Professor, Pediatrics, Massachusetts General Hospital, Harvard Medical School
Pediatrics
Dr. Emmett V. Schmidt, MD
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Dr. Emmett V. Schmidt is an expert in the field of Pediatrics. He attended Duke University School of Medicine. Duke University School of Medicine is one of the top medical schools in the US. Duke University School of Medicine is ranked 8/29 in Research/PrimaryCare. Emmett Schmidt has written publications. He has 81 publications published with PubMed. The lastest publication is: 'Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation.'
Publications
- Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics.
- Serum levels of anti-type VII collagen antibodies detected by enzyme-linked immunosorbent assay in patients with epidermolysis bullosa acquisita are correlated with th...
- The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast...
- High-dose mannose-binding lectin therapy for Ebola virus infection.
- A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus.
- Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression.
- Complex role of mannose-binding lectin in infectious diseases.
- Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway.
- c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation.
- Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity.
- Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression.
- Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction.
- Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.
- hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic ...
- Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.
- Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.
- The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer.
- Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth.
- Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.
- Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer.
- Genes involved in breast cancer progression: analysis of global changes in gene expression or retroviral tagging?
- Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system.
- Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.
- Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors.
- Assessment of in vitro growth potential of hepatocytes expressing hepatocyte growth factor in an autocrine fashion.
- Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha.
- MYC family ties.
- Inhibitory effect of hepatocyte growth factor on metastasis of hepatocellular carcinoma in transgenic mice.
- Close linkage of a transgene insertion site to the steel (Sl) locus on mouse chromosome 10.
- Animal model of human disease. Skeletal hyperostoses: viral induction of avian osteopetrosis.
- Induction of anemia by avian leukosis viruses of five subgroups.
- Association of 3' terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis.
- Avian osteopetrosis virus induces proliferation of cultured bone cells.
- Zidovudine-associated embryonic toxicity in mice.
- B-less: a strain of profoundly B cell-deficient mice expressing a human lambda transgene.
- Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma.
- Down-regulation of c-myc mRNA after completion of liver regeneration in transgenic mice expressing hepatocyte growth factor in liver.
- Overexpression of CD3 eta during thymic development does not alter the negative selection process.
- Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.
- CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae.
- A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
- Hepatocyte growth factor regulates transforming growth factor alpha in HepG2 hepatic cells.
- Coordination of cell growth with cell division.
- Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance.
- Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice.
- Enhanced survival of transgenic hepatocytes expressing hepatocyte growth factor in hepatocyte tissue engineering.
- cis-dominance of rat atrial natriuretic factor gene regulatory sequences in transgenic mice.
- Inhibitory effect of hepatocyte growth factor against FaO hepatocellular carcinoma cells may be associated with changes of intracellular signalling pathways mediated b...
- Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells.
- A rat gastrin-human gastrin chimeric transgene directs antral G cell-specific expression in transgenic mice.
- IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
- Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.
- Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels.
- Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.
- The cytomegalovirus enhancer: a pan-active control element in transgenic mice.
- Happenstance, circumstance or enemy action: cyclin D1 in breast, eye and brain.
- The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues.
- Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast.
- Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.
- In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53.
- The role of c-myc in cellular growth control.
- Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression.
- Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes.
- Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4.
- Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.
- Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice.
- The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prosta...
- Cyclin D1 (PRAD1) alternative transcript b: full-length cDNA cloning and expression in breast cancers.
- Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.
- Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene.
- Transgenic expression of hepatitis C virus structural proteins in the mouse.
- An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc.
- Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (eIF4E) and their function in growth regulation.
- Regulation of cyclin D1 and p16(INK4A) is critical for growth arrest during mammary involution.
- Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors.
- Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland.
- The role of c-myc in regulation of translation initiation.
- Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication.
- Genome-wide analysis of YY2 versus YY1 target genes.
- Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.
Schools
Duke University
Chldns Hospital Center
Mass Gen Hospital
Children39s Hospital Boston
Doctors Specialties
- Pediatrics
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- GHI PPO
- Choice Care PPO
Education
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Boston Children's Hospital -
Duke University School of Medicine
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