Physician
Radiology
Dr. Gordon D. Brown, MD
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Doctor Gordon D. Brown, MD practices Radiology. He studied medicine at University of Utah School of Medicine. Gordon Brown is also a published physician. He has 101 publication published. The most recent publication is: Cytosolic phospholipase a2 and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation.
Publications
- Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages.
- The C type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.
- Expression of the hMICL in acute myeloid leukemia-a highly reliable disease marker at diagnosis and during follow-up.
- A co-ordinated interaction between CTCF and ER in breast cancer cells.
- Dectin-1 dependent IL-22 contributes to early innate lung defense against Aspergillus fumigatus.
- C-type lectin receptors and cytokines in fungal immunity.
- Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.
- Neutrophils produce IL-17A in a Dectin-1 and IL-23 dependent manner during invasive fungal infection.
- The role of Dectin-1 in the host defence against fungal infections.
- Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
- Breast Cancer Special Feature: Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells.
- Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin.
- Innate antifungal immunity: the key role of phagocytes.
- Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.
- In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.
- Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
- Screening for Ligands of C-Type Lectin-Like Receptors.
- Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.
- Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.
- Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.
- A CTCF-independent role for cohesin in tissue-specific transcription.
- Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.
- Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate.
- How fungi have shaped our understanding of mammalian immunology.
- Human dectin-1 deficiency and mucocutaneous fungal infections.
- From a blame culture to a just culture in health care.
- The Dectin-2 family of C-type lectins in immunity and homeostasis.
- Complement C3 plays an essential role in the control of opportunistic fungal infections.
- Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients.
- Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
- ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions.
- An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
- Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus.
- CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.
- Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis.
- Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.
- Generation of retroviral macrophage cDNA expression libraries and functional screening for surface receptors.
- The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model.
- Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses.
- beta-Glucans and dectin-1.
- Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.
- Sensing necrosis with Mincle.
- The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis.
- CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes.
- Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.
- Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and ...
- Genome-scale validation of deep-sequencing libraries.
- Immune recognition of Candida albicans beta-glucan by dectin-1.
- Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
- The role of the beta-glucan receptor Dectin-1 in control of fungal infection.
- Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.
- Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
- Dectin-1 is required for beta-glucan recognition and control of fungal infection.
- Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.
- Expression of functionally different dectin-1 isoforms by murine macrophages.
- Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysa...
- Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor.
- The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus.
- Glycosylation influences the lectin activities of the macrophage mannose receptor.
- Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.
- Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
- A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.
- Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1.
- A comprehensive survey of the genes involved in maturation and development of the rainbow trout ovary.
- Assessing communications effectiveness in meeting corporate goals of public health organizations.
- Executive management studies: the application of real-time science in health administration education.
- Microarray analyses identify molecular biomarkers of Atlantic salmon macrophage and hematopoietic kidney response to Piscirickettsia salmonis infection.
- Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages.
- Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition.
- Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leuk...
- Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes.
- Development and application of a salmonid EST database and cDNA microarray: data mining and interspecific hybridization characteristics.
- The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.
- The role of Dectin-1 in antifungal immunity.
- Design of a peer-to-peer telerehabilitation model.
- Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor.
- Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipop...
- Fungal beta-glucans and mammalian immunity.
- Dectin-1 mediates the biological effects of beta-glucans.
- Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies.
- The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages.
- Dectin-1 is a major beta-glucan receptor on macrophages.
- Cytosolic phospholipase a2α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation.
- The role of Syk/CARD9 coupled C-type lectins in antifungal immunity.
- The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
- Syk-coupled C-type lectins in immunity.
- The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice.
- C-type lectins, fungi and Th17 responses.
- Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways.
- C-type lectins and phagocytosis.
- Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs.
- Pattern recognition: recent insights from Dectin-1.
- The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors.
- Dectin-1 and its role in antifungal immunity.
- Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
- Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.
- Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan.
- Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo.
- Soluble Dectin-1 as a tool to detect beta-glucans.
- The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose.
Schools
University Of Utah School Of Medicine
UCLA Med Center
University Of Ut Med Center
Doctors Specialties
- Diagnostic Radiology
- Radiology
Accepted Insurances
Education
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UCLA Medical Center -
University of Utah -
University of Utah School of Medicine
Drug Facts
| NPI NUMBER | 1124192489 | |
| NPPES Provider LastName | BROWN | |
| NPPES Provider FirstName | GORDON | |
| NPPES Provider ZIPCode | 080802359 | |
| NPPES Provider State | NJ | |
| Specialty Description | Urology | |
| Total Claim Count | 1162.0 | |
| Distinct Opioid Count | 2.0 | |
| Opioid Claim Count | 26.0 | |
| Percent Opioid Claims | 2.24 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1124192489 |
| Last Name Of The Provider | BROWN |
| First Name Of The Provider | GORDON |
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