Professor, Internal Medicine, Virginia Commonwealth University, Medical College of Virginia School of Medicine
Cardiology
Dr. Edward J. Lesnefsky Jr., MD
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Doctor Edward J. Lesnefsky Jr., MD works in the field of Cardiology. He attended University of Wisconsin School of Medicine and Public Health. He received awards:"Aging Selectively Decreases Oxidative Capacity in Interfibrillar Rat Mitochondria", "Midwest Section AFCR Award for Excellence in Research in Cardiovascular Disease", "First Place in the Fellowship Research Category Colorado ACP Associates Program" and "Fellow (FACC)". Edward Lesnefsky is a published MD. He has 56 publications published. The most current publication "Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury."
Publications
- Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release.
- Heart mitochondria and calpain 1: Location, function, and targets.
- Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury.
- Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during i...
- Apolipoprotein A1 regulates coenzyme q10 absorption, mitochondrial function, and infarct size in a mouse model of Myocardial infarction.
- Transient Complex I Inhibition at the Onset of Reperfusion by Extracellular Acidification Decreases Cardiac Injury.
- Chronic Inhibition of Phosphodiesterase 5 with Tadalafil Attenuates Mitochondrial Dysfunction in Type 2 Diabetic Hearts: Role of NO/SIRT1/PGC-1α Signaling.
- Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727.
- Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: role of complex I inhibition vs. depolarization of inner mitochondrial membrane.
- Transferring Protection: Adenosine as the Lone Ranger? : Editorial to: "Remote Cardioprotection by Transfer of Coronary Effluent from Ischemic Preconditioned Rabbit He...
- Cardioprotection by modulation of mitochondrial respiration during ischemia-reperfusion: Role of apoptosis-inducing factor.
- Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy due to Pulmonary Arterial Hypertension.
- Inhibition of apoptosis signal-regulating kinase 1 reduces Myocardial ischemia-reperfusion injury in the mouse.
- Multi-tasking: nuclear transcription factors with novel roles in the mitochondria.
- Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: Mechanisms and implications.
- Decreased Cytochrome c Oxidase Subunit VIIa in Aged Rat Heart Mitochondria: Immunocytochemistry.
- Activation of mitochondrial ?-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion.
- A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.
- Postconditioning modulates ischemia-damaged mitochondria during reperfusion.
- Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3.
- Mitochondrial-targeted signal transducer and activator of transcription (STAT3) protects against ischemia-induced changes in the electron transport chain and the gener...
- Depression, Stress, and Heart Disease in Earthquakes and Takotsubo Cardiomyopathy.
- Dietary nitrate supplementation protects against Doxorubicin-induced Cardiomyopathy by improving mitochondrial function.
- Left Ventricular Systolic Dysfunction Induced by Ventricular Ectopy: A Novel Model for PVC-induced Cardiomyopathy.
- Review of major measuring instruments in comorbid depression and Coronary heart disease.
- Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic Cardiomyopathy.
- Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.
- Assessing the presence and severity of depression in subjects with comorbid Coronary heart disease.
- Potential therapeutic benefits of strategies directed to mitochondria.
- Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia.
- Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging.
- Major depression and Coronary artery disease.
- Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating Heart by potassium and lidocaine cardioplegia: implications for cardioprotection.
- Reversible blockade of electron transport with amobarbital at the onset of reperfusion attenuates cardiac injury.
- Cardiolipin remodeling in the Heart.
- Function of mitochondrial Stat3 in cellular respiration.
- Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic Cardiomyopathy and heart failure.
- Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat Heart mitochondria.
- What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?
- Ischemic preconditioning does not protect via blockade of electron transport.
- Modulation of electron transport protects cardiac mitochondria and decreases Myocardial injury during ischemia and reperfusion.
- Reversible blockade of electron transport during ischemia protects mitochondria and decreases Myocardial injury following reperfusion.
- Reversal of mitochondrial defects before ischemia protects the aged Heart.
- Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain.
- Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat Heart mitochondria.
- Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat Hearts: a DNA microarray study.
- Blockade of electron transport during ischemia protects cardiac mitochondria.
- Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit Heart: role of cardiolipin.
- Ischemia-reperfusion injury in the aged Heart: role of mitochondria.
- Production of reactive oxygen species by mitochondria: central role of complex III.
- Cardioprotection by St Thomas' solution is mediated by protein kinase C and tyrosine kinase.
- Aging defect at the QO site of complex III augments oxyradical production in rat Heart interfibrillar mitochondria.
- Preservation of cardiolipin content during aging in rat Heart interfibrillar mitochondria.
- Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria.
- Acquired deficiency of tafazzin in the adult Heart: Impact on mitochondrial function and response to cardiac injury.
Schools
University of Wisconsin Madison
University Va Hosps
University Colo Health Science Center
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardiac Myocardial Perfusion Imaging
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Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Embolism and Thrombosis
- Aortic Valve Disease
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Doctors Specialties
- Cardiology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Pathway X Tier Hosp HealthKeepers DirectAccess VA
- HealthKeepers HMO
- KeyCare PPO
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Southern Health PPO
- Coventry Health Care of Virginia HMO
- Emblem Health
- First Health (Coventry Health Care) PPO
- Medicare Advantage PFFS
- Kaiser Permanente
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Mutual of Omaha
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Aging Selectively Decreases Oxidative Capacity in Interfibrillar Rat Mitochondria
- Midwest Section AFCR Award for Excellence in Research in Cardiovascular Disease
- First Place in the Fellowship Research Category Colorado ACP Associates Program
- Fellow (FACC)
Education
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University of Colorado -
University of Virginia -
University of Wisconsin School of Medicine and Public Health
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