Physician
Internal Medicine
Dr. Ethan M. Shevach, MD
Ethan Shevach practices Internal Medicine. He studied medicine at Boston University School of Medicine. Boston University School of Medicine is ranked 30/52 in Research/PrimaryCare. He received awards:"Elected Member". Ethan Shevach is also published. He has 101 publications published. The lastest publication: "CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.'
Publications
- Helios Controls a Limited Subset of Regulatory T Cell Functions.
- William E. Paul 1936-2015.
- IFN-α/β Receptor Signaling Promotes Regulatory T Cell Development and Function under Stress Conditions.
- Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells.
- Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.
- TCR signaling fuels Treg cell suppressor function.
- Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8.
- tTregs, pTregs, and iTregs: similarities and differences.
- Antigen-Specific Induced T Regulatory Cells Impair Dendritic Cell Function via an IL-10/MARCH1-Dependent Mechanism.
- Modulation of Treg cells/T effector function by GITR signaling is context-dependent.
- The percentage of Foxp3(+) Helios(+) T regulatory cells positively correlates with disease activity in systemic lupus erythematosus.
- Regulation of the Expression of GARP/Latent TGF-β1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation.
- Eos, goddess of treg cell reprogramming.
- Regulatory T cells: recommendations to simplify the nomenclature.
- Application of IL-2 therapy to target T regulatory cell function.
- The deubiquitinase CYLD targets Smad7 to regulate TGF-{beta} signaling and the development of regulatory T cells.
- A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease.
- Polyclonal Tregs Modulate T Effector Cell Trafficking.
- IL-2 Controls the Stability of Foxp3 Expression in TGF-{beta}-Induced Foxp3+ T Cells In Vivo.
- The resurrection of T cell-mediated suppression.
- Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.
- Biological functions of regulatory T cells.
- TGF-Beta to the rescue.
- Autoantibodies in Scurfy mice and IPEX patients recognize keratin 14.
- Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.
- Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival.
- GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
- Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their puri...
- Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.
- Mechanisms of foxp3+ T regulatory cell-mediated suppression.
- Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
- Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.
- Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease.
- Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function.
- Immunology. Regulating suppression.
- CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
- Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells.
- Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.
- The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
- Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
- Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regula...
- Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells.
- Foxp3+ regulatory T cells: selfishness under scrutiny.
- Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses.
- Nonredundant roles for Stat5a/b in directly regulating Foxp3.
- Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells.
- Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
- CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence.
- From vanilla to 28 flavors: multiple varieties of T regulatory cells.
- TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
- Activated CD4+CD25+ T cells selectively kill B lymphocytes.
- CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells.
- Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function.
- Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells.
- In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.
- Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
- Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.
- Fatal attraction: tumors beckon regulatory T cells.
- Regulatory/suppressor T cells in health and disease.
- Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.
- Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance.
- Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice.
- The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.
- Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy.
- The role of suppressor T cells in regulation of immune responses.
- Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.
- CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.
- Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 rece...
- Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease.
- CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
- Cutting Edge: IL-10-producing CD4+ T cells mediate tumor rejection.
- Endogenous Mouse Mammary Tumor Viruses (Mtv): New Roles for an Old Virus in Cancer, Infection, and Immunity.
- Labeling cells in microtiter plates for determination of [3H]thymidine uptake.
- Spatial genome organization during T-cell differentiation.
- Do parasitic infections break T-cell tolerance and trigger autoimmune disease?
- Regulatory T cells. Introduction.
- Induction of transplantation tolerance in guinea pigs by spleen allografts. I. Operative techniques and clinical results.
- Alloantiserum-induced inhibition of immune response gene product function. II. Genetic analysis of target antigens.
- Alloantiserum-induced inhibition of immune response gene product function. I. Cellular distribution of target antigens.
- Receptors for complement and immunoglobulin on human and animal lymphoid cells.
- The distribution of histocompatibility antigens on T and B cells in the guinea pig.
- CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.
- An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.
- Adhesion molecules: a rheumatologic perspective.
- Microbial products induce autoimmune disease by an IL-12-dependent pathway.
- Vascular cell adhesion molecule-1 is expressed by cortical thymic epithelial cells and mediates thymocyte adhesion. Implications for the function of alpha4beta1 (VLA4)...
- Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog.
- Immune deviation--the third dimension of nondeletional T cell tolerance.
- IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.
- IL-12 unmasks latent autoimmune disease in resistant mice.
- Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells.
- Activated B cells express CD28/B7-independent costimulatory activity.
- Influence of prolactin and growth hormone on the activation of dwarf mouse lymphocytes in vivo.
- Identification by analytical flow cytometry of prolactin receptors on immunocompetent cell populations in the mouse.
- Gamma delta T cells promote CD4 and CD8 expression by SCID thymocytes.
- Aberrant expression of the very early activation antigen on MRL/Mp-lpr/lpr lymphocytes.
- Influence of bromocriptine administration to mothers on the development of pup thymocyte and splenocyte subsets and on mitogen-induced proliferation in the mouse.
- Post-thymectomy organ-specific autoimmunity: enhancement by cyclosporine A and inhibition by IL-2.
- Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development.
- Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity.
Schools
Boston University School Of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
-
Boston University School of Medicine
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