Physician
Endocrinology
Dr. Donald A. McClain, MD
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Donald A. McClain practices Endocrinology. He went to medical school at Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18 in research and 49 in primary care medicine He over the years received 1 awards: "Elected Member". Donald McClain is a published physician as well. He has 103 publications published. The latest was: Regulation of glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase.
Publications
- Metabolic aspects of high-altitude adaptation in Tibetans.
- Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.
- Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae).
- Dietary Iron Controls Circadian Hepatic Glucose Metabolism through Heme Synthesis.
- Skeletal muscle ras-related GTP binding B mRNA and protein expression is increased after essential amino Acid ingestion in healthy humans.
- A genetic mechanism for Tibetan high-altitude adaptation.
- Anti-obesity and pro-Diabetic effects of hemochromatosis.
- Diabetes and hemochromatosis.
- Downregulation of E3 Ubiquitin Ligases and Mitophagy-Related Genes in Skeletal Muscle of Physically Inactive, Frail Older Women: A Cross-Sectional Comparison.
- Regulation of fatty acid Metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.
- Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.
- Iron and Diabetes risk.
- Manganese Supplementation Protects Against Diet-Induced Diabetes in Wild Type Mice by Enhancing Insulin Secretion.
- Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose Metabolism.
- The Utah Center for Clinical and Translational Science: transformation through collaboration.
- Systemic PPARγ Deletion Impairs Circadian Rhythms of Behavior and Metabolism.
- Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin s...
- Regional muscle glucose uptake remains elevated 1 week after cessation of resistance training independent of altered insulin sensitivity response in older adults With ...
- Genetic determinants of Tibetan high-altitude adaptation.
- Pleiotropic and age-dependent effects of decreased protein modification by o-linked n-acetyl glucosamine on pancreatic {beta}-cell function and vascularization.
- Iron overload and Diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.
- Dietary iron restriction or iron chelation protects from Diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.
- Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis.
- Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
- Up-regulation of O-GlcNAc transferase With glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.
- Increased strength and physical performance With eccentric training in women With impaired glucose tolerance: a pilot study.
- Regulation of Akt signaling by O-GlcNAc in euglycemia.
- Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells.
- Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
- Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.
- Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis.
- A role for the transcriptional coactivator PGC-1alpha in muscle refueling.
- PAS kinase is required for normal cellular energy balance.
- Utility of ultrasound-guided fine-needle aspiration of Parathyroid adenomas for localization before minimally invasive Parathyroidectomy.
- Recipes for creating animal models of Diabetic cardiovascular disease.
- Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes.
- Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.
- Adipocytes With increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid.
- Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and re...
- Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.
- Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
- Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.
- Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.
- Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance.
- Insulin signaling coordinately regulates cardiac size, Metabolism, and contractile protein isoform expression.
- Hexosamines as mediators of nutrient sensing and regulation in Diabetes.
- Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.
- Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl fatty acid, phenyl acetate: chemoprevention by targeting the p21RAS prot...
- Modulation of lymphocyte mitogenesis.
- Assay for early cytoplasmic effects of the src gene product of Rous sarcoma virus.
- Role of surface modulating assemblies in growth control of normal and transformed fibroblasts.
- A neural cell adhesion molecule from human brain.
- Chimeric receptors expressing juxtamembrane sequences of the insulin receptor undergo rapid endocytosis in the absence of receptor tyrosine kinase activity.
- The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts.
- Effects of insulin and insulin-like growth factor I on growth of human leukemia cells in serum-free and protein-free medium.
- Analysis of hepatic glycogen-associated proteins.
- Density-dependent stimulation and inhibition of cell growth by agents that disrupt microtubules.
- Insulin receptor kinase activation releases a constraint maintaining the receptor on microvilli.
- Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.
- Neural cell adhesion molecules in rodent brains isolated by monoclonal antibodies With cross-species reactivity.
- Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.
- A mutant insulin receptor With defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
- A domain of the insulin receptor required for endocytosis in rat fibroblasts.
- Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells.
- Properties of a human insulin receptor With a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.
- Characterization of an insulin receptor mutant lacking the subunit processing site.
- Further insights into leptin action.
- Insulin action in cells expressing truncated or kinase-defective insulin receptors. Dissection of multiple hormone-signaling pathways.
- Effects of glucosamine infusion on insulin secretion and insulin action in humans.
- Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts.
- Insulin-receptor cDNA sequence in NIDDM patient homozygous for insulin-receptor gene RFLP.
- UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
- Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 ...
- Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway.
- Endocytosis of insulin receptors is not required for activation or deactivation of the hormone response.
- Augmented mitogenesis and impaired metabolic signaling mediated by a truncated insulin receptor.
- Properties of a human insulin receptor With a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic ef...
- Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors.
- Insulin receptors With defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.
- Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.
- Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors.
- Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
- Restriction-fragment-length polymorphism in insulin-receptor gene and insulin resistance in NIDDM.
- Glucosamine regulation of glucose Metabolism in cultured human skeletal muscle cells: divergent effects on glucose transport/phosphorylation and glycogen synthase in n...
- Hexosamines and insulin resistance.
- Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts.
- Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway.
- Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients With NIDDM.
- Regulation of glycogen synthase and protein phosphatase-1 by hexosamines.
- Hexosamines regulate leptin production in human subcutaneous adipocytes.
- The role of mPer2 clock gene in glucocorticoid and feeding rhythms.
- Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues.
- Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
- Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-depe...
- Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.
- Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13.
- Regulation of glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase.
- Regulation of glycogen synthase by glucose, glucosamine, and glutamine:fructose-6-phosphate amidotransferase.
- Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia.
- Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine.
- Synergistic inhibitory effects of hypoxia and iron deficiency on hepatic glucose response in mouse liver.
- Local release of masitinib alters in vivo implantable continuous glucose sensor performance.
Schools
Joan Sanford I Weill Medical College Of Cornell University
Stanford University Med Center
Conditions Treated
- Calcium Metabolism Disorders
- Diabetes Type 1
- Diabetes Type 2
- Diabetes With Renal Manifestations
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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University of California San Diego -
Stanford University -
Weill Cornell Medical College of Cornell University
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