Professor, Neurology, Perelman School of Medicine
Neurology
Dr. Gihan I. Tennekoon, MD
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Gihan I. Tennekoon, MD works in the field of Neurology. He received awards:"Super Doctor". Dr. Gihan I. Tennekoon is a published doctor and has 72 publications published. The lastest was: 'Schwann cell-conditioned medium promotes neuroblastoma survival and differentiation.'
Publications
- Physical therapy services received by individuals with spinal Muscular atrophy (SMA).
- Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne Muscular dystrophy cohort.
- Spectrum of neuropathophysiology in spinal Muscular atrophy type I.
- Sildenafil does not improve cardiomyopathy in Duchenne/Becker Muscular dystrophy.
- Severe congenital RYR1-associated myopathy: the expanding clinicopathologic and genetic spectrum.
- Juvenile-onset motor neuron disease caused by novel mutations in ?-hexosaminidase.
- Umbilical cord blood transplantation for juvenile metachromatic leukoDystrophy.
- Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations.
- Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells.
- Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with duchenne Muscular dystrophy: a multicenter cross sectional study.
- Kinetics of insulin receptor transit to and removal from the plasma membrane.
- Spin-label studies of erythrocytes in myotonic Dystrophy: no increase in membrane fluidity.
- Advances in understanding the development of the nervous system.
- Hemosiderin-laden macrophages in the cerebroSpinal fluid of a neonate after traumatic lumbar puncture.
- Conus medulla-cauda compression from Nerve root hypertrophy in a child with Dejerine-Sottas syndrome: improvement with laminectomy and duraplasty. Case report.
- Myelin and Disorders that affect the formation and maintenance of this sheath.
- Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance.
- Anti-galactocerebroside antibodies in human cerebroSpinal fluids determined by enzyme-linked immunosorbent assay (ELISA).
- Purification and characterization of galactocerebroside sulfotransferase from rat kidney.
- Fetal metachromatic leukoDystrophy: pathology, biochemistry and a study of in vitro enzyme replacement in CNS tissue.
- Chronic lead inToxication: effects on developing optic nerve.
- Galactocerebroside sulfotransferase: further characterization of the enzyme from rat brain.
- Sulfatide synthesis in mice with defective synthesis of 3''-phosphoadenosine 5''-phosphosulfate.
- Childhood Multiple sclerosis: a review.
- Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected Nerves and cultured Schwann cells.
- Regulation of glucose transport in cultured Schwann cells.
- Topography of cerebroside sulfotransferase in Golgi-enriched vesicles from rat brain.
- Inhibition of rat brain galactocerebroside sulfotransferase by triazine aromatic dyes: interaction with the 3'-phosphoadenosine 5'-phosphosulfate binding site.
- Increased P0 glycoprotein gene expression in primary and transfected rat Schwann cells after treatment with axolemma-enriched fraction.
- Establishment of cell lines from primary cultures by transfection with SV40 large T antigen gene.
- Characterization of a cloned cDNA encoding rabbit myelin P2 protein.
- Partial structure and mapping of the human myelin P2 protein gene.
- Spatial segregation of mRNA encoding myelin-specific proteins.
- Notch and Schwann cell transformation.
- Purification and expansion of human Schwann cells in vitro.
- The simian virus 40 large T antigen does not inhibit translation of the 14-kDa myelin basic protein mRNA in reticulocyte lysates or in transfected cells.
- Cerebroside sulfotransferase: preparation of antibody and localization of antigen in kidney.
- SV40 large T antigen with c-Jun down-regulates myelin P0 gene expression: a mechanism for papovaviral T antigen-mediated demyelination.
- Characterization of the cis-acting elements of the mouse myelin P2 promoter.
- Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation.
- The differentiation of oligodendrocytes in the rat Optic nerve.
- Reconstitution of adenosine 3'-phosphate 5'-phosphosulfate transporter from rat brain.
- Selective growth of rat Schwann cells in neuron- and serum-free primary culture.
- Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.
- Choline acetyltransferase activity in striatum of neonatal rats increased by Nerve growth factor.
- Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter.
- Isolation of rat Schwann cell lines: use of SV40 T antigen gene regulated by synthetic metallothionein promoters.
- Myelinogenesis in Optic nerve. A morphological, autoradiographic, and biochemical analysis.
- Immunoreactive myelin basic protein in cerebrospinal fluid of patients with Peripheral neuropathies.
- Production of Schwann cell lines using a regulated oncogene.
- Proliferation and differentiation of a transfected Schwann cell line is altered by an artificial basement membrane.
- The role of complex carbohydrates in adhesion of the myelin protein, P0.
- Structure of the mouse myelin P2 protein gene.
- High level of expression of the myelin protein P0 in Chinese hamster ovary cells.
- Evidence that secondary rat Schwann cells in culture maintain their differentiated phenotype.
- Role of myelin P0 protein as a homophilic adhesion molecule.
- Selective culture of mitotically active human Schwann cells from adult sural Nerves.
- Myelin P0-protein, more than just a structural protein?
- Reciprocal Id expression and myelin gene regulation in Schwann cells.
- Progressive spinal Muscular atrophies.
- Signals for proInflammatory cytokine secretion by human Schwann cells.
- Schwann cell-conditioned medium promotes neuroblastoma survival and differentiation.
- A role for Pak protein kinases in Schwann cell transformation.
- The zinc finger transcription factor Zif268/Egr-1 is Essential for Schwann cell expression of the p75 NGF receptor.
- Sources of human Schwann cells and the influence of donor age.
- Homophilic adhesion of the myelin P0 protein requires glycosylation of both molecules in the homophilic pair.
- Neurofibromatosis type 1: II. Answers from animal models.
- Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival.
- Neurofibromatosis type 1. I. General overview.
- Mega-corpus callosum, polymicrogyria, and psychomotor retardation: confirmation of a syndromic entity.
- Pediatric optic neuritis: brain MRI abnormalities and risk of Multiple sclerosis.
Schools
University Of London Faculty Of Medicine Charing Cross Hospital
Queen Marys Hospital
Chldns Hospital Med Center
Johns Hopkins
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Ataxia
- Autonomic Disorders
- Bell's Palsy
- Convulsions
- View All
Doctors Specialties
- Neurology
Accepted Insurances
Awards
- Super Doctor
Education
-
Johns Hopkins University -
Boston Children's Hospital
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