Professor, Internal Medicine, Washington University School of Medicine

Hematology

Gregory D. Longmore is an expert in the field of Hematology. He received awards:"Elected Member". Gregory Longmore is also published. He has 92 publications published. The lastest publication: "Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.'

Publications

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• Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.
• Transient SNAIL1 Expression is Necessary for Metastatic Competence in Breast Cancer.
• β-Catenin Serves as a Clutch between Low and High Intercellular E-Cadherin Bond Strengths.
• The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.
• The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
• ?-Actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.
• The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.
• Temporal and Spatial cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition predicts for human breast cancer recurrence.
• Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
• Context-dependent compensatory proliferation in epithelial homeostasis and tumorigenesis.
• Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements.
• LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
• The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia.
• LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.
• Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain.
• Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.
• Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms.
• Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.
• Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia.
• p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.
• The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
• {alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening.
• Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.
• Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor.
• The LIM protein LIMD1 influences osteoblast differentiation and function.
• CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells.
• Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
• The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.
• Actin stress fiber pre-extension in human aortic endothelial cells.
• Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.
• Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate.
• Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.
• The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling.
• Do cancer cells express functional erythropoietin receptors?
• The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.
• A unique role for Stat5 in recovery from acute anemia.
• The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.
• The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling comp...
• The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.
• Effects of recombinant hematopoietins on blood-loss anemia in mice.
• A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
• Ras protects Rb family null fibroblasts from cell death: a role for AP-1.
• The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.
• The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba.
• Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
• Structure, function, and activation of the erythropoietin receptor.
• Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia.
• Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity.
• Control of glycoprotein synthesis. The purification by preparative high voltage paper electrophoresis in borate of glycopeptides containing high mannose and complex ol...
• Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.
• The erythropoietin receptor: dimerization, activation, and tumorigenesis.
• Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6...
• Activation of the erythropoietin receptor and leukemia induction in mice.
• A simple method for hemoglobin measurement in cell culture system.
• The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
• Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent...
• Gamma -secretase inhibitors repress thymocyte development.
• Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell dev...
• Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals.
• Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.
• Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D.
• Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin.
• Abnormalities of cytokine receptor signalling contributing to Diseases of red blood cell production.
• Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
• Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes ...
• Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.
• Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.
• Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression.
• Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo.
• Cell surface organization of the erythropoietin receptor complex differs depending on its mode of activation.
• The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.
• Erythropoietin receptor mutations and Olympic glory.
• The erythropoietin receptor: its role in hematopoiesis and myeloproliferative Diseases.
• A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid prog...
• Expression of an activated erythropoietin or a colony-stimulating factor 1 receptor by pluripotent progenitors enhances colony formation but does not induce differenti...
• The conserved box 1 motif of cytokine receptors is required for association with JAK kinases.
• Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-fo...
• Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
• Lineage-restricted recruitment of immature hematopoietic progenitor cells in response to Epo after normal hematopoietic cell transfection with EpoR.
• Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.
• Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.
• Homodimerization and constitutive activation of the erythropoietin receptor.
• Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.
• Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltran...
• An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene.
• Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor.
• Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway.
• Differential regulation of apoptotic genes by Rb in human versus mouse cells.
• Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family members.
• A distinctive role for focal adhesion proteins in three-dimensional cell motility.
• A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi.

Schools

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• McGill University Faculty of Medicine

• New England Deaconess Hospital

• Brigham and Women39s Hospital

Conditions Treated

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• Hodgkin's Disease

Doctors Specialties

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• Medical Oncology
• Oncology
• Hematology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Brigham and Women's Hospital
• Beth Israel Deaconess Medical Center
• McGill University Faculty of Medicine

Hospital

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• Barnes-Jewish Hospital

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