Physician
Pathology
Dr. Frederic G. Barr, MD
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Frederic Barr works in the field of Pathology. He went to Washington University School of Medicine in St. Louis. He has 1 awards "Elected Member". Frederic Barr is a published MD. He has 53 papers published. The most current publication "Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications."
Publications
- CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma.
- Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications.
- Distinct methylation profiles characterize fusion-positive and fusion-negative rhabdomyosarcoma.
- Clonality and evolutionary history of rhabdomyosarcoma.
- Malignant round cell tumor of bone with EWSR1-NFATC2 gene fusion.
- A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
- Myogenin, AP2β, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology...
- Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
- The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.
- Classification of rhabdomyosarcoma and its molecular basis.
- A novel algorithm for simplification of complex gene classifiers in cancer.
- Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's...
- PAX-FOXO1 Fusion Status Drives Unfavorable Outcome for Children With Rhabdomyosarcoma: A Children's Oncology Group Report.
- A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.
- New Treatments for Rhabdomyosarcoma: The Importance of Target Practice.
- Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signalin...
- Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group.
- Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
- Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.
- Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas.
- Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature.
- Role of fusion subtype in Ewing sarcoma.
- Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas.
- High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts.
- Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
- ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status.
- Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
- Embryonal and alveolar rhabdomyosarcoma of parameningeal sites in adults: a report of 13 cases.
- Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target.
- Molecular diagnosis of ewing family tumors: too many fusions... ?
- Analysis of genetic events that modulate the oncogenic and growth suppressive activities of the PAX3-FKHR fusion oncoprotein.
- Desmoplastic small round cell tumor of the kidney in childhood.
- The impact of genetics on sarcoma diagnosis: an evolving science.
- Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma.
- Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: a report from the Childr...
- Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology Group.
- Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.
- Looking downstream of sarcoma-associated chimeric transcription factors: when is a target really a target?
- PDGF-A, PDGF-Rbeta, TGFbeta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmopla...
- Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.
- Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product.
- Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation.
- CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.
- Unique patterns of allelic imbalance distinguish type 1 from type 2 sporadic papillary renal cell carcinoma.
- Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions.
- Chromosomal translocations and sarcomas.
- PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
- Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar...
- Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
- Molecular pathogenesis of rhabdomyosarcoma.
- Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis.
- Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.
Schools
Washington Center School of Medicine
University Of Pa Health System
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
- Blue Card PPO
- Community Blue PPO
- QualCare HMO
- QualCare PPO
Awards
- Elected Member
Education
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University of Pennsylvania Health System -
Washington University School of Medicine in St. Louis
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