Professor of Pediatrics, UCSD
Pediatrics
Dr. Gabriel G. Haddad, MD
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Gabriel Haddad works in the field of Pediatrics. He has 3 awards "Top Doctors:San Diego Area", "Top Doctors:Southern California" and "Top Doctors: New York Metro Area". Gabriel Haddad is also published. He has 99 publications published. The lastest publication: "Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation.'
Publications
- Shared genetic signals of hypoxia adaptation in Drosophila and in high-altitude human populations.
- Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease.
- Notch Activation of Ca(2+) Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.
- A Drosophila ABC Transporter Regulates Lifespan.
- The Genetic Basis of Chronic Mountain Sickness.
- Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.
- Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2.
- Do BK channels mediate glioma hypoxia-tolerance?
- Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma.
- Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.
- Intermittent Hypoxia and Hypercapnia induce Pulmonary Artery Atherosclerosis and Ventricular Dysfunction in Low Density Lipoprotein Receptor Deficient Mice.
- Whole-Genome Sequencing Uncovers the Genetic Basis of Chronic Mountain Sickness in Andean Highlanders.
- Genetic Analysis of Hypoxia Tolerance and Susceptibility in Drosophila and Humans.
- Chemokine receptor-like 2 is involved in ischemic brain injury.
- Genetic Animal Models Of Preconditioning.
- DIDS Prevents Ischemic Membrane Degradation in Cultured Hippocampal Neurons by Inhibiting Matrix Metalloproteinase Release.
- Role of high-fat diet in stress response of Drosophila.
- Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.
- An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons.
- Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production?
- Hypoxia induces K(v) channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
- Identification of a neuronal gene expression signature: Role of cell-cycle arrest in murine neuronal differentiation in vitro.
- Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia.
- Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster.
- Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster.
- Experimental selection of hypoxia-tolerant Drosophila melanogaster.
- Does the brain gain back energy during sleep? But what does it mean?
- Hematopoietic stem cell transplantation protects mice from lethal stroke.
- Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.
- Chronic hypercapnia alters lung matrix composition in mouse pups.
- Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.
- The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.
- Heart rhythm genomic fabric in hypoxia.
- Experimental selection for Drosophila survival in extremely high O2 environments.
- Survival in acute and severe low o environment: use of a genetic model system.
- Introduction to hypoxia and consequences: from molecule to malady.
- Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia.
- Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.
- Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster.
- Can O2 dysregulation induce premature aging?
- Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch.
- Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.
- Role of transporters and ion channels in neuronal injury under hypoxia.
- Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development.
- TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.
- Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.
- Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
- Hypoxia increases BK channel activity in the inner mitochondrial membrane.
- Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2.
- Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia.
- Chronic intermittent but not constant hypoxia decreases NAA/Cr ratios in neonatal mouse hippocampus and thalamus.
- Chronic high-inspired CO2 decreases excitability of mouse hippocampal neurons.
- Experimental selection for Drosophila survival in extremely low O(2) environment.
- Effect of carbon dioxide on neonatal mouse lung: a genomic approach.
- Transcriptomic changes in developing kidney exposed to chronic hypoxia.
- Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination.
- Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia.
- Identification of new targets of Drosophila pre-mRNA adenosine deaminase.
- Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia?
- Effect of chronically elevated CO2 on CA1 neuronal excitability.
- Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain.
- A critical role of neural-specific JNK3 for ischemic apoptosis.
- Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance.
- Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions.
- Maturation of neuronal excitability in hippocampal neurons of mice chronically exposed to cyclic hypoxia.
- Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons.
- Na+ channel expression and neuronal function in the Na+/H+ exchanger 1 null mutant mouse.
- Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia.
- Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster.
- Slot-blot hybridization in studying gene expression during oxygen deprivation.
- Hematopoietic stem cells: potential new applications for translational medicine.
- MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data.
- Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures.
- Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.
- DIDS (4,4-Diisothiocyanatostilbenedisulphonic Acid) Induces Apoptotic Cell Death in a Hippocampal Neuronal Cell Line and Is Not Neuroprotective against Ischemic Stress.
- Sensitive immunofluorescence detection of the expression of P-glycoprotein in malignant cells.
- Fracture of bone materials in compression at temperatures between -200 degree C and +200 degree C.
- The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells.
- Mediterranean Sea surface radiocarbon reservoir age changes since the last glacial maximum.
- A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.
- Effect of endorphins on heart rate and blood pressure in adult dogs.
- P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy.
- Decreased follistatin gene expression in gonadotroph adenomas.
- Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation.
- Effect of external factors on gonadal activity and body mass of male golden hamsters (Mesocricetus auratus).
- Modulation of renal glomerular angiotensin II receptors by ace inhibition and AT1 receptor antagonism.
- Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas.
- Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression.
- Effect of parasympathetic blockade on ventilatory and cardiac depression induced by opioids.
- Cardiorespiratory control in sudden infant death syndrome.
- The role of airway receptors in the control of respiration in infants: a review.
- Modulation of Ca2+ and Na+ transport by taurine in heart and vascular smooth muscle.
- Respiratory waveform pattern recognition using digital techniques.
- The effect of prolonged oligohydramnios on fetal lung development, maturation and ventilatory patterns in the newborn guinea pig.
- Ventilation and ventilatory pattern during sleep in aborted sudden infant death syndrome.
- Determination of sleep state in infants using respiratory variability.
- Relation of beat-to-beat variability to heart rate in normal sleeping infants.
- Abnormal maturation of sleep states in infants with aborted sudden infant death syndrome.
Schools
American University of Beirut Faculty of Medicine
Am University Beirut Med Center
University Tex Med Center
Columbia University PampS
Doctors Specialties
- Pediatrics
Accepted Insurances
Awards
- Top Doctors:San Diego Area
- Top Doctors:Southern California
- Top Doctors: New York Metro Area
Education
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New York Presbyterian Hospital - Columbia Campus -
American University of Beirut Faculty of Medicine
Hospital
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Rady Children's Hospital - San Diego
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