Penn Heart and Vascular Center Perelman Center for Advanced Medicine
Cardiology
Dr. Dennis L. Sprecher, MD
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Dennis Sprecher is an expert in the field of Cardiology. He graduated from Boston University School of Medicine. Boston University School of Medicine is ranked 30/52 in Research/PrimaryCare. He received awards:"CMS Meaningful Use Stage 1 Certification". Dennis Sprecher is also a published doctor. He has 101 paper published. The most recent paper is: Association of body fat distribution and cardiovascular risk factors in children and adolescents.
Publications
- A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
- Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
- Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers.
- The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale.
- Apolipoprotein B-100-Containing Lipoprotein Metabolism in Subjects With Lipoprotein Lipase Gene Mutations.
- Mechanism of Action of a Peroxisome Proliferator-Activated Receptor (PPAR)-{delta} Agonist on Lipoprotein Metabolism in Dyslipidemic Subjects with Central Obesity.
- Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.
- Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.
- Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro.
- Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease.
- Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
- Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
- Skin cholesterol adds to Framingham risk assessment.
- Sensitivity and specificity of pediatric lipid determinations for adult lipid status: findings from the Princeton Lipid Research Clinics Prevalence Program Follow-up S...
- The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events.
- The association between fibrate use, change in high-density lipoprotein cholesterol, and the risk of cardiovascular disease: a retrospective chart review involving up ...
- Impact of nonprescriptive factors on low-density lipoprotein cholesterol reduction with statins.
- Relation of homocysteine and C-reactive protein to urinary albumin loss.
- Association between apolipoprotein E alleles and calcific valvular heart disease.
- Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome.
- Statins promote potent systemic antioxidant effects through specific inflammatory pathways.
- Serum homocysteine levels and mortality in outpatients with or without coronary artery disease: an observational study.
- The Lescol Intervention Prevention Study (LIPS): start all patients on statins early after PCI.
- Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohort.
- Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy.
- Importance of high-density lipoprotein cholesterol and triglyceride levels in coronary heart disease.
- Statins do not meet expectations for lowering low-density lipoprotein cholesterol levels when used in clinical practice.
- A truly deadly quartet: obesity, Hypertension, hypertriglyceridemia, and hyperinsulinemia.
- Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine.
- Elevated fibrinogen and homocysteine levels enhance the risk of mortality in patients from a high-risk preventive cardiology clinic.
- Routine statin treatment after acute coronary syndromes?
- Serum testosterone associates with lower high-density lipoprotein cholesterol in black and white males, 10 to 15 years of age, through lowered apolipoprotein AI and AI...
- Blood glucose concentrations < or = 125 mg/dl and coronary heart disease risk.
- Fibrinogen: associations with cardiovascular events in an outpatient clinic.
- Statins in acute coronary syndromes: start them in the hospital.
- Platelet aggregation unchanged by lipoprotein-associated phospholipase A2 inhibition: results from an in vitro study and two randomized phase I trials.
- Preliminary guidelines for the evaluation and management of dyslipidemia in adults infected with human immunodeficiency virus and receiving antiretroviral therapy: Rec...
- Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of...
- C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s.
- Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.
- Treatment of severe familial hypertriglyceridemia during pregnancy with very-low-fat diet and n-3 fatty acids.
- Prevention of cardiovascular diseases. Coronary artery disease, congestive heart failure, and stroke.
- Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fat...
- Low density lipoprotein modulation of porcine coronary artery contractile response to histamine.
- Once-daily, extended-release gemfibrozil in patients with dyslipidemia. The Lopid SR Work Group I.
- C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation.
- Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.
- Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined Hyperlipidemia.
- Indexes of obesity and comparisons with previous national survey data in 9- and 10-year-old black and white girls: the National Heart, Lung, and Blood Institute Growth...
- Obesity and high-density lipoprotein cholesterol in black and white 9- and 10-year-old girls: The National Heart, Lung, and Blood Institute Growth and Health Study.
- Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of Hyperlipidemia.
- Raising high-density lipoprotein cholesterol with niacin and fibrates: a comparative review.
- Comparison of cardiovascular risk and lipid profiles in patients undergoing aortic valve surgery versus those undergoing coronary artery bypass grafting.
- Lipoprotein(a) associated with coronary artery disease in older women: age and gender analysis.
- Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis.
- HDL cholesterol level predicts survival in men after coronary artery bypass graft surgery: 20-year experience from The Cleveland Clinic Foundation.
- Rational approach to pharmacologic reduction of cholesterol levels in children.
- Hyperlipidemia and pancreatitis during pregnancy in two sisters with a mutation in the lipoprotein lipase gene.
- The conjoint trait of low high-density lipoprotein cholesterol and high triglycerides in adolescent black and white males.
- Lipid-lowering therapy for average lipid levels: the CARE trial.
- Effects of regular and extended-release gemfibrozil on plasma lipoproteins and apolipoproteins in hypercholesterolemic patients with decreased HDL cholesterol levels.
- Lipoprotein and apolipoprotein differences in black and white girls. The National Heart, Lung, and Blood Institute Growth and Health Study.
- Higher triglycerides, lower high-density lipoprotein cholesterol, and higher systolic blood pressure in lipoprotein lipase-deficient heterozygotes. A preliminary report.
- Preventive cardiology: whose job is it? Who will pay for it? What is the best strategy?
- Male-female differences in the relationship between obesity and lipids/lipoproteins.
- How deadly is the "deadly quartet"? A post-CABG evaluation.
- Estradiol and testosterone effects on lipids in black and white boys aged 10 to 15 years.
- Usefulness of providing physicians the results of risk factor assessments and treatment recommendations at discharge after coronary artery bypass grafting.
- Relation of serum triglyceride levels to survival after coronary artery bypass grafting.
- Cardiac rehabilitation participation patterns in a large, tertiary care center: evidence for selection bias.
- Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway.
- Where to draw the line using statins: lessons from 4S to AFCAPS/TexCAPS.
- Homocysteine and lipoprotein(a) interact to increase CAD risk in young men and women.
- Serum glutathione in adolescent males predicts parental coronary heart disease.
- Sex and race differences in cardiovascular disease risk factor changes in schoolchildren, 1975-1990: the Princeton School Study.
- Overweight, fat patterning, and cardiovascular disease risk factors in black and white boys.
- Overweight, fat patterning, and cardiovascular disease risk factors in black and white girls: The National Heart, Lung, and Blood Institute Growth and Health Study.
- Association of body fat distribution and cardiovascular risk factors in children and adolescents.
- Triglycerides as a risk factor for coronary artery disease.
- From heart surgery to prevention.
- Sex hormones and lipoproteins in adolescent male offspring of parents with premature coronary heart disease and a control group.
- Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia.
- The low HDL cholesterol/high triglyceride trait.
- The psychological functioning of children with hypercholesterolemia and their families. A preliminary investigation.
- Dietary treatment and growth of hyperchylomicronemic children severely restricted in dietary fat.
- Primary Hyperlipidemia in a pediatric population: classification and effect of dietary treatment.
- The Cincinnati Myocardial Infarction and Hormone Family Study: family resemblance for dehydroepiandrosterone sulfate in control and myocardial infarction families.
- Efficacy of psyllium in reducing serum cholesterol levels in hypercholesterolemic patients on high- or low-fat diets.
- Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.
- Cincinnati myocardial infarction and hormone family study: family resemblance for testosterone in random and MI families.
- Sexual maturation and obesity in 9- and 10-year-old black and white girls: the National Heart, Lung, and Blood Institute Growth and Health Study.
- In vitro color flow, pulsed and continuous wave Doppler ultrasound masking of flow by prosthetic valves.
- Apolipoprotein E-1Harrisburg: a new variant of apolipoprotein E dominantly associated with type III hyperlipoproteinemia.
- Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries.
- Total deficiency of plasma cholesteryl ester transfer protein in subjects homozygous and heterozygous for the intron 14 splicing defect.
- Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency.
- A delayed-addition enzyme immunoassay for the relative cholesteryl ester transfer protein mass in patients with deficient plasma cholesteryl ester transfer activity.
- Perspectives on cholesterol screening programs for children.
- Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.
- Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-dens...
Schools
Boston University School Of Medicine
Michael Reese Hospital and Med Center
National Heart Lung and Blood Institute Nih
Duke University
Conditions Treated
- Hyperlipidemia
- Hypertension
Doctors Specialties
- Cardiology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Personal Choice PPO
- Regional Pref Network EPO
- Regional Pref Network HMO
- Regional Pref Network HMO+
- Regional Pref Network POS+
- Regional Pref Network PPO
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Coventry Health America PPO
- Coventry Health Care of Delaware PPO
- Emblem Health
- First Health (Coventry Health Care) PPO
- Geisinger Health Plan
- Community Blue PPO
- Direct Access
- Horizon Blue Cross Blue Shield HMO
- Horizon Blue Cross Blue Shield POS
- Horizon Blue Cross Blue Shield PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicare MCR
- MultiPlan PPO
- Freedom Plan
- QualCare HMO
- QualCare PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Duke University Hospital -
Boston University School of Medicine
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
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