Physician
Medical Genetics
Dr. Gerald T. Nepom, MD
Gerald T. Nepom, MD is an expert in the field of Medical Genetics. He researched medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Doctor Gerald T. Nepom, MD is a published doctor. He published 67 publications, including: 'Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.'
Publications
- Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.
- Restoring the balance: immunotherapeutic combinations for autoimmune disease.
- Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.
- Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice.
- Anti-cytokine therapies in T1D: Concepts and strategies.
- A functional framework for interpretation of genetic associations in T1D.
- MHC class II tetramers.
- Hyaluronan and versican in the control of human T lymphocyte adhesion and migration.
- Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis.
- ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.
- Erratum: Common variants in P2RY11 are associated with narcolepsy.
- Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction.
- Common variants in P2RY11 are associated with narcolepsy.
- A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.
- Prediction and pathogenesis in type 1 diabetes.
- Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreact...
- On-chip activation and subsequent detection of individual antigen-specific T cells.
- Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.
- Changes in autoreactive T cell avidity during type 1 diabetes development.
- CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.
- Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms.
- Narcolepsy is strongly associated with the T-cell receptor alpha locus.
- Animal models of human type 1 diabetes.
- The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.
- Approaching the Heisenberg principle of immunology.
- Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen.
- A nexus of science and clinical immunology: the Federation of Clinical Immunology Societies and the FOCIS Centers of Excellence.
- Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer.
- Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive ...
- Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells.
- Autoreactive T cells in a partially humanized murine model of T1D.
- Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice.
- Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.
- Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives.
- Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.
- Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.
- DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
- Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.
- Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.
- The insulin A-chain epitope recognized by human T cells is posttranslationally modified.
- Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity.
- Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
- Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
- De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.
- Tetramer analysis of human autoreactive CD4-positive T cells.
- Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort.
- Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.
- GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
- Extensive replicative capacity of human central memory T cells.
- Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.
- MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.
- Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.
- Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity.
- Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme ...
- MHC multimers: expanding the clinical toolkit.
- HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells.
- Defining antigen-specific responses with human MHC class II tetramers.
- Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
- Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?
- Class II peptide multimers: promise for type 1A diabetes?
- Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones.
- Transcript array analysis in rheumatology.
- HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.
- Avidity-Dependent Programming of Autoreactive T Cells in T1D.
- Reversal of diabetes in mice with a bioengineered islet implant incorporating a type I collagen hydrogel and sustained release of vascular endothelial growth factor.
- IL-10 induction from implants delivering pancreatic islets and hyaluronan.
Schools
University of Washington
Caritas Carney Hospital
Harvard Med School
Doctors Specialties
- Immunology
- Medical Genetics
Accepted Insurances
Education
-
Harvard Medical School -
University of Washington School of Medicine
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