Association of decreased myocardial beta-receptors and chronotropic response to isoproterenol and exercise in pigs following Chronic dynamic exercise.
- Increased myocardial beta-receptors and adrenergic responses in hyperthyroid pigs.
- Use of clinical data in predicting improvement in exercise capacity after cardiac rehabilitation.
- The physiologic sequelae of Chronic dynamic exercise.
- Normal and abnormal Heart rate responses to exercise.
- Noninvasive testing in the evaluation of myocardial ischemia: agreement among tests.
- Exercise testing for cardiorespiratory fitness.
- Radionuclide imaging correlatives of Heart rate impairment during maximal exercise testing.
- Preserved cardiac function despite marked impairment of cAMP generation.
Schools
Indiana University School of Medicine
Legacy Emanuel Med Center
Uc San Diego Med Center
Procedures Preformed
- Cardiac Imaging
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Ectasia
- Aortic Valve Disease
- View All
Doctors Specialties
- Cardiology
Accepted Insurances
Education
-
University of California San Diego -
Indiana University School of Medicine
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