Professor, Pediatrics - Human Gene Therapy, Stanford University Medical Center
Pediatric Rheumatology
Dr. Elizabeth D. Mellins, MD
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Doctor Elizabeth D. Mellins, MD practices Pediatric Rheumatology. She studied medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Elizabeth Mellins is a published doctor and has 99 publications published. The lastest was: 'Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM.'
Publications
- Altered signaling in systemic juvenile idiopathic arthritis monocytes.
- Comparison of biomarkers for systemic juvenile idiopathic arthritis.
- Alternative pathways of osteoclastogenesis in inflammatory arthritis.
- The MHC Class II Cofactor HLA-DM Interacts with Ig in B Cells.
- Assembly and Architecture of the EBV B Cell Entry Triggering Complex.
- Susceptibility to HLA-DM is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.
- Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.
- Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.
- The IL-23/IL-17 axis in psoriatic arthritis.
- CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy.
- Transgene expression in various organs post BM-HSC transplantation.
- B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.
- Comparison of transduction efficiency among various lentiviruses containing GFP reporter in BM-HSC transplantation.
- Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic l...
- Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.
- Pulse-Chase Analysis for Studies of MHC Class II Biosynthesis, Maturation, and Peptide Loading.
- HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
- Hierarchy of risk of childhood onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
- An Insertion Mutant in DQA1*0501 Restores Susceptibility to HLA-DM: Implications for Disease Associations.
- Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.
- Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.
- Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.
- Urine Peptidomic and Targeted Plasma Protein Analyses in the Diagnosis and Monitoring of Systemic Juvenile Idiopathic Arthritis.
- Macrophage activation syndrome: advances towards understanding pathogenesis.
- Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis.
- Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states.
- Precarious balance: Th17 cells in host defense.
- Urine peptidomics for clinical biomarker discovery.
- Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.
- Breaking old paradigms: Th17 cells in autoimmune arthritis.
- T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.
- Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM.
- Modulation of peripheral B cell tolerance by CD72 in a murine model.
- Posttranslational regulation of I-Ed by affinity for CLIP.
- Clinical research networks: a step towards evidence-based practice in pediatric rheumatology.
- Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells.
- DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
- Medicine on a need-to-know basis.
- Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.
- Selective developmental defects of cord blood antigen-presenting cell subsets.
- Role of pediatric and internist rheumatologists in treating children with rheumatic diseases.
- Bordetella pertussis infection of primary human monocytes alters HLA-DR expression.
- Access to pediatric rheumatology care in the United States.
- Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor.
- Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides.
- Cytokines elicited by T cell epitopes from a synovial autoantigen: altered peptide ligands can reduce interferon-gamma and interleukin-10 production.
- Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus.
- Point mutations in or near the antigen-binding groove of HLA-DR3 implicate class II-associated invariant chain peptide affinity as a constraint on MHC class II polymor...
- Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM.
- Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.
- Latent cytomegalovirus down-regulates major histocompatibility complex class II expression on myeloid progenitors.
- Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels.
- Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implications.
- I-Ag7 is subject to post-translational chaperoning by CLIP.
- Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development.
- Cathepsin G: roles in antigen presentation and beyond.
- Plasticity of T-cell phenotype and function: the T helper type 17 example.
- Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.
- DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechan...
- A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. 1990.
- Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus.
- Influenza A virus elevates active cathepsin B in primary murine DC.
- Candidate early predictors for progression to joint damage in systemic juvenile idiopathic arthritis.
- Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression.
- The role of the MHC in autoimmunity: an overview.
- Rapid signaling to B cells by antigen-specific T cells requires CD18/CD54 interaction.
- A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.
- Decreasing severity of chronic uveitis in children with pauciarticular arthritis.
- Psychosomatic musculoskeletal pain in childhood: clinical and psychological analyses of 100 children.
- Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.
- Mutations affecting antigen processing impair class II-restricted allorecognition.
- Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.
- A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.
- Painless juvenile rheumatoid arthritis.
- Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck).
- mRNA abundance, rather than differences in subunit assembly, determine differential expression of HLA-DR beta 1 and -DR beta 3 molecules.
- Importance of HLA-DQ and -DP restriction elements in T-cell responses to soluble antigens: mutational analysis.
- A single amino acid substitution in the human histocompatibility leukocyte antigen DR3 beta chain selectively alters antigen presentation.
- The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.
- Analysis of HLA-DMB mutants and -DMB genomic structure.
- Mediation by HLA-DM of dissociation of peptides from HLA-DR.
- Mutational analysis of two DR alpha residues involved in dimers of HLA-DR molecules.
- An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.
- A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.
- Predicting remission in juvenile rheumatoid arthritis with methotrexate treatment.
- Eosinophilic fasciitis in children frequently progresses to scleroderma-like cutaneous fibrosis.
- Developing and shedding inhibitions: how MHC class II molecules reach maturity.
- Mechanisms by which HLA-class II molecules protect human B lymphoid tumour cells against NK- and LAK-mediated cytolysis.
- Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.
- Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens.
- Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function.
- Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization.
- DR/CLIP (class II-associated invariant chain peptides) and DR/peptide complexes colocalize in prelysosomes in human B lymphoblastoid cells.
- Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM.
- Modulation of major histocompatibility class II protein expression by varicella-zoster virus.
- Accessory molecules for MHC class II peptide loading.
- Determination of the HLA-DM interaction site on HLA-DR molecules.
- pH stability of HLA-DR4 complexes with antigenic peptides.
Schools
Harvard Medical School
University Of Colorado
University of Washington
Chldns Ortho Hospital
Doctors Specialties
- Pediatric Rheumatology
Accepted Insurances
Education
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University of Washington -
University of Colorado -
Harvard Medical School
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