Professor, Neurosciences, UCSD School of Medicine
Pathology
Dr. Eliezer Masliah, MD
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Eliezer Masliah practices Pathology. Eliezer Masliah is a published physician. He has 101 papers published. The most current publication "Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease."
Publications
- Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.
- Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism.
- Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease.
- Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.
- Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.
- Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.
- Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats.
- Molecular Determinants of α-Synuclein Mutants' Oligomerization and Membrane Interactions.
- Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
- HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders.
- The Parkinson's Disease Mutant E46K Enhances Alpha-Synuclein Phosphorylation in Mammalian Cell-Lines, in Yeast and In Vivo.
- Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice.
- Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.
- Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.
- Antiretroviral therapy reduces neurodegeneration in HIV infection.
- Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
- Primary age-related tauopathy (PART): a common pathology associated with human aging.
- Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein.
- Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.
- Modulation of the maladaptive stress response to manage diseases of protein folding.
- Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.
- Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy.
- Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors.
- Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.
- ESCRT mediated uptake and degradation of brain targeted α-synuclein-single chain antibody attenuates neuronal degeneration in vivo.
- Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
- Silencing of Murine Transthyretin and Retinol Binding Protein Genes Have Distinct and Shared Behavioral and Neuropathologic Effects.
- A Neuroprotective Brain Penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer's Disease Pathology and Restores Neurogenesis.
- Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.
- Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
- α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.
- Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96.
- HIV protease inhibitor exposure predicts cerebral small vessel disease.
- TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.
- De novo prion aggregates trigger autophagy in skeletal muscle.
- Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy.
- Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.
- Role of Neurotrophic Factor Alterations in the Neurodegenerative Process in HIV Associated Neurocognitive Disorders.
- Impaired Neurogenesis by HIV-1-Gp120 is Rescued by genetic deletion of Fatty Acid Amide Hydrolase Enzyme.
- Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease.
- Chronic cerebrolysin administration attenuates neuronal abnormalities in the basolateral amygdala induced by neonatal ventral hippocampus lesion in the rat.
- Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.
- Structural Diversity of Alzheimer's Disease Amyloid-β Dimers and Their Role in Oligomerization and Fibril Formation.
- Alterations in the Levels of Vesicular Trafficking Proteins Involved in HIV Replication in the Brains and CSF of Patients with HIV-associated Neurocognitive Disorders.
- Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription.
- CB2 cannabinoid agonist enhanced neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis.
- The challenge of connecting the dots in the B.R.A.I.N.
- Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.
- Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice.
- Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes.
- Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.
- Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: Beyond cognition.
- In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase.
- Defining the conformational features of anchorless, poorly neuroinvasive prions.
- Neuropsychiatric Features of Frontal Lobe Dysfunction in Autopsy-Confirmed Patients with Lewy Bodies and "Pure" Alzheimer Disease.
- FOXO4 is necessary for neural differentiation of human embryonic stem cells.
- Molecular and pathologic insights from latent HIV-1 infection in the human brain.
- A progressive dopaminergic phenotype associated with neurotoxic conversion of ?-synuclein in BAC-transgenic rats.
- Phospholipase C{varepsilon} links G protein-coupled receptor activation to inflammatory astrocytic responses.
- Mapping the Subcellular Distribution of ?-Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinso...
- Immunotherapy for neurodegenerative diseases: Focus on ?-synucleinopathies.
- Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer.
- Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease.
- Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice.
- Axonopathy in an ?-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal-Truncated ?-Synuclein.
- Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD.
- Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort.
- A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.
- Role of α-Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus.
- Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration.
- Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits.
- Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.
- Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with lewy bodies.
- Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid.
- Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration.
- Alpha-synuclein induces alterations in adult neurogenesis in Parkinson'd disease models via p53-mediated repression of Notch1.
- In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.
- Alzheimer's Disease: Recent Advances and Future Perspectives.
- PGC-1α Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function.
- Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.
- Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.
- Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
- Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.
- Spongiform Change in Dementia With Lewy Bodies and Alzheimer Disease.
- The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders.
- Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy.
- Antioxidant Sestrin-2 Redistribution to Neuronal Soma in Human Immunodeficiency Virus-Associated Neurocognitive Disorders.
- Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin.
- Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor.
- Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders.
- A Novel Triple Repeat Mutant Tau Transgenic Model That Mimics Aspects of Pick's Disease and Fronto-Temporal Tauopathies.
- Proteomic analysis of highly prevalent amyloid a amyloidosis endemic to endangered island foxes.
- Immunotherapy for Alzheimer's disease: past, present and future.
- Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 - implications for dementia with Lewy bodies.
- Fatal pulmonary embolism update: 10 years of autopsy experience at an academic medical center.
- α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.
- HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.
- Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.
- Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum.
Doctors Specialties
- Pathology
Accepted Insurances
Hospital
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UC San Diego Health
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