Professor, Pathology and Immunology, Washington University School of Medicine
Pathology
Dr. Douglas M. Lublin, MD
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Douglas Lublin is an expert in the field of Pathology. He researched medicine at David Geffen School of Medicine at UCLA. David Geffen School of Medicine at UCLA is a top medical university. David Geffen School of Medicine at UCLA is ranked 13/7 in Research/PrimaryCare. Doctor Douglas M. Lublin, MD is also a published doctor. He has 94 paper published. The most recent paper is: Expression and functional analysis of glycosyl-phosphatidyl inositol-linked CD46 in transgenic mice.
Publications
- The efficacy of photopheresis for bronchiolitis obliterans syndrome after lung transplantation.
- A review of transfusion risks and optimal management of perioperative bleeding with cardiac surgery.
- Three new high-prevalence antigens in the Cromer blood group system.
- Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic ...
- Transfusion risks and transfusion-related pro-inflammatory responses.
- B-type natriuretic peptide measured during transfusion-related acute lung injury.
- The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation.
- Heparin low . . . photo no!
- In-house validation of the BACTEC 9240 blood culture system for detection of bacterial contamination in platelet concentrates.
- Conformational defects slow Golgi exit, block oligomerization, and reduce raft affinity of caveolin-1 mutant proteins.
- Transfusion medicine service policies for recombinant factor VIIa administration.
- Non-ischemic left ventricular dysfunction after pediatric cardiac transplantation: treatment with plasmapheresis and OKT3.
- Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets.
- Collection of a mobilized peripheral blood apheresis product from a patient with mucopolysaccharidosis type VII and subsequent CD34+ cell isolation.
- Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1.
- Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia.
- GUTI: a new antigen in the Cromer blood group system.
- Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I.
- Molecular mapping of the Cromer blood group Cra and Tca epitopes of decay accelerating factor: toward the use of recombinant antigens in immunohematology.
- Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes.
- Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.
- Characterization of DAF-2, a high molecular weight form of decay-accelerating factor (DAF; CD55), as a covalently cross-linked dimer of DAF-1.
- Short consensus repeat-3 domain of recombinant decay-accelerating factor is recognized by Escherichia coli recombinant Dr adhesin in a model of a cell-cell interaction.
- Mechanism of enhanced complement-dependent cytotoxicity of papain-treated lymphocytes: evidence for increased stability of classical pathway C3 convertase.
- Mechanisms of the CYNAP phenomenon: evidence in the Bw49/Bw50 model for epitopes with different spatial orientation of antibody.
- A polymorphism of the complement regulatory protein MCP (membrane cofactor protein or gp45-70).
- Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.
- Human genes for three complement components that regulate the activation of C3 are tightly linked.
- The polymorphism of the C3b/C4b receptor in the normal population and in patients with systemic lupus erythematosus.
- Influence of glycosylation on allelic and cell-specific Mr variation, receptor processing, and ligand binding of the human complement C3b/C4b receptor.
- Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.
- Decay-accelerating factor: biochemistry, molecular biology, and function.
- Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.
- The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.
- Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.
- Biosynthesis and glycosylation of the human complement regulatory protein decay-accelerating factor.
- The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46.
- Polymorphisms of the regulators of complement activation gene cluster.
- Expression of a liver fatty acid binding protein/human decay-accelerating factor/HLA-B44 chimeric gene in transgenic mice.
- Phospholipid-anchored and transmembrane versions of either decay-accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-m...
- Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants.
- Decay-accelerating factor and membrane cofactor protein.
- Structure of the gene for human complement protein decay accelerating factor.
- Glycosyl-phosphatidylinositol anchoring of membrane proteins.
- Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1.
- Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor.
- Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia ...
- Terminology for blood group antigens and genes-historical origins and guidelines in the new millennium.
- Molecular basis of Cromer blood group antigens.
- Role of decay-accelerating factor domains and anchorage in internalization of Dr-fimbriated Escherichia coli.
- The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoy...
- Expression and functional analysis of glycosyl-phosphatidyl inositol-linked CD46 in transgenic mice.
- Short consensus repeat domain 1 of decay-accelerating factor is required for enterovirus 70 binding.
- Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
- Membrane cofactor protein (CD46) is a basolateral protein that is not endocytosed. Importance of the tetrapeptide FTSL at the carboxyl terminus.
- Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H.
- Activation of the gene encoding decay accelerating factor following nerve growth factor treatment of sensory neurons is mediated by promoter sequences within 206 bases...
- Control of the complement system.
- CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.
- The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55).
- Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol.
- Blood group antigens: so many jobs to do.
- Expression of functional decay-accelerating factor (CD55) in transgenic mice protects against human complement-mediated attack.
- Construction of synthetic signals for glycosyl-phosphatidylinositol anchor attachment. Analysis of amino acid sequence requirements for anchoring.
- Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.
- Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals.
- Rh-related antigen CD47 is the signal-transducer integrin-associated protein.
- Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae.
- Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck.
- Distinct tyrosine kinase activation and Triton X-100 insolubility upon Fc gamma RII or Fc gamma RIIIB ligation in human polymorphonuclear leukocytes. Implications for ...
- Identification of 5'-flanking regions affecting the expression of the human decay accelerating factor gene and their role in tissue-specific expression.
- Characterization of the echovirus 7 receptor: domains of CD55 critical for virus binding.
- Identification of complement regulatory domains in human factor H.
- dra-related X adhesins of gestational pyelonephritis-associated Escherichia coli recognize SCR-3 and SCR-4 domains of recombinant decay-accelerating factor.
- Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46).
- SERF: a new antigen in the Cromer blood group system.
- Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transme...
- Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets.
- Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection against complement-mediated injury during...
- Universal RBCs.
- Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
- Location of WESb on decay-accelerating factor.
- Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55).
- Review: Cromer and DAF: role in health and disease.
- Autoantibody formation after alloimmunization: are blood transfusions a risk factor for autoimmune hemolytic anemia?
- Permanent expression of human CD59 and/or decay-accelerating factor by rat endothelial cells confers protection from human complement-mediated lysis.
- Efficient generation of monoclonal antibodies for specific protein domains using recombinant immunoglobulin fusion proteins: pitfalls and solutions.
- Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis.
- Protection of rat endothelial cells from primate complement-mediated lysis by expression of human CD59 and/or decay-accelerating factor.
- Prostanoid receptors in intestinal epithelium: selective expression, function, and change with inflammation.
- Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression.
- Safety concerns related to use of unapproved needles for accessing implantable venous access devices.
- Off-label use of recombinant factor VIIA concentrates after cardiac surgery.
Schools
University of California At Los Angeles
Barnes Jewish Hospital
Barnes Jewish Hospital S Campus
Brigham and Women39s Hospital
Doctors Specialties
- Pathology
Accepted Insurances
Education
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Washington University - Barnes-Jewish Hospital -
Barnes-Jewish Hospital -
David Geffen School of Medicine at UCLA -
Brigham and Women's Hospital
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