Physician
Family Medicine
Dr. Deborah A. Young, MD
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Deborah Young works in the field of Family Medicine. He graduated from Rutgers Robert Wood Johnson Medical School. Rutgers Robert Wood Johnson Medical School has a rank of 74 in research and a 67 in primary care He has 1 awards "Meaningful Use Stage 1 Certification". Deborah Young is a published doctor. He has 31 papers published. The most current publication "Ocular lens NAD kinase: partial purification and metabolic implications." He is registered with Medicare and accepts Medicare payments.
Publications
- Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis.
- Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells.
- IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis.
- IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.
- Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.
- IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.
- DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
- The IL-21 receptor augments Th2 effector function and alternative macrophage activation.
- Autoreactive T cells mediate NK cell degeneration in autoimmune disease.
- Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.
- IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.
- IL-21 induces the apoptosis of resting and activated primary B cells.
- IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity.
- Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.
- IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
- CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
- Knockdown and overexpression of NR1 modulates NMDA receptor function.
- AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.
- IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
- Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice.
- Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.
- Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
- mTOR--beyond transplantation.
- Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cyno...
- Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
- In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
- IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice.
- IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
- IL-21 receptor is critical for the development of memory B cell responses.
- Ocular lens NAD kinase: partial purification and metabolic implications.
Schools
University of Medicine And Dentistry of New Jersey Robert Wood Johnson Medical School
Thomas Jefferson University Hospital
Thos Jefferson University Hospital
Doctors Specialties
- Family Medicine
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- American Republic
- Personal Choice PPO
- Assurant Health
- Blue Card PPO
- Capital Blue Cross
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- Coventry Health America PPO
- Emblem Health
- First Health (Coventry Health Care) PPO
- HealthPartners
- Community Blue PPO
- Choice Care PPO
- Keystone Health Plan East HMO
- Medicaid
- Medicare MCR
- United Healthcare
- Universal American
Awards
- Meaningful Use Stage 1 Certification
Education
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Thomas Jefferson University -
Rutgers Robert Wood Johnson Medical School
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