Professor, Medicine, Medical College of Wisconsin

Hematology

Gilbert White is an expert in the field of Hematology. He studied medicine at University of North Carolina at Chapel Hill School of Medicine. University of North Carolina at Chapel Hill School of Medicine is a top medical university. University of North Carolina at Chapel Hill School of Medicine has a rank of 22 in research and a 2 in primary care He received awards:"Elected Member". Gilbert White is also a published doctor. He has 100 publication published. The most recent publication is: Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.

Publications

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• Consensus Review of the Treatment of Cardiovascular Disease in People With Hemophilia A and B.
• Direct Interaction of Kindlin-3 With Integrin αIIbβ3 in Platelets Is Required for Supporting Arterial Thrombosis in Mice.
• B cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia.
• The Partial Thromboplastin Time (PTT).
• Distinct roles for Rap1b in platelet secretion and integrin [alpha]IIb[beta]3 outside-in signaling.
• Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.
• Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
• Hemophilia: an amazing 35-year journey from the depths of HIV to the threshold of cure.
• How we treat a hemophilia A patient with a factor VIII inhibitor.
• Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity.
• A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.
• Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.
• Current status of thrombolytics-the need for better, especially safer, agents.
• Congenital and acquired platelet disorders: current dilemmas and treatment strategies.
• Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia.
• Rap1b is required for normal platelet function and hemostasis in mice.
• The use of recombinant factor VIIa in the treatment of bleeding disorders.
• Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors.
• Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion.
• The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cells.
• Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
• Hepatitis C in adults and adolescents with hemophilia: a randomized, controlled trial of interferon alfa-2b and ribavirin.
• Hemophilia gene therapy: update.
• End-stage liver disease in persons with hemophilia and transfusion-associated infections.
• Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton.
• Cellular immune response to viral peptides in patients exposed to HIV.
• Risk of HIV infection and AIDS in women and girls with coagulation disorders.
• Heparin cofactor activities in a family with hereditary antithrombin III deficiency: evidence for a second heparin cofactor in human plasma.
• Immunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins.
• Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes.
• The effect of phenothiazine and non-phenothiazine inhibitors of calmodulin on platelet calcium fluxes.
• Cirrhosis, variceal bleeding, and distal splenorenal shunt in hemophilia A.
• Colonoscopic polypectomy in Glanzmann's thrombasthenia.
• Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.
• High resolution electrophoretic analysis of human fibrinogen and its crosslinked intermediates.
• Calcium-dependent proteins in platelets: response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agents.
• Factor IX activator content of normal and factor XI deficient serum.
• Glanzmann''s thrombasthenia. Report of two oral surgical cases using a new microfibrillar collagen preparation and EACA for hemostasis.
• Valproic acid: a new antiepileptic drug with potential side effects of dental concern.
• Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.
• Hemophilia, hepatitis, and the acquired immunodeficiency syndrome.
• HTLV-III seroconversion associated with heat-treated factor VIII concentrate.
• Antithrombin-III transfusion in disseminated intravascular coagulation.
• PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
• Procreation and HIV.
• Fatal thrombosis associated with a hemi-fontan procedure, heparin-protamine reversal, and aprotinin.
• Successful treatment of transient acquired factor X deficiency by plasmapheresis with concomitant intravenous immunoglobulin and steroid therapy.
• Evidence that platelet and skeletal sarcoplasmic reticulum Ca2+-ATPase are structurally distinct.
• Tendency to serious sequelae of infection with the human immunodeficiency virus in sibships with hemophilia.
• The hemostatic mechanism: mechanistic, diagnostic and therapeutic considerations.
• Parachutes and prophylaxis: they both work!
• Antenatal cell gene transfer: an immunological Trojan horse?
• Characterization of high-risk HIV-1 seronegative hemophiliacs.
• Platelet physiology and function.
• AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. Hemophilia Malignancy Study Group.
• The genomic organization of platelet glycoprotein IIIa.
• Low incidence of thrombocytopenia with porcine mucosal heparin. A prospective multicenter study.
• Prolonged neonatal alloimmune thrombocytopenic purpura associated with anti-Bak(a). Two cases in siblings.
• Heterogeneity of membrane surface proteins in Glanzmann's thrombasthenia.
• Failure of activated prothrombin complex concentrates in a hemophiliac with an anti-factor VIII antibody.
• Nosocomial infection rate as a function of human immunodeficiency virus type 1 status in hemophiliacs.
• Orthopaedic procedures and prognosis in hemophilic patients who are seropositive for human immunodeficiency virus.
• The effect of platelet inhibitors on glycoprotein V hydrolysis by thrombin.
• Superior mesenteric vein thrombosis with radiologically occult cause: a retrospective study of 43 cases.
• Hydrolysis of human platelet membrane glycoproteins with a Serratia marcescens metalloprotease: effect on response to thrombin and von Willebrand factor.
• Human immunodeficiency virus-1 disease progression in hemophiliacs.
• Platelet factor 4 enhances fibrin fiber polymerization.
• Effect of active site-modified thrombin on the hydrolysis of platelet-associated glycoprotein V by native thrombin.
• Safety and recovery of mononine in multiple-dose, high-dose regimens.
• The effects of trifluoperazine, an inhibitor of calmodulin, on platelet function.
• Wound infection rates after invasive procedures in HIV-1 seropositive versus HIV-1 seronegative hemophiliacs.
• Purified factor IX using monoclonal immunoaffinity technique: clinical trials in hemophilia B and comparison to prothrombin complex concentrates.
• Glycoprotein V hydrolysis by thrombin. Lack of correlation with secretion.
• von Willebrand factor multimeric levels and patterns in patients with severe preeclampsia.
• Identification of T-cell epitopes in clotting factor IX and lack of tolerance in inbred mice.
• Transmission of human immunodeficiency virus to sexual partners of hemophiliacs.
• Medical complications of hemophilia.
• The management of musculoskeletal problems in hemophilia. Part I. Principles of medical management of hemophilia.
• An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin an...
• SH2- and SH3-mediated interactions between focal adhesion kinase and Src.
• Mammalian recombinant coagulation proteins: structure and function.
• Summary of clinical experience with recombinant factor VIII products--Recombinate.
• Kinetic evidence that arachidonate-induced calcium efflux from platelet microsomes involves a carrier-type ionophoric mechanism.
• B-domain deleted recombinant factor VIII preparations are bioequivalent to a monoclonal antibody purified plasma-derived factor VIII concentrate: a randomized, three-w...
• Factor VIII inhibitors: a clinical overview.
• Prediction of inhibitors in hemophilia.
• Prothrombin complex concentrates: potentially thrombogenic materials and clues to the mechanism of thrombosis in vivo.
• Alterations in platelet membrane structure and function during storage at ambient temperature.
• The partial thromboplastin time: defining an era in coagulation.
• Platelet secretion: indiscriminately spewed forth or highly orchestrated?
• The effect of ambient storage on platelet membrane structure and response to thrombin.
• Prothrombin complex concentrates: preparation, properties, and clinical uses.
• ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families.
• The development of a high-order Taylor expansion solution to the chemical rate equation for the simulation of complex biochemical systems.
• Thrombin binding to thrombasthenic platelets.
• Incidence of lymphomas and other cancers in HIV-infected and HIV-uninfected patients with hemophilia.
• Structure-function relations in platelet-thrombin reactions. Inhibition of platelet-thrombin interactions by lysine modification.
• Clinical experience of a new monoclonal antibody purified factor IX: half-life, recovery, and safety in patients with hemophilia B.
• Recombinant factor IX.

Schools

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• University of North Carolina At Chapel Hill

Doctors Specialties

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• Internal Medicine
• Hematology

Accepted Insurances

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Awards

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• Elected Member

Education

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• University of North Carolina Hospitals
• Georgetown University Hospital
• University of North Carolina at Chapel Hill School of Medicine

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