Samuel E. Schechter Professor, Internal Medicine, Washington University in St. Louis School of Medicine
Internal Medicine
Dr. Fumihiko Urano, MD
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Fumihiko Urano works in the field of Internal Medicine. He studied medicine at Keio Gujuku University School of Medicine. He over the years received 1 awards: "Elected Member". Fumihiko Urano has written publications. He has 22 publications published with PubMed. The lastest publication is: 'Maternal uniparental disomy of chromosome4 and homozygous novel mutation in the WFS1 gene in a paediatric patient with Wolfram syndrome.'
Publications
- Maternal uniparental disomy of chromosome 4 and homozygous novel mutation in the WFS1 gene in a paediatric patient with Wolfram syndrome.
- Research Resource: Monitoring Endoplasmic Reticulum Membrane Integrity in β-Cells at the Single-Cell Level.
- A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.
- Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
- Calcium efflux from the endoplasmic reticulum leads to beta-cell death.
- Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease.
- Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.
- Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rgamma(null) mice treated with alogliptin.
- Endoplasmic reticulum: an interface between the immune system and metabolism.
- Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.
- Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.
- KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
- Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation.
- FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress.
- The IRE1alpha-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis.
- c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.
- Thioredoxin-interacting protein mediates ER stress-induced beta cell death through initiation of the inflammasome.
- Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement.
- Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.
- ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes.
- Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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Keio Gujuku University School of Medicine
Hospital
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Barnes-Jewish Hospital
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