Hastings Professor and Norris Chair, Department of Medicine, University of Southern California
Pulmonology
Dr. Edward D. Crandall, MD
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Edward Crandall is an expert in the field of Pulmonology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He received awards:"Elected Member" and "Super Doctor". Edward Crandall is also a published physician. He has 101 paper published. The most recent paper is: Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane.
Publications
- A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
- Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
- Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers.
- Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano Go Consortium.
- Nanoparticle translocation across mouse alveolar epithelial cell monolayers: Species-specific mechanisms.
- Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism.
- ?-CATENIN/CBP-DEPENDENT REGULATION OF TGF-?-MEDIATED EPITHELIAL-MESENCHYMAL TRANSITION (EMT) BY SMAD3.
- Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition.
- Polystyrene nanoparticle trafficking across MDCK-II.
- Role of ER Stress in EMT of Alveolar Epithelial Cells: Effects of Misfolded Surfactant Protein.
- Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure.
- Directed expression of Cre in alveolar epithelial type 1 cells.
- Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles.
- More life for a "terminal" cell.
- Characterization of mouse alveolar epithelial cell monolayers.
- Conjugation with cationic cell-penetrating peptide increases Pulmonary absorption of insulin.
- GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.
- Retention of human bone marrow-derived cells in murine Lungs following bleomycin-induced Lung injury.
- Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and Lung in vivo.
- Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.
- Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
- Polystyrene nanoparticle trafficking across alveolar epithelium.
- Expression and biological activity of ABCA1 in alveolar epithelial cells.
- Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
- Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling.
- Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s).
- Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers.
- Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha.
- SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells.
- Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic Pulmonary fibrosis.
- Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers.
- Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells.
- Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers.
- Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2.
- Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer.
- The critical care crisis in the United States: a report from the profession.
- Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers.
- Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers.
- Identification of three genes of known function expressed by alveolar epithelial type I cells.
- Absorption of intact albumin across rat alveolar epithelial cell monolayers.
- Historical perspectives on Lung edema clearance.
- Na transport proteins are expressed by rat alveolar epithelial type I cells.
- Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers.
- Polarity of alveolar epithelial cell acid-base permeability.
- Bicarbonate-chloride exchange in erythrocyte suspensions. Stopped-flow pH electrode measurements.
- Hydroxyl ion movements across the human erythrocyte membrane. Measurement of rapid pH changes in red cell suspensions.
- Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane.
- Effects of salicylate on HCO-3/Cl- exchange across the human erythrocyte membrane.
- Effects of inhibition of RBC HCO3-/Cl- exchange on CO2 excretion and downstream pH disequilibrium in isolated rat Lungs.
- Analysis of the effects of hematocrit on Pulmonary CO2 transfer.
- Pulmonary vascular carbonic anhydrase activity.
- Organ and species differences in tissue vascular carbonic anhydrase activity.
- Time course of exchanges between red cells and extracellular fluid during CO2 uptake.
- Postcapillary pH disequilibrium after gas exchange in isolated perfused liver.
- Slow postcapillary changes in blood pH in vivo: titration with acetazolamide.
- A pressure- and flow-insensitive reference electrode liquid junction.
- Analysis of postcapillary pH changes in blood in vivo after gas exchange.
- Pulmonarygas exchange.
- NHLBI workshop summary. Workshop on techniques to evaluate Lung alveolar-microvascular injury.
- Effects of red blood cell HCO3(-)/Cl- exchange kinetics on Lung CO2 transfer: theory.
- Effects of dextran-bound inhibitors on carbonic anhydrase activity in isolated rat Lungs.
- Kinetic analysis of calcium transport across the placenta.
- Postcapillary changes in blood pH in vivo during carbonic anhydrase inhibition.
- Slow postcapillary pH changes in blood in anesthetized animals.
- Analysis of PCO2 differences during rebreathing due to slow pH equilibration in blood.
- Type II alveolar epithelial cells in suspension: separation by density and velocity.
- Water and nonelectrolyte transport across alveolar epithelium.
- Dome formation in primary cultured monolayers of alveolar epithelial cells.
- Effects of terbutaline on sodium transport in isolated perfused rat Lung.
- Effects of exposure to NO2 on dome formation in alveolar epithelial cell monolayers.
- Characterization of Na+-H+ antiport in type II alveolar epithelial cells.
- Transport of water and solutes across sheep visceral pleura.
- Recent developments in Pulmonary edema.
- Type I cell-like morphology in tight alveolar epithelial monolayers.
- Evidence for active Na+ transport by cultured monolayers of Pulmonary alveolar epithelial cells.
- Measurement of solute fluxes in isolated rat Lungs.
- Effects of culture conditions on susceptibility of alveolar epithelial cell monolayers to NO2.
- Effects of nitrogen dioxide on alveolar epithelial barrier properties.
- Heteropore populations of bullfrog alveolar epithelium.
- Regulation of transport across Pulmonary alveolar epithelial cell monolayers.
- Cl-/HCO3- exchange modulates intracellular pH in rat type II alveolar epithelial cells.
- Defined medium for primary culture de novo of adult rat alveolar epithelial cells.
- Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels.
- Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels.
- Evidence for amiloride-sensitive sodium channels in alveolar epithelial cells.
- Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro.
- Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells.
- Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells.
- Differential regulation of rat aquaporin-5 promoter/enhancer activities in Lung and salivary epithelial cells.
- Alveolar epithelial transport. Basic science to clinical medicine.
- Transport of water and solutes across bullfrog alveolar epithelium.
- Asymmetric [14C]albumin transport across bullfrog alveolar epithelium.
- Effects of cell swelling on fluid flow across alveolar epithelium.
- Effects of Lung inflation on alveolar epithelial solute and water transport properties.
- Models for investigation of peptide and protein transport across cultured mammalian Respiratory epithelial barriers.
- Effects of exposure to acid on alveolar epithelial water and solute transport.
- Effects of Mycobacterium tuberculosis on the bioelectric properties of the alveolar epithelium.
- Sodium-amino acid cotransport by type II alveolar epithelial cells.
- Protein traffic across Lung epithelia.
- NO2 decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers.
Schools
University Of Pennsylvania School Of Medicine
Hospital Penn
Procedures Preformed
- Bronchoscopy
- Continuous Positive Airway Pressure (CPAP)
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Alkalosis
- Asthma
- Atelectasis
- View All
Doctors Specialties
- Pulmonology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Select PPO
- Access Plus Savenet
- Basic Exclusive PPO for Small Business
- Basic PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Covered California - Bronze PPO
- Health Net PPO
- Individual and Family PPO
- Medicare Advantage PFFS
- Medicare MCR
- Kaiser PHCS Network PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
- Super Doctor
Education
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University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Keck Hospital of USC
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