Professor of Ophthalmology, University Iowa College of Medicine
Ophthalmology
Dr. Edwin M. Stone, MD
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Edwin M. Stone, MD works in the field of Ophthalmology. He attended Baylor College of Medicine. He received 5 awards: "America's Top Doctors", "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Investigator" and "Fellow (FAAO)". Edwin Stone is also a published physician. He has 100 paper published. The most recent paper is: Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers. He accepts Medicare.
Publications
- Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.
- Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers.
- Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration.
- Full-Field Pupillary Light Responses, Luminance Thresholds, and Light Discomfort Thresholds in CEP290 Leber Congenital Amaurosis Patients.
- North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.
- Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly.
- Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11.
- Founder Effect of a c.828+3A>T Splice Site Mutation in Peripherin 2 (PRPH2) Causing Autosomal Dominant Retinal Dystrophies.
- Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal Degenerative diseases.
- Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related Macular degeneration.
- Stem Cells as Tools for Studying the Genetics of Inherited Retinal Degenerations.
- Transcriptomic analysis across nasal, temporal, and Macular regions of human neural retina and RPE/choroid by RNA-Seq.
- Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy.
- Comparison of Retinal and Choriocapillaris Thicknesses Following Sitting to Supine Transition in Healthy Individuals and Patients With Age-Related Macular Degeneration.
- Gene Therapy Using Stem Cells.
- Outer segment length in different best disease genotypes.
- Vitritis in Pediatric Genetic Retinal Disorders.
- The Membrane Attack Complex in Aging Human Choriocapillaris: Relationship to Macular Degeneration and Choroidal Thinning.
- CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
- Mechanical properties of murine and porcine ocular tissues in compression.
- Photoreceptor cells with profound structural deficits can support useful vision in mice.
- Structural and Biochemical Analyses of Choroidal Thickness in Human Donor Eyes.
- Inner and Outer Retinal Changes in Retinal Degenerations Associated with ABCA4 Mutations.
- Clinical and Electrophysiologic Characteristics of a Large Kindred with X-linked Retinitis Pigmentosa Associated with the RPGR Locus.
- THE VALUE OF Retinal IMAGING WITH INFRARED SCANNING LASER OPHTHALMOSCOPY IN PATIENTS WITH STARGARDT DISEASE.
- SubRetinal gene therapy of mice with Bardet-Biedl Syndrome type 1.
- Aflibercept Therapy for Exudative Age-related Macular Degeneration Resistant to Bevacizumab and Ranibizumab.
- Human Photoreceptor Outer Segments Shorten During Light Adaptation.
- Prioritization of Retinal Disease Genes: An Integrative Approach.
- Resolution of Mid-Peripheral Schisis in X-Linked Retinoschisis with the Use of Dorzolamide.
- Identification of Proteins that Interact with TANK Binding Kinase 1 and Testing for Mutations Associated with Glaucoma.
- Union makes strength: a worldwide collaborative genetic and clinical study to provide a comprehensive survey of RD3 mutations and delineate the associated phenotype.
- Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and Retinal differentiation.
- Wide-Field spectral-domain optical coherence tomography in patients and carriers of X-linked retinoschisis.
- Determining consequences of Retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor ...
- Assessing retinal structure in complete congenital stationary night Blindness and Oguchi disease.
- Proteomic analysis of vitreous biopsy techniques.
- Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor Degeneration.
- Confirmation of the association between the TCF4 risk allele and Fuchs endothelial corneal Dystrophy in patients from the Midwestern United States.
- Analysis of ASB10 variants in open angle Glaucoma.
- Intrinsic Protein-Protein Interaction-mediated and Chaperonin-assisted Sequential Assembly of Stable Bardet-Biedl Syndrome Protein Complex, the BBSome.
- Autosomal Recessive Retinitis Pigmentosa Due To ABCA4 Mutations: Clinical, Pathologic, and Molecular Characterization.
- Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4-associated Retinopathy Trials.
- BBS proteins interact genetically with the IFT pathway to influence SHH related phenotypes.
- Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.
- Autosomal Recessive Retinitis Pigmentosa caused by Mutations in the MAK Gene.
- TUDCA slows retinal Degeneration in two different mouse models of retinitis pigmentosa and prevents obesity in Bardet-Biedl syndrome type 1 mice.
- Three-dimensional Distribution of the Vitelliform Lesion, Photoreceptors, and Retinal Pigment Epithelium in the Macula of Patients With Best Vitelliform Macular Dystro...
- Automated discovery and quantification of image-based complex phenotypes: a twin study of drusen phenotypes in age-related Macular degeneration.
- Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations: Safety and Efficacy in 15 Children and Adults Followed Up to 3 Years.
- Residual Electroretinograms in Young Leber Congenital Amaurosis Patients with Mutations of AIPL1.
- Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of Retinitis pigmentosa.
- Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle Glaucoma.
- Photoreceptor Structure and Function in Patients with Congenital Achromatopsia.
- Human CRB1-associated retinal Degeneration: comparison with the rd8 Crb1-mutant mouse model.
- Elevated membrane attack complex in human Choroid with high risk complement factor H genotypes.
- Computational quantification of complex fundus phenotypes in age-related Macular degeneration and Stargardt disease.
- Genomics and the eye.
- Evaluation of variants in the selectin genes in age-related Macular degeneration.
- Copy number variations on chromosome 12q14 in patients with normal tension Glaucoma.
- Seroreactivity against aqueous-soluble and detergent-soluble Retinal proteins in posterior uveitis.
- Autosomal recessive vitelliform Macular dystrophy in a large cohort of vitelliform Macular dystrophy patients.
- Autosomal recessive best vitelliform Macular dystrophy: report of a family and management of early-onset neovascular complications.
- The phenotype of Severe Early Childhood Onset Retinal Dystrophy (SECORD) from mutation of RPE65 and differentiation from Leber congenital amaurosis.
- Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and Senior-Loken syndrome.
- Bilateral intravitreal injection of antiVascular endothelial growth factor therapy.
- Different inner Retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice.
- Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal Macular photoreceptors and rod function remaining.
- Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort.
- Copy number variations and primary open-angle Glaucoma.
- Anti-γ-enolase autoimmune Retinopathy manifesting in early childhood.
- Light aversion in mice depends on nonimage-forming irradiance detection.
- Ranibizumab therapy for neovascular age-related Macular degeneration.
- Patients with an acute zonal occult outer Retinopathy-like illness rapidly improve with valacyclovir treatment.
- Complement component C5a activates ICAM-1 expression on human Choroidal endothelial cells.
- Recurrence risks for Bardet-Biedl syndrome: Implications of locus heterogeneity.
- Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing children.
- Visual acuity in patients with Leber's congenital amaurosis and early childhood-onset Retinitis pigmentosa.
- Two novel CRX mutant proteins causing autosomal dominant Leber congenital amaurosis interact differently with NRL.
- Discovery and functional analysis of a Retinitis pigmentosa gene, C2ORF71.
- Differential Macular morphology in patients with RPE65-, CEP290-, GUCY2D-, and AIPL1-related Leber congenital amaurosis.
- Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.
- Retinal vascular abnormalities and dragged maculae in a carrier with a new NDP mutation (c.268delC) that caused severe Norrie disease in the proband.
- Clinical and genetic characterization of a Danish family with North Carolina Macular dystrophy.
- From the laboratory to the clinic: molecular genetic testing in pediatric ophthalmology.
- T-cell infiltration in autosomal dominant Neovascular inflammatory vitreoretinopathy.
- Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.
- The natural history of stargardt disease with specific sequence mutation in the ABCA4 gene.
- CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner Retinopathy.
- A new Macular dystrophy with anomalous vascular development, pigment spots, cystic spaces, and neovascularization.
- Visual impairment in the absence of dystroglycan.
- Which Leber congenital amaurosis patients are eligible for gene therapy trials?
- Harmonin in the murine retina and the Retinal phenotypes of Ush1c-mutant mice and human USH1C.
- Predicting the pathogenicity of RPE65 mutations.
- Peripapillary Retinal nerve fiber layer thinning in patients with autosomal recessive cone-rod dystrophy.
- CRB1 gene mutations are associated with keratoconus in patients with leber congenital amaurosis.
- Phenotypic variability due to a novel Glu292Lys variation in exon 8 of the BEST1 gene causing best Macular dystrophy.
- Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.
- Treatment of adult-onset acute Macular retinoschisis in enhanced s-cone syndrome with oral acetazolamide.
Schools
Baylor University
St Joseph Hospital
University Ia
Procedures Preformed
- Repair of Retinal Detachment or Retinal Tear
Conditions Treated
- Age-Related Macular Degeneration
- Benign Neoplasm of Choroid
- Benign Neoplasm of Eye
- Blindness
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Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Investigator
- Fellow (FAAO)
Education
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University of Iowa Hospitals and Clinics -
Baylor College of Medicine
Drug Facts
| NPI NUMBER | 1831182237 | |
| NPPES Provider LastName | STONE | |
| NPPES Provider FirstName | EDWIN | |
| NPPES Provider ZIPCode | 522421009 | |
| NPPES Provider State | IA | |
| Specialty Description | Ophthalmology | |
| Total Claim Count | 24.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1831182237 |
| Last Name Of The Provider | STONE |
| First Name Of The Provider | EDWIN |
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