Physician
Obstetrics & Gynecology
Dr. Don R. Phillips, MD
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Phillips practices Obstetrics & Gynecology. He went to medical school at University of Arkansas for Medical Sciences. University of Arkansas for Medical Sciences is ranked 83 in research and 35 in primary care medicine He received 2 awards: "CMS Meaningful Use Stage 1 Certification" and "Fellow (FACOG)". Phillips is a published doctor. He published 32 publications, including: 'M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.' He accepts Medicare.
Publications
- The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs.
- M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.
- New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.
- The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects Normal cells against toxicity of anticancer agents while augmenting their anticanc...
- Detection of adriamycin-DNA adducts by accelerator mass spectrometry.
- In vitro transcription assay for resolution of drug-DNA interactions at defined DNA sequences.
- Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized antiCancer chemotherapy.
- Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.
- Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate.
- Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.
- In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in Human prostate cancer.
- The role of intracellularly released formaldehyde and butyric acid in the antiCancer activity of acyloxyalkyl esters.
- Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance.
- A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences.
- Formation of mitoxantrone adducts in Human tumor cells: potentiation by AN-9 and DNA methylation.
- Sequence specificity of adriamycin-DNA adducts in Human tumor cells.
- Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast Cancer cells.
- The direct mapping of the uptake of platinum anticancer agents in individual Human ovarian adenocarcinoma cells using a hard X-ray microprobe.
- Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in Ovarian cancer cell lines.
- Activation of adriamycin by the pH-dependent formaldehyde-releasing prodrug hexamethylenetetramine.
- Detection of labile anthracycline-DNA adducts by real-time PCR.
- DNA binding by pixantrone.
- The power and potential of doxorubicin-DNA adducts.
- DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.
- Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines.
- The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity.
- Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent.
- Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations.
- CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity.
- Formaldehyde-releasing prodrugs specifically affect Cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species.
- ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adducts.
Schools
University of Arkansas For Medical Sciences
University Ark School Med
Procedures Preformed
- C-Section
- Colpopexy
- Colporrhaphy
- Colposcopy
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Conditions Treated
- Atrophic Vaginitis
- Breech Position
- Cervical Polyps
- Cervicitis
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Doctors Specialties
- Obstetrics
- Gynecology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FACOG)
Education
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University of Arkansas for Medical Sciences -
University of Arkansas for Medical Sciences College of Medicine
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