Adjunct Professor, Biological Sciences, Carnegie Mellon University Previous - Professor, Psychiatry, University of Pittsburgh School of Medicine
Psychiatry
Dr. George S. Zubenko, MD
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George S. Zubenko works in the field of Psychiatry. He researched medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received awards:"Fellow", "Distinguished Fellow", "Independent Scientist Award", "M.D., Cum Laude", "Elected Member" and "Mirsky Memorial Award". Doctor George S. Zubenko, MD has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Age at onset in geriatric bipolar disorder. Effects on clinical presentation and treatment outcomes in an inpatient sample.'
Publications
- Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive Disorder.
- Alterations of brain anatomy in mouse model of MDD created by replacement of homologous mouse DNA sequence with an illness-associated 6-base human CREB1 promoter seque...
- No evidence of non-homologous insertions in mouse model of MDD created by replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequ...
- Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive Disorder.
- Effects of the A(-115)G variant on CREB1 promoter activity in two brain cell lines: Interactions with gonadal steroids.
- D10S1423 identifies a susceptibility locus for Alzheimer's Disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: results at 14 ...
- Genetic linkage of region containing the CREB1 gene to depressive Disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation o...
- Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7.
- Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental Disorder...
- Effects of the G(-656)A variant on CREB1 promoter activity in a glial cell line: interactions with gonadal steroids and stress.
- Elderly patients with Dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy.
- Reduced age-related cataracts among elderly persons who reach age 90 with preserved cognition: a biomarker of successful aging?
- Genome survey for loci that influence successful aging: results at 10-cM resolution.
- Genetics of recurrent early-onset major Depression (GenRED): final genome scan report.
- Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in Dementia.
- Effects of previous major depressive illness on cognition in Alzheimer Disease patients.
- Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major Depression.
- Genomewide significant linkage to recurrent, early-onset major depressive Disorder on chromosome 15q.
- Genome-wide linkage survey for genetic loci that influence the development of depressive Disorders in families with recurrent, early-onset, major depression.
- Genetics of recurrent early-onset Depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies.
- A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's Disease.
- Genetic linkage of region containing the CREB1 gene to depressive Disorders in women from families with recurrent, early-onset, major depression.
- Genetic segregation analysis of alcohol and other substance-use Disorders in families with recurrent, early-onset major depression.
- Genome survey for loci that influence successful aging: sample characterization, method validation, and initial results for the Y chromosome.
- Genome survey for susceptibility loci for recurrent, early-onset major Depression: results at 10cM resolution.
- Genetic segregation analysis of recurrent, early-onset major Depression: evidence for single major locus transmission.
- Management of a case of neuroleptic malignant syndrome with bromocriptine.
- A genome survey for novel Alzheimer Disease risk loci: results at 10-cM resolution.
- Initial results of a genome survey for novel Alzheimer's Disease risk genes: association with a locus on the X chromosome.
- Is delirium different when it occurs in Dementia? A study using the delirium rating scale.
- Determinants of spontaneous extrapyramidal symptoms in elderly psychiatric inpatients diagnosed with Alzheimer's disease, major depressive Disorder, or psychotic disor...
- Agitation in Dementia.
- Molecular neurobiology of Alzheimer's Disease (syndrome?).
- Genetic segregation analysis of early-onset recurrent unipolar Depression.
- Mortality of elderly patients with psychiatric Disorders.
- Clinicopathologic and neurochemical correlates of major depression and psychosis in primary Dementia.
- Medical comorbidity in elderly psychiatric inpatients.
- Association of the APOE epsilon 4 allele with clinical subtypes of late life Depression.
- MRI changes in schizophrenia in late life: a preliminary controlled study.
- Prospective study of increased platelet membrane fluidity as a risk factor for Alzheimer's Disease: results at 5 years.
- Reliability and applicability of movement Disorder rating scales in the elderly.
- Platelet membrane fluidity.
- Schizophrenia in late life: elderly patients admitted to an acute care psychiatric hospital.
- Lack of variation in the nucleotide sequence corresponding to the transmembrane domain of the beta-amyloid precursor protein in Alzheimer's Disease.
- The Delirium Rating Scale in a psychogeriatric inpatient setting.
- Diagnostic rate of comorbid personality Disorder in elderly psychiatric inpatients.
- Ethnicity and psychopathology in an aging hospital-based population. A comparison of African-American and Anglo-European patients.
- Impact of acute psychiatric inpatient treatment on major Depression in late life and prediction of response.
- Association of the apolipoprotein E epsilon 4 allele with clinical subtypes of autopsy-confirmed Alzheimer's Disease.
- Complicated grief and bereavement-related depression as distinct Disorders: preliminary empirical validation in elderly bereaved spouses.
- Duration of neuroleptic treatment and prevalence of tardive dyskinesia in late life.
- Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiae.
- Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae.
- Mapping of the proteinase b structural gene PRB1, in Saccharomyces cerevisiae and identification of nonsense alleles within the locus.
- Proteolytic inactivation of the NADP-dependent glutamate dehydrogenase in proteinase-deficient mutants of Saccharomyces cerevisiae.
- Genetic properties of mutations at the PEP4 locus in Saccharomyces cerevisiae.
- PEP4 gene function is required for expression of several vacuolar hydrolases in Saccharomyces cerevisiae.
- Disturbances of thirst and water homeostasis in patients with affective illness.
- Lack of functional messenger RNA (mRNA) coding for a microtubule-associated protein correlates with poor performance of rats in a behavioral paradigm.
- Sequence variations in CREB1 cosegregate with depressive Disorders in women.
- D2S2944 identifies a likely susceptibility locus for recurrent, early-onset, major Depression in women.
- A naturalistic study of trazodone in the treatment of behavioral complications of Dementia.
- A user-friendly instrument for rating agitation in Dementia patients.
- Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress.
- Malignancy of recurrent, early-onset major Depression: a family study.
- A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic Depression in late life.
- D10S1423 identifies a susceptibility locus for Alzheimer''s Disease in a prospective, longitudinal, double-blind study of asymptomatic individuals.
- Do susceptibility loci contribute to the expression of more than one mental Disorder? A view from the genetics of Alzheimer''s disease.
- Geriatric psychopharmacology: why does age matter?
- Rapid and opposite effects of cortisol and estradiol on human erythrocyte Na+,K+-ATPase activity: relationship to steroid intercalation into the cell membrane.
- Clinical and neurobiological correlates of D10S1423 genotype in Alzheimer's Disease.
- Platelet membrane fluidity individuals at risk for Alzheimer''s Disease: a comparison of results from fluorescence spectroscopy and electron spin resonance spectroscopy.
- Clinical and neurobiological correlates of DXS1047 genotype in Alzheimer's Disease.
- Reductions in brain phosphatidylinositol kinase activities in Alzheimer's Disease.
- Neurobiological correlates of a putative risk allele for Alzheimer's Disease on chromosome 12q.
- Age at onset in geriatric bipolar Disorder. Effects on clinical presentation and treatment outcomes in an inpatient sample.
- Prospective study of risk factors for Alzheimer's Disease: results at 7.5 years.
- Linkage and association analysis of chromosomal regions containing genes related to neuroendocrine or serotonin function in families with early-onset, recurrent major ...
- An open-label pilot study of oral S-adenosylmethionine in major Depression. An interim report.
- Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's Disease and Parkins...
- Captopril and teprotide as discriminators of angiotensin-converting enzyme activity in brain tissue.
- Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer''s Disease, Parkinson''s Disease and progressive supranuclear palsy.
- Markedly increased platelet membrane fluidity in Down syndrome with a (14q, 21q) translocation.
- SOD-1 activity and platelet membrane fluidity in Alzheimer's Disease.
- Adrenoceptors and the pharmacology of affective illness: a unifying theory.
- A cell membrane correlate of tardive dyskinesia in patients treated with phenothiazines.
- Effects of psychotropic agents on the physical properties of platelet membranes in vitro.
- In vivo effects of psychotropic agents on the physical properties of cell membranes in the rat brain.
- Effects of phenothiazine treatment on the physical properties of platelet membranes from psychiatric patients.
- Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus.
- Endoplasmic reticulum abnormality in Alzheimer's Disease: selective alteration in platelet NADH-cytochrome c reductase activity.
- Lateralization of brain morphologic and cholinergic abnormalities in Alzheimer's Disease.
- A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's Disease.
- Inheritance pattern of platelet membrane fluidity in Alzheimer Disease.
- Brain regional analysis of NADH-cytochrome C reductase activity in Alzheimer's Disease.
- Progression of illness in the differential diagnosis of primary Dementia.
- Brain imaging abnormalities in mental Disorders of late life.
- Risk factors for white matter changes detected by magnetic resonance imaging in the elderly.
- Shy-Drager syndrome presenting as a REM behavioral Disorder.
Schools
University of Pittsburgh School of Medicine
Mt AuburnHarvard
McLeanHarvard Med Sch
Carnegie Mellon U
Conditions Treated
- Adjustment Disorder
- Alzheimer's Disease
- Anxiety
- Attention Deficit Disorder (ADD)
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Doctors Specialties
- Geriatric Psychiatry
- Psychiatry
Accepted Insurances
Awards
- Fellow
- Distinguished Fellow
- Independent Scientist Award
- M.D., Cum Laude
- Elected Member
- Mirsky Memorial Award
Education
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Harvard Medical School -
University of Pittsburgh School of Medicine
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