Physician

Pulmonology

Howard Jacobs practices Pulmonology. He attended University of Maryland School of Medicine. University of Maryland School of Medicine has a rank of 37 in research and a 52 in primary care He over the years received 1 awards: "Top MD". Howard Jacobs is a published doctor and has 101 publications published. The lastest was: 'In vivo mitochondrial DNA-protein interactions in sea urchin eggs and embryos.'

Publications

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• Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter.
• Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.
• Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.
• Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
• Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila.
• Gene expression in a Drosophila model of mitochondrial Disease.
• Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.
• Human Heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.
• Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
• The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic.
• On modeling of mutation probabilities.
• No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.
• Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders.
• Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
• Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.
• A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.
• The 7472insC mtDNA mutation impairs 5' and 3' processing of tRNA(Ser(UCN)).
• Comparative genetics of functional trinucleotide tandem repeats in humans and apes.
• A prevalent POLG CAG microsatellite length allele in humans and African great apes.
• Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone.
• Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.
• The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.
• Very short repeats and coordinate induction of genes.
• The relationship between mRNA half-life and gene function in the yeast Saccharomyces cerevisiae.
• The study of cell-death proteins in the outer mitochondrial membrane by chemical cross-linking.
• Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6.
• Poly(A) RNA of the egg cytoplasm: structural resemblance to the nuclear RNA of somatic cells.
• In vivo mitochondrial DNA-protein interactions in sea urchin eggs and embryos.
• Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with...
• Do ribosomes regulate mitochondrial RNA synthesis?
• A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness.
• Transcripts of three mitochondrial genes in the RNA of sea urchin eggs and embryos.
• The dangers of extended PCR in the clinic.
• Structural similarities between a mitochondrially encoded polypeptide and a family of prokaryotic Respiratory toxins involved in plasmid maintenance suggest a novel me...
• Mitochondrial base prediction.
• Complete mtDNA sequence of a patient in a maternal pedigree with sensorineural deafness.
• Bilateral sensorineural hearing loss in members of a maternal lineage with mitochondrial point mutation.
• Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3.
• Characterization of a high-affinity binding site for a DNA-binding protein from sea urchin embryo mitochondria.
• Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
• Mitochondrial deafness.
• Apparent functional independence of the mitochondrial and nuclear transcription Systems in cultured human cells.
• Conserved tRNA gene cluster in starfish mitochondrial DNA.
• Mutually exclusive synthetic pathways for sea urchin mitochondrial rRNA and mRNA.
• Replication origins and pause sites in sea urchin mitochondrial DNA.
• Multisite oligonucleotide-mediated mutagenesis: application to the conversion of a mitochondrial gene to universal genetic code.
• Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes.
• Complete nucleotide sequences of the nuclear pseudogenes for cytochrome oxidase subunit I and the large mitochondrial ribosomal RNA in the sea urchin Strongylocentrotu...
• Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus.
• Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA.
• Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region.
• Expression of the nuclear gene encoding mitochondrial ATP synthase subunit alpha in early development of Drosophila and sea urchin.
• Heteroplasmic segregation associated with trisomy-9 in cultured human cells.
• Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL.
• Nuclear expression of mitochondrial genes implicated in human encephalomyopathies.
• Mitochondrial DNA--all things bad?
• Metazoan nuclear genes for mitoribosomal protein S12.
• Making mitochondrial mutants.
• A tRNA suppressor mutation in human mitochondria.
• Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.
• Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear backgr...
• Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.
• Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.
• Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA.
• Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus.
• No sex please, we''re mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.
• Long-extension PCR to detect deleted mitochondrial DNA molecules is compromized by technical artefacts.
• Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
• Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation.
• The mitochondrial inner membrane AAA metalloprotease family in metazoans.
• Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness fami...
• The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant.
• Analysis of the trinucleotide CAG repeat from the human mitochondrial DNA polymerase gene in healthy and Diseased individuals.
• In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells.
• Prominent mitochondrial DNA recombination intermediates in human Heart muscle.
• The np 3243 MELAS mutation: damned if you aminoacylate, damned if you don''t.
• Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states.
• Technical knockout, a Drosophila model of mitochondrial deafness.
• Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA.
• Molecular phenotype of the np 7472 deafness-associated mitochondrial mutation in osteosarcoma cell cybrids.
• Mitochondrial tRNALeu isoforms in Lung carcinoma cybrid cells containing the np 3243 mtDNA mutation.
• Rebuttal to Pak et al.: new data, chestnuts.
• Disorders of mitochondrial protein synthesis.
• The mitochondrial theory of aging: dead or alive?
• Response: The mitochondrial DNA replication bubble has not burst.
• The relationship between somatic mtDNA rearrangements, human Heart disease and aging.
• Premature ageing in mice expressing defective mitochondrial DNA polymerase.
• Mitochondrial DNA mutations in patients with postlingual, nonsyndromic hearing impairment.
• Nuclear genes and mitochondrial translation: a new class of genetic Disease.
• Wobble modification deficiency in mutant tRNAs in patients with mitochondrial Diseases.
• Mitochondrial Disease in flies.
• The Euromit meetings: an international platform for the understanding and combat of mitochondrial Disease.
• Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration.
• Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial Disease.
• Novel repetitive structures, deviant protein-encoding sequences and unidentified ORFs in the mitochondrial genome of the brachiopod Lingula anatina.
• The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcripti...
• Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.
• Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.
• Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.
• The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.

Schools

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• University of Maryland At Baltimore Professional Schools

• University MD School Med Hospital

Procedures Preformed

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• Bronchoscopy
• Thoracentesis
• Ventilation Management

Conditions Treated

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• Acidosis
• Acute Pharyngitis
• Asbestosis
• Asthma
• View All

Doctors Specialties

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• Critical Care Medicine
• Pulmonology

Accepted Insurances

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Awards

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• Top MD

Education

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• University of Maryland
• University of Maryland School of Medicine

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