Physician

Family Medicine

George H. Chaconas, MD works in the field of Family Medicine. He went to Eastern Virginia Medical School. He received awards:"CMS Meaningful Use Stage 1 Certification". George Chaconas is a published doctor. He has 48 papers published. The most current publication "Mutations in domain III alpha of the Mu transposase: evidence suggesting an active site component which interacts with the Mu-host junction." He accepts Medicare.

Publications

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• The circle is broken: telomere resolution in linear replicons.
• Effect of mutations in the Mu-host junction region on transpososome assembly.
• Telomere resolution in the Lyme disease spirochete.
• The solution structure of the C-terminal domain of the Mu B transposition protein.
• Site-specific DNA binding and bending by the Borrelia burgdorferi Hbb protein.
• Studies on a "jumping gene machine": Higher-order nucleoprotein complexes in Mu DNA transposition.
• Supercoiling-dependent site-specific binding of HU to naked Mu DNA.
• Mutations in domain III alpha of the Mu transposase: evidence suggesting an active site component which interacts with the Mu-host junction.
• Disruption of target DNA binding in Mu DNA transposition by alteration of position 99 in the Mu B protein.
• A new set of Mu DNA transposition intermediates: alternate pathways of target capture preceding strand transfer.
• The Mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of Mu A promotes the reaction in the absence of Mu B.
• DNA transposition: jumping gene machine, some assembly required.
• Anatomy of a flexer-DNA complex inside a Higher-order transposition intermediate.
• Three-site synapsis during Mu DNA transposition: a critical intermediate preceding engagement of the active site.
• Transposition of phage Mu DNA.
• Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease.
• A second High affinity HU binding site in the phage Mu transpososome.
• Characterization of a region in phage Mu transposase that is involved in interaction with the Mu B protein.
• A novel DNA binding and nuclease activity in domain III of Mu transposase: evidence for a catalytic region involved in donor cleavage.
• Studies on the heterogeneity of the 5'' ends of the protamine mRNAs from rainbow trout testis.
• Predominant integration end products of infecting bacteriophage Mu DNA are simple insertions with no preference for integration of either Mu DNA strand.
• Predominant end-products of prophage Mu DNA transposition during the lytic cycle are replicon fusions.
• Mechanism of bacteriophage Mu DNA transposition.
• In vitro and in vivo manipulations of bacteriophage Mu DNA: cloning of Mu ends and construction of mini-Mu''s carrying selectable markers.
• Association of Mu-containing plasmids with the Escherichia coli chromosome upon prophage induction.
• 5'-32P labeling of RNA and DNA restriction fragments.
• Transposition of bacteriophage mu DNA: expression of the A and B proteins from lambda pL and analysis of infecting mu DNA.
• The nucleotide sequence of the B gene of bacteriophage Mu.
• Transpososomes: stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA.
• Electron microscopic analysis of in vitro transposition intermediates of bacteriophage Mu DNA.
• The bacteriophage Mu N gene encodes the 64-kDa virion protein which is injected with, and circularizes, infecting Mu DNA.
• Primary structure of phage mu transposase: homology to mu repressor.
• A truncated form of the bacteriophage Mu B protein promotes conservative integration, but not replicative transposition, of Mu DNA.
• Amplification and purification of the bacteriophage Mu encoded B transposition protein.
• Sequence of bacteriophage Mu N and P genes.
• Mechanism of Mu DNA transposition.
• A protein factor which reduces the negative supercoiling requirement in the Mu DNA strand transfer reaction is Escherichia coli integration host factor.
• Secondary structural features of the bacteriophage Mu-encoded A and B transposition proteins.
• Action at a distance in Mu DNA transposition: an enhancer-like element is the site of action of supercoiling relief activity by integration host factor (IHF).
• Immunoelectron microscopic analysis of the A, B, and HU protein content of bacteriophage Mu transpososomes.
• Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein, and the requirement of DNA nicking for stable type 1 transpososome formation. In...
• Structural aspects of a Higher order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu type 1 transpososome.
• Stimulation of the Mu DNA strand cleavage and intramolecular strand transfer reactions by the Mu B protein is independent of stable binding of the Mu B protein to DNA.
• Mechanistic aspects of DNA transposition.
• Role of the A protein-binding sites in the in vitro transposition of mu DNA. A complex circuit of interactions involving the mu ends and the transpositional enhancer.
• Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro mu DNA strand transfer reaction.
• The Mu transpositional enhancer can function in trans: requirement of the enhancer for synapsis but not strand cleavage.

Schools

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• Eastern Virginia Medical School Of The Medical College Of Hampton Roads

• Roanoke Meml Hospital

• Virginia Tech

• Diplomate American Board Of Clinical Lipidology

Conditions Treated

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• High Cholesterol
• Hyperlipidemia

Doctors Specialties

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• Clinical Lipidology
• Family Medicine

Accepted Insurances

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• Choice Plus POS II
• HealthKeepers HMO
• KeyCare PPO
• Assurant Health
• Blue Card PPO
• CHAMPVA
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• Open Access
• Commercial Insurance Company
• CoreSource
• Coventry Health Care
• First Health (Coventry Health Care) PPO
• Golden Rule
• GEHA
• Tricare
• HealthSmart
• Choice Care PPO
• Medicare MCR
• MultiPlan PPO
• POMCO Group
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• Universal American

Awards

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• CMS Meaningful Use Stage 1 Certification

Education

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• Eastern Virginia Medical School

Drug Facts

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NPI NUMBER		1720069354
NPPES Provider LastName		CHACONAS
NPPES Provider FirstName		GEORGE
NPPES Provider ZIPCode		241844128
NPPES Provider State		VA
Specialty Description		Family Practice
Total Claim Count		11951.0
Distinct Opioid Count		4.0
Opioid Claim Count		496.0
Percent Opioid Claims		4.15

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1720069354
Last Name Of The Provider	CHACONAS
First Name Of The Provider	GEORGE
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