Retired
Pediatric Hematology & Oncology
Dr. Edwin C. Douglass, MD
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Edwin Douglass practices Pediatric Hematology & Oncology. He went to medical school at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10/19 in Research/PrimaryCare. Edwin Douglass is a published doctor and has 98 publications published. The lastest was: 'Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).'
Publications
- Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21.
- Preradiation chemotherapy with methotrexate, cisplatin, 5-fluorouracil, and leucovorin for pediatric nasopharyngeal carcinoma.
- Myeloperoxidase promotor polymorphism and risk of hepatoblastoma.
- Development of ZD1839 in colorectal cancer.
- Phase I study of an oral formulation of ZD9331 administered daily for 28 days.
- Fibrolamellar hepatocellular carcinoma in children and adolescents.
- Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study.
- Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study.
- Extrarenal Wilms' tumor.
- An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
- Cytogenetic studies in non-African Burkitt lymphoma.
- Cytogenetic studies in ovarian cancer.
- Serial cytogenetic studies of nonendemic Burkitt's lymphoma cell lines.
- Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.
- Abnormalities of chromosomes 1 and 11 in Wilms' tumor.
- Chromosome 1 abnormalities: a common feature of pediatric solid tumors.
- An analysis of home-based oral rehydration therapy in the Kingdom of Lesotho.
- Phase II trial of ifosfamide in children with malignant solid tumors.
- Relapsed Wilms' tumor. Factors affecting survival and cure.
- Teratoid Wilms' tumor: the St Jude experience.
- Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors.
- Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity.
- Primary malignant rhabdoid tumor of the brain: clinical, imaging, and pathologic findings.
- Molecular analysis of chromosome 1 abnormalities in neuroblastoma.
- Malignant rhabdoid tumor of the liver. Evidence for epithelial differentiation.
- The potential for renal salvage in nonmetastatic unilateral Wilms' tumor.
- Evidence for clonal development of Wilms' tumor.
- Mechanisms of selective killing of neuroblastoma cells by natural killer cells and lymphokine activated killer cells. Potential for residual disease eradication.
- Development and characterization of pediatric osteosarcoma xenografts.
- Alveolar rhabdomyosarcoma with the t(2;13): cytogenetic findings and clinicopathologic correlations.
- A new cytogenetic finding in an epithelioid sarcoma, t(8;22)(q22;q11).
- Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.
- Phase I clinical and pharmacokinetic study of bisantrene in refractory pediatric solid tumors.
- Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
- Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor.
- Fatal refractory hyperkalemia due to tumor lysis during primary resection for hepatoblastoma.
- ZD9331 as second- or third-line therapy in patients with advanced colorectal cancer: a phase II multicenter trial.
- Central nervous system toxicity following the treatment of pediatric patients with ifosfamide/mesna.
- Amplification of the gli gene in childhood sarcomas.
- A phase II study to determine the efficacy and tolerability of intravenous ZD9331 in heavily pretreated patients with ovarian cancer.
- Solid alveolar rhabdomyosarcomas with the t(2;13). Report of two cases with diagnostic implications.
- Der(16)t(1;16)(q21;q13) in Wilms' tumor: friend or foe.
- Etoposide, ifosfamide, and cisplatin therapy for refractory childhood solid tumors. Response and toxicity.
- A second nonrandom translocation, der(16)t(1;16)(q21;q13), in Ewing sarcoma and peripheral neuroectodermal tumor.
- A specific chromosomal abnormality in rhabdomyosarcoma.
- Incontinentia pigmenti, a chromosomal instability syndrome, is associated with childhood malignancy.
- Ifosfamide in pediatric malignant solid tumors.
- Response of pediatric low grade gliomas to chemotherapy.
- Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma.
- Fractures in children treated with radiotherapy for soft tissue sarcoma.
- Effective cisplatin (DDP) based chemotherapy in the treatment of hepatoblastoma.
- Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma.
- Relationship between chemical-induced fragile sites and chromosomal breakpoints in malignant cells in children.
- Embryonal malignancies of unknown primary origin in children.
- Immunohistochemical and ultrastructural spectrum of hepatic sarcomas of childhood: evidence for a common histogenesis.
- Is renal salvage feasible in unilateral Wilms' tumor? Proposed computed tomographic criteria and their relation to surgicopathologic findings.
- Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.
- Significance of pulmonary computed tomography at diagnosis in Wilms' tumor.
- Refining therapeutic strategies for patients with resistant Wilm's tumor.
- Phase I study of 4'-deoxydoxorubicin (esorubicin) in children with malignant solid tumors.
- Treatment of unresectable or metastatic osteosarcoma with cisplatin or cisplatin-doxorubicin.
- Clinical studies of ifosfamide/mesna at St Jude Children's Research Hospital, 1983-1988.
- Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy.
- Pediatric nasopharyngeal carcinoma: long term follow-up of 29 patients.
- Local-regional non-rhabdomyosarcomatous soft tissue sarcomas of the head and neck.
- Malignant rhabdoid tumor: a highly malignant childhood tumor with minimal karyotypic changes.
- Neuraxis dissemination in pediatric brain tumors. Response to preirradiation chemotherapy.
- Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma.
- A phase II study of every other day high-dose ifosfamide in pediatric brain tumors: a Pediatric Oncology Group Study.
- There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncol...
- Phase I study of flavone acetic acid (NSC 347512, LM975) in patients with pediatric malignant solid tumors.
- Wilms' tumor: reduced-dose radiotherapy in advanced-stage Wilms' tumor with favorable histology.
- Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer.
- Relation of tumor-cell ploidy to survival in children with medulloblastoma.
- Reduced therapy for Wilms' tumor: analysis of treatment results from a single institution.
- Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the ...
- Failure of granulocyte-macrophage colony-stimulating factor to reduce febrile neutropenia in children with recurrent solid tumors treated with ifosfamide, carboplatin,...
- Phase I trial of ZD9331, a nonpolyglutamatable thymidylate synthase inhibitor, given as a 5-day continuous infusion to patients with refractory solid malignancies.
- A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.
- A phase I study of ifosfamide given on alternate days to treat children with brain tumors.
- High-activity 125I interstitial irradiation in the treatment of pediatric central nervous system tumors: a pilot study.
- Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study.
- Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma.
- High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas.
- Preirradiation chemotherapy with carboplatin and etoposide in newly diagnosed embryonal pediatric CNS tumors.
- Bilateral Wilms tumor. Review of outcome, associated abnormalities, and late effects in 36 pediatric patients treated at a single institution.
- The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34).
- Chemotherapy can convert unresectable hepatoblastoma.
- Therapeutic effects and pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor in childhood cancer patients receiving myelosuppressive ...
- Primary extracranial rhabdoid tumors. Clinicopathologic features and response to ifosfamide.
- Phase I study of escalating targeted doses of carboplatin combined with ifosfamide and etoposide in children with relapsed solid tumors.
- Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study.
- Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.
- Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.
- A phase I study of ifosfamide with Mesna given daily for 3 consecutive days to children with malignant solid tumors.
- Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations.
- CCND1 polymorphism and age of onset of hepatoblastoma.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
St Louis Chldns Hospital
Wyler Chldns Hospital
National Cancer Institute
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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University of Chicago -
University of Chicago Pritzker School of Medicine
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