Professor, Medicine, University of California, Irvine College of Medicine
Endocrinology
Dr. Ellis R. Levin, MD
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Ellis Levin practices Endocrinology. He attended Jefferson Medical College. He received 10 awards: "Professor, Above Scale Distinction in the UC system", "Solomon A Berson Award Distinguished Research Lectureship", "Honorary Professor of Pharmacology", "Top Physicians in America", "Athalie Clark Research Award", "Faculty Award-Excellence in Research", "4th Annual Distinguished Physiologist Lectureship", "Outstanding Scientific and Technical Award", "Excellence in Teaching Award" and "Senior Fellowship". Ellis Levin is a published doctor and has 110 publications published. The lastest was: 'Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.'
Publications
- Extranuclear estrogen receptor's roles in physiology: lessons from mouse models.
- Translating extranuclear steroid receptor signaling to clinical medicine.
- Membrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function.
- Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.
- Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast Cancer by silencing manganese superoxide dismutase (MnSOD).
- ERβ Selective Agonist Inhibits Angiotensin-Induced Cardiovascular Pathology in Female Mice.
- Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models In Vitro and In Vivo.
- Estrogen Modulates Metabolic Pathway Adaptation to Available Glucose in Breast Cancer Cells.
- Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast Cancer.
- Elusive extranuclear estrogen receptors in breast Cancer.
- DHHC-7 and 21 are palmitoylacyltransferases for sex steroid receptors.
- Minireview: Recent Advances in Extranuclear Steroid Receptor Actions.
- Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.
- Estrogen receptor-beta prevents cardiac fibrosis.
- Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.
- Plasma membrane estrogen receptors.
- Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair.
- G protein-coupled receptor 30: estrogen receptor or collaborator?
- Developmental phenoType of a membrane only estrogen receptor alpha (MOER) mouse.
- Hormone action and breast Cancer.
- Rapid signaling by steroid receptors.
- Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin.
- Extranuclear steroid receptors: nature and actions.
- A conserved mechanism for steroid receptor translocation to the plasma membrane.
- Nature of functional estrogen receptors at the plasma membrane.
- Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide.
- Functional estrogen receptors in the mitochondria of breast Cancer cells.
- Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms.
- Estrogen signaling in the cardiovascular system.
- Estrogen receptors and cell signaling.
- Integration of the extranuclear and nuclear actions of estrogen.
- Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1.
- Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta.
- Requirements for estrogen receptor alpha membrane localization and function.
- Plasma membrane estrogen receptors exist and functions as dimers.
- BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast Cancer.
- Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor.
- Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.
- Proximal events in signaling by plasma membrane estrogen receptors.
- Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology.
- Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide.
- Estrogen receptor-beta and the cardiovascular system.
- Cellular functions of plasma membrane estrogen receptors.
- ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions.
- Estrogen reduces Lipid content in the liver exclusively from membrane receptor signaling.
- [New concepts on hormone dependence in breast Cancer].
- Estrogen receptor isoforms and progestin hormone dependence in a mouse mammary tumor model.
- Receptors characterization of intraperitoneally N-nitroso-N-methylurea-induced mammary tumors in rats.
- Natriuretic peptides.
- Transfer of amino acids and urea to and from the subarachnoid space.
- Dopamine regulates canine plasma beta-endorphin-immunoreactivity levels.
- Opposite effect of a cAMP analogue on tumoral growth related to hormone dependence of a murine mammary tumor.
- Characterization of rat uterine estrogen receptors in vivo.
- Endothelins as cardiovascular peptides.
- Morphine and naloxone: effects on beta-endorphin immunoreactivity in canine plasma and secretions from rat pituitaries.
- IGF I induction of p53 requires activation of MAP kinase in cardiac muscle cells.
- Clinical review 53: The endocrinology of vasoactive peptides: synthesis to function.
- Accumulation of neutral amino acids by Streptococcus faecalis. Energy coupling by a proton-motive force.
- Effects on mouse uterus of three antitumoral drugs acting upon estrogen and progesterone receptors directly and through other transduction pathways.
- The in vitro effects of endogenous opiates on natural killer cells, antigen-specific cytolytic T cells, and T-cell subsets.
- Endothelin receptors on cultured fetal rat diencephalic glia.
- Natriuretic peptides and hypertension.
- Editorial: Endothelin-1, prostaGlandin F 2 alpha, and the corpus luteum--the crisis of lysis.
- Evaluation of a displacement assay with tamoxifen as prognostic indicator in breast-Cancer patients with estrogen-receptor-positive tumors.
- Displacement by tamoxifen of the estradiol-estrogen receptor binding: a functional assay for breast Cancer studies.
- Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor.
- Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor.
- Cell localization, physiology, and nongenomic actions of estrogen receptors.
- Increased capillary permeability induced by human follicular fluid: a hypothesis for an ovarian origin of the hyperstimulation syndrome.
- Atrial natriuretic Peptide secretion from fetal rat diencephalon in culture.
- Atrial natriuretic factor: neuromodulator of the central nervous system regulation of blood pressure.
- Atrial natriuretic factor is detectable in human cerebrospinal fluid.
- Insulin stimulates Thyroid hormone receptor alpha gene expression in cultured bovine aortic endothelial cells.
- Studies of the penetration of the blood brain barrier by atrial natriuretic factor.
- Atrial natriuretic factor-induced vasodepression occurs through central nervous system.
- Insulin stimulates production and secretion of endothelin from bovine endothelial cells.
- Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF.
- Natriuretic peptide C-receptor: more than a clearance receptor.
- Atrial natriuretic peptide and endothelin: Interactions in the central nervous system and the periphery.
- Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for Cancer growth and ulcer healing.
- Endothelin increases atrial natriuretic peptide production in cultured rat diencephalic neurons.
- Natriuretic peptide receptors in cultured rat diencephalon.
- Nuclear receptor versus plasma membrane oestrogen receptor.
- Rapid actions of plasma membrane estrogen receptors.
- Central nervous system mediated vasodepressor action of atrial natriuretic factor.
- Decreased atrial natriuretic factor receptors and impaired cGMP generation in glomeruli from the cardiomyopathic hamster.
- PGE2 and PGI2 inhibit ET-1 secretion from endothelial cells by stimulating particulate guanylate cyclase.
- High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells.
- Oestrogen and progesterone inhibit the stimulated production of endothelin-1.
- Arginine vasopressin stimulates atrial natriuretic peptide gene expression and secretion from rat diencephalic neurons.
- ProstaGlandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.
- Insulin stimulates endothelin binding and action on cultured vascular smooth muscle cells.
- Brain and atrial natriuretic peptides bind to common receptors in brain capillary endothelial cells.
- Atrial and brain natriuretic peptides stimulate the production and secretion of C-Type natriuretic peptide from bovine aortic endothelial cells.
- Egr-1 activates basic fibroblast growth factor transcription. Mechanistic implications for astrocyte proliferation.
- Astrocyte progression from G1 to S phase of the cell cycle depends upon multiple protein interaction.
- Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis.
- Role of vascular endothelial cell growth factor in Ovarian Hyperstimulation Syndrome.
- Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor. Potential role in the inhibition of astrocyte proliferation.
- Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor.
- Membrane oestrogen receptor alpha signalling to cell functions.
- Estrogen receptors outside the nucleus in breast Cancer.
- Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion.
- Estrogen and progesterone inhibit vascular smooth muscle proliferation.
- Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation.
- Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.
- Natriuretic peptides inhibit G protein activation. Mediation through cross-talk between cyclic GMP-dependent protein kinase and regulators of G protein-signaling prote...
- Plasma membrane estrogen receptors signal to antiapoptosis in breast Cancer.
- Estrogen signals to the preservation of endothelial cell form and function.
Schools
Thomas Jefferson University
Thos Jefferson University Hospital
Vet Affairs Med Center W La
Conditions Treated
- Adrenal Incidentaloma
- Diabetes Type 2
- Goiter
- Hyperaldosteronism
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Doctors Specialties
- Endocrinology
Accepted Insurances
- Aetna
- CHAMPVA
- GEHA
- Medicare MCR
- TriWest Champus
Awards
- Professor, Above Scale Distinction in the UC system
- Solomon A Berson Award Distinguished Research Lectureship
- Honorary Professor of Pharmacology
- Top Physicians in America
- Athalie Clark Research Award
- Faculty Award-Excellence in Research
- 4th Annual Distinguished Physiologist Lectureship
- Outstanding Scientific and Technical Award
- Excellence in Teaching Award
- Senior Fellowship
Education
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VA Greater Los Angeles Healthcare System -
Thomas Jefferson University -
Jefferson Medical College
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