Chair, Infectious Diseases, St. Jude Children's Research Hospital
Pediatric Infectious Disease
Dr. Elaine I. Tuomanen, MD
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Elaine Tuomanen is an expert in the field of Pediatric Infectious Disease. Elaine Tuomanen is a published doctor. She published 100 publications, including: 'Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system.'
Publications
- Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior.
- Correlation Between the Interval of Influenza Virus Infectivity and Results of Diagnostic Assays in a Ferret Model.
- Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function.
- Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions.
- Type I Interferon Protects against Pneumococcal Invasive Disease by Inhibiting Bacterial Transmigration across the Lung.
- Control of Virulence by Small RNAs in Streptococcus pneumoniae.
- Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin.
- Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza.
- PGRPs kill with an ancient weapon.
- Inhibition of T cells provides protection against early invasive pneumococcal disease.
- Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease.
- Pneumococcal pathogenesis: "innate invasion" yet organ-specific damage.
- Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae.
- Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza.
- The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis.
- Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to s...
- Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.
- Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae.
- Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
- The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls.
- Calcium efflux is essential for bacterial survival in the eukaryotic host.
- Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
- Cytokine secretion requires phosphatidylcholine synthesis.
- A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.
- Planning and implementation of an infection control training program for healthcare providers in Latin America.
- Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae.
- Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice.
- Adapting a diet from sugar to meat: double-dealing genes of Streptococcus pyogenes.
- Cellular damage in bacterial meningitis: an interplay of bacterial and host driven toxicity.
- Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor.
- Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients.
- Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.
- Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide.
- Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease.
- Cell wall-mediated neuronal damage in early sepsis.
- Multifunctional role of choline binding protein G in pneumococcal pathogenesis.
- beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae.
- Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae.
- Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.
- Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans.
- Cephalosporin-resistant pneumococci and sickle cell disease.
- NMR assignment of the R2 domain of pneumococcal choline binding protein A (CbpA).
- Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model.
- Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae.
- Dual phases of apoptosis in pneumococcal meningitis.
- Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance.
- Tissue-specific contributions of pneumococcal virulence factors to pathogenesis.
- Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact.
- Microarray analysis of pneumococcal gene expression during invasive disease.
- Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain.
- Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines.
- Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance.
- Organ-specific models of Streptococcus pneumoniae disease.
- Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization.
- Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.
- Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein.
- Innate sensors for Gram-positive bacteria.
- Reprogramming the host response in bacterial meningitis: how best to improve outcome?
- Molecular analysis of antibiotic tolerance in pneumococci.
- Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.
- Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus.
- Molecular pathogenesis of pneumococcal pneumonia.
- Vancomycin-tolerant Streptococcus pneumoniae and its clinical significance.
- Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection.
- Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin.
- Pathogenesis of pneumococcal inflammation: otitis media.
- Mechanisms of antibiotic resistance and tolerance in Streptococcus pneumoniae.
- Role of novel choline binding proteins in virulence of Streptococcus pneumoniae.
- The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells.
- Regulation of growth inhibition at high temperature, autolysis, transformation and adherence in Streptococcus pneumoniae by clpC.
- The mystery of psaA and penicillin tolerance in Streptococcus pneumoniae.
- Host cell invasion by Streptococcus pneumoniae.
- Extracellular targeting of choline-binding proteins in Streptococcus pneumoniae by a zinc metalloprotease.
- Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium.
- Signal transduction by a death signal peptide: uncovering the mechanism of bacterial killing by penicillin.
- Molecular and cellular mechanisms for microbial entry into the CNS.
- Pathogenesis of pneumococcal pneumonia.
- Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
- Divergence in the background: hard to measure but the key to being the best of the best.
- Emergence of vancomycin tolerance in Streptococcus pneumoniae.
- Neuroprotection by a caspase inhibitor in acute bacterial meningitis.
- Pneumococcal licD2 gene is involved in phosphorylcholine metabolism.
- Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system.
- Molecular and cellular biology of pneumococcal infection.
- Molecular mechanisms of brain damage in bacterial meningitis.
- Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa.
- Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.
- Perspective: targeting nitric oxide in the adjuvant therapy of sepsis and meningitis.
- The biology of pneumococcal infection.
- Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia.
- Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria.
- Characterization of a recombinant fragment that contains a carbohydrate recognition domain of the filamentous hemagglutinin.
- Serotype-related differences in inflammatory response to Streptococcus pneumoniae in experimental meningitis.
- Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain.
- Surprise? Bacteria glycosylate proteins too.
- Molecular and cellular mechanisms of pneumococcal meningitis.
- Entry of pathogens into the central nervous system.
- Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.
- Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae.
Schools
McGill University Faculty of Medicine
Montreal Chldns Hospital
University Of Virginia
Doctors Specialties
- Pediatrics
- Pediatric Infectious Disease
Accepted Insurances
Education
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University of Virginia -
McGill University Faculty of Medicine
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