Physician
Medical Genetics
Dr. Gregory S. Barsh, MD
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Gregory Barsh practices Medical Genetics. He went to University of Washington School of Medicine. He received 1 awards: "Investigator Alumnus". Gregory S. Barsh is also published. He has 101 publications published. The lastest publication: "Characterization of Agouti-related protein binding to melanocortin receptors.'
Publications
- Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System.
- Recurrent evolution of melanism in South American felids.
- Modeling 3D Facial Shape from DNA.
- David R. Cox 1946-2013.
- Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.
- Genetic architecture of skin and eye color in an african-European admixed population.
- Levels of the mahogunin ring finger 1 e3 ubiquitin ligase do not influence prion disease.
- New ligands for melanocortin receptors.
- High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.
- Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
- Molecular and phenotypic analysis of Attractin mutant mice.
- Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts.
- Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3.
- Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition.
- Central nervous system control of food intake and body weight.
- Exclusion of melanocortin-1 receptor (mc1r) and agouti as candidates for dominant black in dogs.
- MC1R studies in dogs with melanistic mask or brindle patterns.
- The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes.
- The mouse ocular albinism 1 gene product is an endolysosomal protein.
- Mahogany/attractin: en route from phenotype to function.
- A biochemical function for attractin in agouti-induced pigmentation and obesity.
- Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein.
- Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.
- The long-range restriction map surrounding the mouse agouti locus reveals a disparity between physical and genetic distances.
- Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus.
- Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.
- Effects of the lethal yellow (Ay) mutation in mouse aggregation chimeras.
- Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.
- Inhibition of peripheral NF-kappaB activation by central action of alpha-melanocyte-stimulating hormone.
- Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.
- Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence.
- Molecular pharmacology of Agouti protein in vitro and in vivo.
- Secreted and membrane attractin result from alternative splicing of the human ATRN gene.
- Gene trap insertional mutagenesis in mice: new vectors and germ line mutations in two novel genes.
- Genetics of body-weight regulation.
- Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues.
- Regulation of mouse lens fiber cell development and differentiation by the Maf gene.
- Melanocortin 1 receptor variation in the domestic dog.
- Distribution of Mahogany/Attractin mRNA in the rat central nervous system.
- Characterization of Agouti-related protein binding to melanocortin receptors.
- Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area.
- Characterization of genes modulated during pheomelanogenesis using differential display.
- An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome.
- Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.
- Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.
- Equivalence in the genetic control of hindbrain segmentation in fish and mouse.
- Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
- Genetic studies of the mouse mutations mahogany and mahoganoid.
- Modulation of murine melanocyte function in vitro by agouti signal protein.
- Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin.
- Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
- Segmental regulation of Hoxb-3 by kreisler.
- Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease.
- Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans.
- Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam).
- Effects of recombinant agouti-signaling protein on melanocortin action.
- Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselecti...
- The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals.
- Isolation and characterization of a mouse homolog of the X-linked ocular albinism (OA1) gene.
- Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus.
- The genetics of pigmentation: from fancy genes to complex traits.
- Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
- A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein.
- Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.
- Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
- Biological insights through genomics: mouse to man.
- Differential spontaneous transformation in vitro of newly established mouse fibroblast lines carrying or lacking the viable yellow mutation (Avy) of the mouse agouti l...
- Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.
- Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.
- Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.
- Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.
- The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
- Association of Xmv-10 and the non-agouti (a) mutation explained by close linkage instead of causality.
- Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice.
- Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr).
- Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs.
- The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.
- Neomorphic agouti mutations in obese yellow mice.
- Structure and function of ASP, the human homolog of the mouse agouti gene.
- Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.
- Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated.
- Pigmentation, pleiotropy, and genetic pathways in humans and mice.
- Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.
- Peptide mapping of collagen chains using CNBr cleavage of proteins within polyacrylamide gels.
- Molecular mechanisms of disease in inherited disorders of collagen metabolism.
- Prenatal diagnosis of lethal perinatal osteogenesis imperfecta (OI type II).
- Molecular pathology in inherited disorders of collagen metabolism.
- Disorders of connective tissue metabolism as related to the skin.
- Type I osteogenesis imperfecta: a nonfunctional allele for pro alpha 1 (I) chains of type I procollagen.
- Reduced secretion of structurally abnormal type I procollagen in a form of osteogenesis imperfecta.
- The human growth hormone gene family: structure and evolution of the chromosomal locus.
- Altered secretion of type III procollagen in a form of type IV Ehlers-Danlos syndrome. Biochemical studies in cultured fibroblasts.
- Molecular mechanisms of connective tissue abnormalities in the Ehlers-Danlos syndrome.
- DNA and chromatin structure of the human alpha 1 (I) collagen gene.
- Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta.
- Construction, analysis, and application of a radiation hybrid mapping panel surrounding the mouse agouti locus.
- Expression of TAPA-1 in preimplantation mouse embryos.
- Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor.
- Systemically administered alpha-melanocyte-stimulating peptides inhibit NF-kappaB activation in experimental brain inflammation.
- The role of agouti-related protein in regulating body weight.
Schools
University of Washington
Doctors Specialties
- Clinical Genetics
- Medical Genetics
Accepted Insurances
Awards
- Investigator Alumnus
Education
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Harbor - UCLA Medical Center -
University of Washington School of Medicine
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