Physician
Rheumatology
Dr. Dwight H. Kono, MD
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Dr. Dwight H. Kono practices Rheumatology. He received 2 awards: "Fellow (FACR)" and "Fellow". Dwight Kono is a published doctor. He has 100 papers published. The most current publication "Mechanisms and genetics of autoimmunity."
Publications
- The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus.
- Requirements for fire and ICE differ between animal models of autoimmunity: comment on the article by Kahlenberg et al.
- TLRs and interferons: a central paradigm in autoimmunity.
- Interferon-gamma and Systemic Autoimmunity.
- Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.
- Role of Nucleic Acid-Sensing TLRs in Diverse Autoantibody Specificities and Anti-nuclear Antibody-Producing B Cells.
- Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.
- Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice.
- Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.
- Intracellular Nucleic Acid Sensors and Autoimmunity.
- Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7R? Blockade.
- Mast cell function is not altered by Coronin-1A deficiency.
- Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.
- Toxicology of autoimmune diseases.
- Sensors of the innate immune system: their link to rheumatic diseases.
- Sensors of the innate immune system: their mode of action.
- Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.
- Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis.
- ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
- ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.
- The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
- Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3.
- TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.
- Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.
- Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice.
- Type I interferons (alpha/beta) in immunity and autoimmunity.
- Costimulation requirements of induced murine systemic autoimmune disease.
- Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice.
- Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity.
- Genetic complementation in female (BXSB x NZW)F2 mice.
- Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity.
- Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice.
- Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages.
- Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice.
- A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity.
- Requirements for innate immune pathways in environmentally induced autoimmunity.
- Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.
- The T-cell receptor repertoire and autoimmune diseases.
- Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy.
- Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.
- A Yersinia pseudotuberculosis protein which cross-reacts with HLA-B27.
- A heat-modifiable outer membrane protein carries an antigen specific for the species Yersinia enterocolitica and Yersinia pseudotuberculosis.
- Successful IV pulse cyclophosphamide in refractory PM in 3 patients with SLE.
- Genomically imposed and somatically modified human thymocyte V beta gene repertoires.
- Complexity and sequence identification of 24 rat V beta genes.
- A ribosomal protein of Yersinia pseudotuberculosis having partial epitope identity with HLA-B27.
- Identification of encephalitogenic V beta-4-bearing T cells in SJL mice. Further evidence for the V region disease hypothesis?
- New human V beta genes and polymorphic variants.
- Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome.
- Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.
- Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.
- V beta repertoire in rats and implications for endogenous superantigens.
- An animal model to study serum immunoglobulin response to infection by Yersinia enterocolitica.
- Rabbit antisera against three different bacteria which can induce reactive arthritis: analysis by ELISA, immunoprecipitation and Western Blot.
- Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria.
- Study of Reiter''s syndrome, with special emphasis on Yersinia enterocolitica.
- Experimental animal models of Yersinia infection and Yersinia-induced arthritis.
- Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella pneumoniae.
- B and T cell antigen receptor repertoires in lupus/arthritis murine models.
- High degree of conservation between ribosomal proteins of Yersinia pseudotuberculosis and Escherichia coli.
- A Yersinia enterocolitica serotype 0:3 lipopolysaccharide-specific monoclonal antibody reacts more strongly with bacteria cultured at room temperature than those cultu...
- Autoimmune disease and T-cell immunologic recognition.
- T-cell receptor genes in autoimmunity.
- T cell receptor V beta 15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines.
- V beta repertoire of murine hepatic T cells. Implication for selection of double negative alpha beta + T cells.
- Lupus susceptibility loci in New Zealand mice.
- Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupu...
- T-cell repertoires in health and disease.
- Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.
- Human T helper cells specific for HIV reverse transcriptase: possible role in intrastructural help for HIV envelope-specific antibodies.
- Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen.
- Genetics of systemic autoimmunity and glomerulonephritis in mouse models of lupus.
- Role of cyclin kinase inhibitor p21 in systemic autoimmunity.
- Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice.
- Resistance to xenobiotic-induced autoimmunity maps to chromosome 1.
- The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus.
- T cell homeostasis and systemic autoimmunity.
- The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity.
- Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice.
- Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.
- Genetics of systemic autoimmunity in mouse models of lupus.
- The pathogenesis of autoimmunity in New Zealand mice.
- Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc.
- Genetic studies in systemic autoimmunity and aging.
- Development of lupus in BXSB mice is independent of IL-4.
- Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity.
- The genes of systemic autoimmunity.
- Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection.
- Mechanisms and genetics of autoimmunity.
- The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance.
- Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice.
- Tgfbr1 maps to chromosome 4.
- Expression of protein-tyrosine phosphatases in the major insulin target tissues.
- G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice.
- Induction of the early growth response (Egr) family of transcription factors during thymic selection.
- Genetic contributions to SLE.
- Jak3 maps to chromosome 8.
- T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis.
- Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model.
Schools
University of Washington
Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- Fellow (FACR)
- Fellow
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