Physician
Infectious Disease
Dr. Douglas T. Golenbock, MD
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Douglas Golenbock is an expert in the field of Infectious Disease. He went to University of Michigan Medical School. He received awards:"Elected Member". Doctor Douglas T. Golenbock, MD has written publications. He has 102 publications published with PubMed. The lastest publication is: 'A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.'
Publications
- LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.
- Innate immunity in Alzheimer's disease.
- Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
- Innate sensing of malaria parasites.
- Hemolysis-induced lethality involves inflammasome activation by heme.
- The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria.
- HMG-CoA reductase inhibitors (statins)-induced 28-kDa interleukin-1β interferes with mature IL-1β signaling.
- TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching.
- Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
- Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
- Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria.
- CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
- Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.
- The Abi-domain Protein Abx1 Interacts with the CovS Histidine Kinase to Control Virulence Gene Expression in Group B Streptococcus.
- Inflammation in Mice Ectopically Expressing Human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T Mutant Proteins.
- Dried whole plant Artemisia annua as an antimalarial therapy.
- UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
- Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice.
- Toll-like Receptor (TLR) 2 Mediates Inflammatory Responses to Oligomerized RrgA Pneumococcal Pilus Type 1 Protein.
- Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research.
- Activation of the NLRP3 Inflammasome by Group B Streptococci.
- NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA.
- Genome-Wide Expression Profiling and Mutagenesis Studies Reveal That Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression a...
- Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome.
- Requirement of UNC93B1 Reveals a Critical Role for TLR7 in Host Resistance to Primary Infection with Trypanosoma cruzi.
- Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
- Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
- Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
- Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related ada...
- MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
- MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
- TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
- UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
- Inflammasomes: too big to miss.
- Innate immune recognition of Yersinia pseudotuberculosis type III secretion.
- Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
- A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
- MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
- MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
- Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
- Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
- Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
- TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
- TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
- The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
- Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
- Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
- Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
- Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.
- MUC1 mucin is a negative regulator of toll-like receptor signaling.
- Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
- The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14.
- Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
- Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.
- Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
- Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
- Immunology. The shape of things to come.
- Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
- Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, o...
- Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
- MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
- Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
- TLR9 and the recognition of self and non-self nucleic acids.
- HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
- A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
- Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
- The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
- Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.
- c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis.
- Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
- Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
- Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
- Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells.
- The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
- Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
- A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
- Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
- Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
- Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
- The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
- Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
- Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
- Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
- The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
- Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
- Innate immune responses to Rhodococcus equi.
- Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
- Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
- Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
- Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
- Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requi...
- TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
- IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
- Phagocytosis, innate immunity, and host-pathogen specificity.
- Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
- Adjuvants and their signaling pathways: beyond TLRs.
- Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
- LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
- A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
Schools
University of Mi Med Sch
George Washington University Med Center
University Wisc Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
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University of Wisconsin -
George Washington University -
University of Michigan Medical School
Hospital
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UMass Memorial Medical Center
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