Professor, Pediatrics-Children's Hospital, Harvard Medical School
Allergy & Immunology
Dr. Hans C. Oettgen, MD
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Hans Oettgen is an expert in the field of Allergy & Immunology. He studied medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 1 awards "Fellow (FAAAAI)". Hans C. Oettgen, MD is a published doctor and has 90 publications published. The lastest was: 'The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE.'
Publications
- Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy.
- Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells.
- IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum.
- A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom.
- An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis.
- Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.
- A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.
- Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.
- High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation.
- Mast cells and tumour necrosis factor alpha (TNF-α): Partners in crime in asthma pathogenesis.
- IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling.
- Anti-IgE in the treatment of allergic disorders in pediatrics.
- Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.
- In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.
- Adaptive immunity.
- Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
- Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
- Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
- Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.
- Novel presentation of Omenn syndrome in association with aniridia.
- IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation.
- IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
- Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
- Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection.
- TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation.
- Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation.
- Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus.
- The H1 histamine receptor regulates allergic lung responses.
- The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.
- Antigen-independent effects of immunoglobulin E.
- Immune sensitization in the skin is enhanced by antigen-independent effects of IgE.
- Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma.
- IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis.
- Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.
- Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma.
- CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation.
- Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation.
- Anti-IgE therapy: clinical utility and mechanistic insights.
- Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.
- In vivo localization of cloned IL-2-dependent T cells.
- Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
- Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production.
- Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3.
- Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.
- Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls.
- Comparison of leucine aminopeptidase from human lens, beef lens and kidney, and hog lens and kidney.
- Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome.
- IL-21 is the primary common gamma chain-binding cytokine required for human B-cell differentiation in vivo.
- The T cell receptor/T3 complex.
- The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits.
- The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides.
- The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
- Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1.
- The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.
- Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization.
- COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization.
- IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.
- Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.
- Epicutaneous sensitization with superantigen induces allergic skin inflammation.
- Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis.
- IgE regulation and roles in asthma pathogenesis.
- An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic der...
- Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts.
- CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice.
- IgE in asthma and atopy: cellular and molecular connections.
- SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
- The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE.
- Further biochemical studies of the human B-cell differentiation antigens B1 and B2.
- Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes.
- Purification, preliminary characterization, and immunological comparison of hog lens leucine aminopeptidase (EC 3.4.11.1) with hog kidney and beef lens aminopeptidases.
- Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils.
- A murine model of allergic rhinitis: studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin.
- Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts.
- Normal ranges for lymphocyte subsets in children.
- IgE regulates mouse basophil Fc epsilon RI expression in vivo.
- Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma.
- IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions.
- Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni.
- Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.
- Active anaphylaxis in IgE-deficient mice.
- A review of the structure and function of the T-cell receptor-T3 complex.
- The T-cell receptor-T3 complex and T-lymphocyte activation.
- A T3-like protein complex associated with the antigen receptor on murine T cells.
- Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.
- Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten.
- Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells.
- TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
- Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.
- Polyclonal IgE induces mast cell survival and cytokine production.
Schools
Harvard Medical School
Children39s Hospital
Doctors Specialties
- Pediatrics
- Allergy
- Immunology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- Fallon Community Health Plan
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Fellow (FAAAAI)
Education
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Boston Children's Hospital -
Harvard Medical School
Hospital
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Boston Children's Hospital
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