Professor, Psychiatry, Neurology, Pediatrics and Pathology, University Massachusetts Medical School
Neurology
Dr. Edward I. Ginns, MD
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Edward Ginns practices Neurology. He attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a one of the best medicals schools. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. Edward Ginns is also published. He has 101 publications published. The lastest publication: "Monitoring the CNS pathology in aspartylglucosaminuria mice.'
Publications
- Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.
- Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.
- Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes.
- Skin ultrastructural findings in type 2 Gaucher disease: Diagnostic implications.
- Therapy for Gaucher disease: don't stop thinking about tomorrow.
- DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict reward.
- Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype.
- Effect of ethacrynic acid on the sodium- and potassium-activated adenosine triphosphatase activity and expression in Old Order Amish bipolar individuals.
- Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia.
- Joint multi-population analysis for genetic linkage of bipolar disorder or "wellness" to chromosome 4p.
- GM1 ganglioside concentration in the cerebrospinal fluid of hydrocephalic infants and children.
- Cells isolated from trypsin-treated brain contain trypsin.
- Trypsin bound to sephadex beads. A tool for neuronal cell dissociation.
- Neuron-specific enolase and its mRNA are highly expressed in large congenital nevi: a study using immunocytochemistry, biochemical assay, and in situ hybridization.
- A radioassay for GM1 ganglioside concentration in cerebrospinal fluid.
- Glutamic acid decarboxylase mRNA in rat brain: regional distribution and effects of intrastriatal kainic acid.
- Linkage between the loci for autosomal dominant Charcot-Marie-Tooth neuropathy type 1 and human glucocerebrosidase.
- GM1 ganglioside concentration in the cerebrospinal fluid of neonates and children.
- Detection of polyglutamine expansion in a new acidic protein: a candidate for childhood onset schizophrenia?
- Targeted reduction of oxytocin expression provides insights into its physiological roles.
- Monitoring the CNS pathology in aspartylglucosaminuria mice.
- A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.
- The characterization and sequence analysis of thirty CTG-repeat containing genomic cosmid clones.
- Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses.
- Large CAG/CTG repeats are associated with childhood-onset schizophrenia.
- Association of an X-chromosome dodecamer insertional variant allele with mental retardation.
- Oxytocin and milk removal are required for post-partum mammary-gland development.
- HLA antigens in childhood onset schizophrenia.
- A triplet repeat on 17q accounts for most expansions detected by the repeat-expansion-detection technique.
- Splenectomy in Gaucher disease: new management dilemmas.
- Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and "multidimensionally impaired".
- Gaucher''s disease: the best laid schemes of mice and men.
- Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, an...
- Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients.
- Gaucher disease plus.
- Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.
- The inheritance of bipolar affective disorder: abundant genes coming together.
- Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition.
- Epidermal abnormalities may distinguish type 2 from type 1 and type 3 of Gaucher disease.
- Genotype D399N/R463C in a patient with type 3 Gaucher disease previously assigned genotype N370S/R463C.
- Structure and organization of the human metaxin gene (MTX) and pseudogene.
- A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish.
- A biochemical and immunocytochemical study on the targeting of alglucerase in murine liver.
- Treatment of Gaucher's disease.
- Clinical heterogeneity among patients with Gaucher's disease.
- Isolation, characterization, and proteolysis of human prosaposin, the precursor of saposins (sphingolipid activator proteins).
- A novel transcript from a pseudogene for human glucocerebrosidase in non-Gaucher disease cells.
- Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease.
- DNA mutational analysis of type 1 and type 3 Gaucher patients: how well do mutations predict phenotype?
- Pathologic fractures may develop in Gaucher patients receiving enzyme replacement therapy.
- False-positive pregnancy tests in Gaucher''s disease.
- Direct sequencing of trinucleotide repeats from cosmid genomic DNA template.
- Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease.
- Genetic basis of Gaucher disease.
- Structure and organization of the human thrombospondin 3 gene (THBS3).
- Diagnosing Gaucher disease. Early recognition, implications for treatment, and genetic counseling.
- A new group of glucocerebrosidase isozymes found in human white blood cells.
- Isolation of cDNA clones for human beta-glucocerebrosidase using the lambda gt11 expression system.
- The occurrence of two immunologically distinguishable beta-glucocerebrosidases in human spleen.
- Biosynthesis of the lysosomal enzyme glucocerebrosidase.
- Gene mapping and leader polypeptide sequence of human glucocerebrosidase: implications for Gaucher disease.
- Ultrastructural localization of glucocerebrosidase in cultured Gaucher''s disease fibroblasts by immunocytochemistry.
- Retrovirus-mediated transfer of the human glucocerebrosidase gene to Gaucher fibroblasts.
- Localization of neuron-specific enolase (NSE) mRNA in human brain.
- Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
- Bone marrow transplantation in Gaucher disease.
- The molecular biology of Gaucher disease and the potential for gene therapy.
- Genetic heterogeneity in type 1 Gaucher disease: multiple genotypes in Ashkenazic and non-Ashkenazic individuals.
- Glucocerebrosidase, a lysosomal enzyme that does not undergo oligosaccharide phosphorylation.
- Glycosylation and processing of high levels of active human glucocerebrosidase in invertebrate cells using a baculovirus expression vector.
- Signal sequence and DNA-mediated expression of human lysosomal alpha-galactosidase A.
- CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide.
- Nucleotide sequence of cDNA containing the complete coding sequence for human lysosomal glucocerebrosidase.
- The subcellular localization of soluble and membrane-bound lysosomal enzymes in I-cell fibroblasts: a comparative immunocytochemical study.
- Human tyrosine hydroxylase (TH) genomic fragment (pHGTH4) identifies a PstI polymorphism.
- Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector.
- Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs.
- A mutation in the human glucocerebrosidase gene in neuronopathic Gaucher's disease.
- Regional distribution of the GABAA/benzodiazepine receptor (alpha subunit) mRNA in rat brain.
- Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.
- Gaucher's disease: advances and challenges.
- Microinjection into Xenopus oocytes: equipment.
- Brain grafts and Parkinson's disease.
- Production of antisera selective for m1 muscarinic receptors using fusion proteins: distribution of m1 receptors in rat brain.
- Genetically altered and defined cell lines for transplantation in animal models of Parkinson''s disease.
- Mutations in Gaucher''s disease detected by MspI.
- gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture.
- Anemic Gaucher patients with elevated endogenous erythropoietin levels may not respond to recombinant erythropoietin therapy.
- Prolonged ethanol inhalation decreases gamma-aminobutyric acidA receptor alpha subunit mRNAs in the rat cerebral cortex.
- Linkage analysis of juvenile parkinsonism to tyrosine hydroxylase gene locus on chromosome 11.
- Gaucher patients with oculomotor abnormalities do not have a unique genotype.
- Erythropoietin levels in Gaucher patients.
- DNA mutation analysis of Gaucher patients.
- Gaucher disease in the neonate: a distinct Gaucher phenotype is analogous to a mouse model created by targeted disruption of the glucocerebrosidase gene.
- Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.
- Responses of the mouse to microwave radiation during estrous cycle and pregnancy.
- Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish.
- Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21.
- Human glucocerebrosidase: heterologous expression of active site mutants in murine null cells.
- Cardiovascular fibrosis, hydrocephalus, ophthalmoplegia, and visceral involvement in an American child with Gaucher disease.
Schools
Johns Hopkins University School of Medicine
Baltimore City Hospital
Albert Einstein College Med
Rensselaer
Johns Hopkins School Med
Doctors Specialties
- Neurology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
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Albert Einstein College of Medicine at Jacobi Medical Center -
Johns Hopkins University School of Medicine
Hospital
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UMass Memorial Medical Center
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