Professor, Pediatrics, Keck School of Medicine of the University of So California
Hematology
Dr. Fatih M. Uckun, MD
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Fatih M. Uckun is an expert in the field of Hematology. Fatih Uckun is also published. He has 100 publications published. The lastest publication: "Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials.'
Publications
- Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency.
- CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule.
- CD22ΔE12 as a molecular target for RNAi therapy.
- Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery.
- A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies.
- A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR.
- CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells.
- Vaginal microbicides and their delivery platforms.
- Absence of Genomic Ikaros/IKZF1 Deletions in Pediatric B-Precursor Acute Lymphoblastic Leukemia.
- KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION.
- Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia.
- Protein kinase inhibitors against malignant lymphoma.
- Novel Bruton's tyrosine kinase inhibitors currently in development.
- Biotargeted nanomedicines for cancer: six tenets before you begin.
- Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia.
- CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.
- Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protei...
- CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.
- STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.
- Clinical potential of targeting Bruton's tyrosine kinase.
- Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases.
- Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1.
- Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and...
- Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion.
- Vaginal contraceptive activity of a chelated vanadocene.
- Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple lo...
- A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermici...
- Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides.
- PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide.
- Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
- Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
- Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein.
- Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
- Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits.
- In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats.
- Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits.
- Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
- Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity.
- Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice.
- Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats.
- Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitor...
- Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 is...
- In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice.
- A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiour...
- Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bo...
- In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), ...
- Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions.
- Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.
- CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-de...
- Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells.
- A degradation study of a series of chloromethyl and diazomethyl ketone anti-leukemic agents.
- Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione.
- Synthesis and Structure of Bis(pi-cyclopentadienyl)vanadium(IV) 1,10-Phenanthroline and 2,2'-Bipyridine Compounds and Their Interactions with Artificial Membranes.
- Constitutive Function of the Ikaros Transcription Factor in Primary Leukemia Cells from Pediatric Newly Diagnosed High-Risk and Relapsed B-precursor ALL Patients.
- Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates.
- Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine.
- Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases.
- Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine.
- Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus.
- Effect of change in nucleoside structure on the activation and antiviral activity of phosphoramidate derivatives.
- Stereochemical influence on lipase-mediated hydrolysis and biological activity of stampidine and other stavudine phosphoramidates.
- A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine.
- Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine.
- A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice.
- Therapeutic potential of inhibiting Bruton''s tyrosine kinase, (BTK).
- Rational drug design of multifunctional phosphoramidate substituted nucleoside analogs.
- GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion.
- Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children''s Cancer Group.
- Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children''s Canc...
- Synthesis and anti-HIV activity of carbamates of antiviral agent stavudine.
- Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release.
- Augmentation of the antileukemia potency of total-body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK).
- Meta analysis of advanced cancer survival data using lognormal parametric fitting: a statistical method to identify effective treatment protocols.
- In vivo toxicity, pharmacokinetic features, and immunogenicity of B43(Anti-CD19)-genistein immunoconjugate in mice and non-human primates.
- Recent advances in JAK3 kinase inhibitors.
- 2,4,6-Trihydroxy-alpha-p-methoxyphenylacetophenone (Compound D-58) is a potent inhibitor of allergic reactions.
- Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice.
- Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles.
- Bioavailability and pharmacokinetic features of etoposide in childhood acute lymphoblastic leukemia patients.
- Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia.
- High-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors.
- Stereochemistry as a major determinant of the anti-HIV activity of chiral naphthyl thiourea compounds.
- Structure-based design of novel anticancer agents.
- Rational design of potent and selective EGFR tyrosine kinase inhibitors as anticancer agents.
- Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhe...
- Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model.
- Recipient preconditioning and donor-specific bone marrow infusion in a pig model of total bowel transplantation.
- CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group...
- Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children''s Cancer Group Study.
- Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials.
- Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review.
- Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model.
- Rationally designed anti-mitotic agents with pro-apoptotic activity.
- Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leuk...
- Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobuline...
- Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice.
- Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
- In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N''-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleos...
- Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia.
Schools
Medizinische Fak Heidelberg Germany
Doctors Specialties
- Hematology
Accepted Insurances
Education
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University of Minnesota at Fairview -
Ruprecht Karl University Faculty of Medicine
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