Associate Professor, Medicine-Brigham and Women's Hospital, Harvard Medical School
Family Medicine
Dr. Elizabeth B. Klerman, MD
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Elizabeth B. Klerman, MD is an expert in the field of Family Medicine. She researched medicine at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Elizabeth B. Klerman, MD is a published MD. She published 50 publications, including: 'Circadian and homeostatic influences on sleep in the squirrel monkey: sleep after sleep deprivation.'
Publications
- Absence of Central Circadian Pacemaker Abnormalities in Humans With Loss of Function Mutation in Prokineticin 2.
- Mammalian rest/activity patterns explained by physiologically based modeling.
- Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing.
- Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep.
- Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle.
- Sleep misperception in healthy adults: implications for insomnia diagnosis.
- Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology.
- Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics.
- Absence of circadian rhythms of gonadotropin secretion in women.
- Ramelteon prior to a short evening nap impairs neurobehavioral performance for up to 12 hours after awakening.
- Abnormal sleep/wake dynamics in orexin knockout mice.
- Uncovering residual effects of chronic sleep loss on human performance.
- Taking the lag out of jet lag through model-based schedule design.
- Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.
- Age-related reduction in the maximal capacity for sleep--implications for insomnia.
- Measuring melatonin in humans.
- A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker.
- Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker.
- Developing mathematical models of neurobehavioral performance for the "real world".
- Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling.
- On mathematical modeling of circadian rhythms, performance, and alertness.
- Elevated body temperature during sleep in orexin knockout mice.
- Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular Mammalian circadian clock.
- Interindividual variation in sleep duration and its association with sleep debt in young adults.
- Clinical aspects of human circadian rhythms.
- Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker.
- Older people awaken more frequently but fall back asleep at the same rate as younger people.
- A statistical model of diurnal variation in human growth hormone.
- Photic resetting of the human circadian pacemaker in the absence of conscious vision.
- Comparisons of the variability of three markers of the human circadian pacemaker.
- Peak of circadian melatonin rhythm occurs later within the sleep of older subjects.
- Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects.
- EEG delta activity during undisturbed sleep in the squirrel monkey.
- Circadian rhythms of women with fibromyalgia.
- Circadian phase resetting in older people by ocular bright light exposure.
- Commentary: model building, quantitative testing, and model comparison.
- Circadian and sleep-dependent regulation of hormone release in humans.
- Do plasma melatonin concentrations decline with age?
- Linear demasking techniques are unreliable for estimating the circadian phase of ambulatory temperature data.
- Circadian and homeostatic influences on sleep in the squirrel monkey: sleep after sleep deprivation.
- Later endogenous circadian temperature nadir relative to an earlier wake time in older people.
- Nonphotic entrainment of the human circadian pacemaker.
- Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients.
- The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study.
- Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period.
- Suppression of melatonin secretion in some blind patients by exposure to bright light.
- Biological time series analysis using a context free language: applicability to pulsatile hormone data.
- Deconvolution of serum cortisol levels by using compressed sensing.
- Impact of common diabetes risk variant in MTNR1B on sleep, circadian and melatonin physiology.
Schools
Harvard Medical School
Doctors Specialties
- Internal Medicine
- Family Medicine
Accepted Insurances
Education
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Harvard Medical School
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