Physician
Pediatric Gastroenterology
Dr. Fayez K. Ghishan, MD
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Dr. Fayez K. Ghishan is an expert in the field of Pediatric Gastroenterology. He over the years received 1 awards: "Fellow (FAAP)". Fayez K. Ghishan is a published MD as well. He has 101 publications published. The latest was: Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion disease.
Publications
- Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice.
- Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNFα regulation.
- Loss of NHE8 expression impairs intestinal mucosal integrity.
- EXPERIMENTAL Colitis IS ASSOCIATED WITH TRANSCRIPTIONAL INHIBITION OF Na+/Ca2+ EXCHANGER ISOFORM 1 (NCX1) EXPRESSION BY INTERFERON GAMMA IN THE RENAL DISTAL CONVOLUTED...
- Disruption of NHE8 Expression Impairs Leydig cell function in the testes.
- Loss of NHE8 expression impairs ocular surface function in mice.
- Clinical Characteristics Associated With Postoperative Intestinal Epithelial Barrier Dysfunction in Children With Congenital Heart Disease.
- Epithelial Transport in Inflammatory Bowel Diseases.
- pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1).
- Reduced colonic microbial diversity is associated with Colitis in NHE3-deficient mice.
- Post-Translational Loss of Renal TRPV5 Calcium Channel Expression, Ca(2+) Wasting, and Bone Loss in Experimental Colitis.
- High vitamin D3 diet administered during active Colitis negatively affects bone metabolism in an adoptive T cell transfer model.
- NHE8 plays an important role in mucosal protection Via its effect on bacterial adhesion.
- NHE8 plays important roles in Gastric mucosal protection.
- T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome.
- Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen.
- The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors.
- Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb.
- Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes.
- Transcriptional regulation of the rat NHE3 gene. Functional interactions between GATA-5 and Sp family transcription factors.
- Characterization of vesicular glutamate transporter in pancreatic alpha - and beta -cells and its regulation by glucose.
- Research agenda for pediatric gastroenterology, hepatology and nutrition: developmental physiology and pathophysiology. Report of the North American Society for Pediat...
- Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny.
- Glucocorticoid regulation of the murine PHEX gene.
- Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3).
- The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine Colitis.
- Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells.
- Regulation of cholesterol homeostasis in solid organ transplantation.
- Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells.
- Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains.
- 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-Gastrointestinal-skeletal axis that controls phosphate transport.
- Molecular physiology of vesicular glutamate transporters in the digestive system.
- Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8.
- Identification of differentially expressed genes in Response to dietary iron deprivation in rat duodenum.
- Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex.
- Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter.
- Effects of Boswellia serrata in mouse models of chemically induced Colitis.
- NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene.
- 1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the...
- Genetic Responses to dietary phosphorus deprivation: lessons learned from the rainbow trout.
- Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2.
- Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal Colitis.
- Sp1 is required for glucose-induced transcriptional regulation of mouse vesicular glutamate transporter 2 gene.
- Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8).
- Protective effects of dietary curcumin in mouse model of chemically induced Colitis are strain dependent.
- Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells.
- Molecular mechanism of rat NHE3 gene promoter regulation by sodium butyrate.
- 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation ...
- Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen...
- Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.
- Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with Colitis.
- Ion transport in the intestine.
- Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury.
- Tumor necrosis factor-alpha impairs intestinal phosphate absorption in Colitis.
- Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
- Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation.
- Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis.
- NHE2X3 DKO mice exhibit gender-specific NHE8 compensation.
- Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway.
- Advances in the understanding of mineral and bone metabolism in inflammatory bowel Diseases.
- Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts.
- Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.
- Small intestinal ion transport.
- Curcumin inhibits interferon-? signaling in colonic epithelial cells.
- From probiotics to therapeutics: another step forward?
- NHE3 modulates the severity of Colitis in IL-10-deficient mice.
- Modulation of neutrophil motility by curcumin: implications for inflammatory bowel Disease.
- Limited effects of dietary curcumin on Th-1 driven Colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection.
- Nonalcoholic fatty liver Disease in children: a single center experience.
- Apical NA+/H+ exchangers in the mammalian Gastrointestinal tract.
- Persistent and chronic diarrhea and malabsorption: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition.
- Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter.
- Regulation of the rat NHE3 gene promoter by sodium butyrate.
- Epidermal growth factor regulation of rat NHE2 gene expression.
- Molecular and functional analysis of a novel neuronal vesicular glutamate transporter.
- Transcriptional regulation of rat Na(+)/H(+) exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor.
- Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor.
- Molecular cloning of murine sodium-phosphate cotransporter type IIb (Na/P(i)-IIb) gene promoter and characterization of gene structure.
- Molecular cloning of the murine PHEX gene promoter.
- Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine.
- Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine.
- Expression of rat, renal NHE2 and NHE3 during postnatal development.
- Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (S...
- Differential regulation of renal sodium-phosphate transporter by glucocorticoids during rat ontogeny.
- Characterization of cis-elements required for osmotic Response of rat Na(+)/H(+) exchanger-2 (NHE-2) gene.
- Nutritional management of pediatric Gastrointestinal disorders.
- The role of nutrition in the overall management of pediatric patients.
- Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion Disease.
- Molecular cloning and characterization of the rat NHE-2 gene promoter.
- Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.
- Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated.
- Ontogeny of basolateral membrane sodium-hydrogen exchange (NHE) activity and mRNA expression of NHE-1 and NHE-4 in rat kidney and jejunum.
- The sulfone Syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris.
- Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium.
- Dietary regulation of the renal sodium-phosphate (Na+/Pi) transporter during early ontogeny in the rat.
- Posttranscriptional mechanisms regulate ontogenic changes in rat renal sodium-phosphate transporter.
- The molecular defect in the renal sodium-phosphate transporter expression pathway of Gyro (Gy) mice is distinct from that of hypophosphatemic (Hyp) mice.
- Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2).
- Decreased intestinal CYP3A in celiac Disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism.
- Kinetic characterization of a stably expressed novel Na+/H+ exchanger (NHE-2).
Schools
Ankara Universitesi Tip Fakultesi
Royal College Physical
Hershey Med CtrPenn St University
University Ia
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Biliary Atresia
- Cholecystitis and Gallstones
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Doctors Specialties
- Pediatric Gastroenterology
Accepted Insurances
- Aetna HMO
- Aetna Savings Plus of AZ
- Choice Plus POS II
- Assurant Health
- Open Access
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Medicare Advantage PFFS
- First Health (Coventry Health Care) PPO
- Golden Rule
- Choice Care PPO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Fellow (FAAP)
Education
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University of Iowa Hospitals and Clinics -
Penn State University -
Ankara University Faculty of Medicine
Hospital
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TMC Healthcare
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