Professor of Medicine, University Tex SW Dallas
Gastroenterology
Dr. Dwain L. Thiele, MD
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Dwain L. Thiele works in the field of Gastroenterology. He studied medicine at Baylor College of Medicine. He received 3 awards: "Regional Top Doctor", "CMS Meaningful Use Stage 1 Certification" and "Elected Member". Dwain Thiele has written publications. He has 83 publications published with PubMed. The lastest publication is: 'Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells.' He accepts all Medicare patients.
Publications
- The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity.
- Tumor necrosis factor receptor 1 expression is upregulated in dendritic cells in patients with chronic HCV who respond to therapy.
- Granzyme C supports efficient CTL-mediated killing late in primary alloImmune responses.
- Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 (Serpinb9...
- The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity.
- Is anti-TNF therapy safe in patients with rheumatic Disease who also have concurrent B or C chronic hepatitis?
- Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection.
- Antiviral cytokines induce hepatic expression of the granzyme B inhibitors, proteinase inhibitor 9 and serine proteinase inhibitor 6.
- Ethnic differences in the prevalence of cryptogenic Cirrhosis.
- The role of TNF-TNFR2 interactions in generation of CTL Responses and clearance of hepatic adenovirus infection.
- TNF enhances CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host Disease by IL-12-independent mechanisms.
- Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
- TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host Disease in MHC class II-disparate (C57BL/6J-->C57BL/6J x bm12)F1 mice.
- Studies of connective tissue mast cell-mediated cytotoxicity.
- Evaluation of the polymerase chain reaction (PCR) for detection of Chlamydia psittaci in abortion material from ewes.
- Sporadic chronic non-A, non-B viral Hepatitis: a more ominous diagnosis than first surmised?
- Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucin...
- Mononuclear phagocytes: phenotype and function.
- The effect of various contexts of stress on the mouse spleen lymphocytes and macrophage co-stimulatory activity.
- Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.
- Implications of anti-Hepatitis C reactivity in 'autoimmune' chronic active Hepatitis.
- Secretory diarrhea in mixed connective tissue Disease.
- Regulation of human natural killer (NK) cell function: induction of killing of an NK-resistant renal carcinoma cell line.
- Fatal labetalol-induced hepatic injury.
- The accessory function of phagocytic cells in human T cell and B cell Responses.
- Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell Responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic...
- The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes.
- Leu-Leu-OMe sensitivity of human activated killer cells: delineation of a distinct class of cytotoxic T lymphocytes capable of lysing tumor targets.
- Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).
- Stimulus-dependent modulation of human B cell function by T cell clones.
- Tumor cell lysis by T cells distinct from NK cells and alloantigen-specific cytotoxic T cells.
- Apoptosis is induced in cells with cytolytic potential by L-leucyl-L-leucine methyl ester.
- Ex vivo purging of allogeneic marrow with L-Leucyl-L-leucine methyl ester. A phase I study.
- Pretreatment of murine donor grafts with L-leucyl-L-leucine methyl ester: elimination of graft-versus-host Disease without detrimental effects on engraftment.
- Prevention of lethal murine graft versus host Disease by treatment of donor cells with L-leucyl-L-leucine methyl ester.
- The role of leucyl-leucine methyl ester-sensitive cytotoxic cells in skin allograft rejection.
- Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
- Hepatic injury due to troglitazone.
- Active beta-endorphin metabolites generated by T-cell ectopeptidases.
- Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.
- Lethal graft-vs-host Disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells.
- Tumor necrosis factor, the acute phase response and the pathogenesis of alcoholic liver Disease.
- Enhancement of human natural killer cell function by the combined effects of tumor necrosis factor alpha or interleukin-1 and interferon-alpha or interleukin-2.
- Mechanisms of autoimmune liver Disease.
- Major histocompatibility complex-unrestricted cytolytic activity of human T cells. Analysis of precursor frequency and effector phenotype.
- Purification and characterization of dipeptidyl peptidase I from human spleen.
- Phenotypic and functional characterization of human T cell clones.
- Cellular blebbing in superficial colonic epithelial cells occurring with murine graft-versus-host Disease.
- Histologic similarity of murine colonic graft-versus-host Disease (GVHD) to human colonic GVHD and inflammatory bowel Disease.
- Analysis of the functional capabilities of CD3+CD4-CD8- and CD3+CD4+CD8+ human T cell clones.
- The impact of major histocompatibility complex (MHC) and non-MHC antigenic differences on graft-versus-host Disease mediated by helper T cells.
- Liver injury associated with Hepatitis C infection: is it the virus or is it the host?
- Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.
- The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase ...
- Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells.
- Intestinal graft-versus-host Disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes.
- Acute sporadic non-A, non-B, non-C, non-D, non-D, non-E Hepatitis.
- Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium.
- Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE).
- Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C).
- Increased expression of an endopeptidase (gamma-EGE/IDE) hydrolyzing beta-endorphin during differentiation and maturation of bone marrow macrophages.
- Virally infected hepatocytes are resistant to perforin-dependent CTL effector mechanisms.
- Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host Disease.
- A secreted peptidase involved in T cell beta-endorphin metabolism.
- Anti-CD3 and phorbol myristate acetate regulation of MHC unrestricted T cell cytotoxicity. Lack of a requirement for CD3/T cell receptor complex expression during tumo...
- Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enric...
- A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8+ T cell cytotoxic effector function.
- Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens.
- Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation.
- The role of major histocompatibility complex and non-major histocompatibility complex encoded antigens in generation of bile duct lesions during hepatic graft-vs.-host...
- Reactivity of hybridomas derived from T cells activated in vivo during graft-versus-host Disease.
- IL-1 beta convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms.
- Lethal graft-vs-host Disease induced by a class II MHC antigen only disparity is not mediated by cytotoxic T cells.
- Protection from T helper cell-mediated graft-versus-host Disease by the presence of an MHC class I alloantigen is associated with perturbation of MHC class II-restrict...
- Enhancement of MHC class I-stimulated alloResponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloResponses by TNF/TNFR2 interactions.
- T-cell activation and differentiation are regulated by TNF during murine DBA/2-->B6D2F1 intestinal graft-versus-host Disease.
- Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells.
- Steroid therapy of chronic Hepatitis: characteristics associated with response in anti-Hepatitis C virus-positive and -negative patients.
- CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes.
- Dipeptidyl peptidase I is enriched in granules of in vitro- and in vivo-activated cytotoxic T lymphocytes.
- Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell Responses.
- Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral Hepatitis in mice.
Schools
Baylor Coll Of Med
Duke Mc
University Tx Sw
The University of Texas Southwestern Medical Center Senior Associate Dean for Strategic Development
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
- Liver Biopsy
Conditions Treated
- Abdominal Pain
- Anemia
- Biliary Atresia
- Cholecystitis and Gallstones
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Regional Top Doctor
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
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Duke University Hospital -
Baylor College of Medicine
Hospital
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University of Texas Southwestern Medical Center -
Parkland Health & Hospital System
Drug Facts
| NPI NUMBER | 1730145152 | |
| NPPES Provider LastName | THIELE | |
| NPPES Provider FirstName | DWAIN | |
| NPPES Provider ZIPCode | 753907208 | |
| NPPES Provider State | TX | |
| Specialty Description | Gastroenterology | |
| Total Claim Count | 184.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1730145152 |
| Last Name Of The Provider | THIELE |
| First Name Of The Provider | DWAIN |
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