Physician
Hematology
Dr. David V. Christianson, DDS
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David Christianson practices Hematology. He researched medicine at University of Oklahoma College of Medicine. He received 1 awards: "CMS Meaningful Use Stage 1 Certification". David Christianson is a published doctor as well. He has 100 publications published. The latest was: Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism.
Publications
- General Base-General Acid Catalysis in Human Histone Deacetylase 8.
- Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
- Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
- Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster.
- Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
- Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
- Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
- Underestimating the frequency, strength and cost of antipredator responses with data from GPS collars: an example with wolves and elk.
- Formiminoglutamase from Trypanosoma Cruzi Is An Arginase-Like Manganese Metalloenzyme.
- 1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis.
- Synthesis and evaluation of Nâ¸-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase.
- Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
- Conserving large populations of lions - the argument for fences has holes.
- Unexpected Reactivity of 2-Fluorolinalyl Diphosphate in the Active Site of Crystalline 2-Methylisoborneol Synthase.
- Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
- Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17?-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-...
- Energetically unfavorable amide onformations for N6-Acetyllysine side chains in refined protein structures.
- Ecosystem scale declines in elk recruitment and population growth with wolf colonization: a before-after-control-impact approach.
- Predation risk affects reproductive physiology and demography of elk.
- Glucocorticoid stress hormones and the effect of predation risk on elk reproduction.
- The contribution of halogen atoms to protein-ligand interactions.
- Environmental and genetic factors that contribute to Escherichia coli K-12 biofilm formation.
- Another catalytic triad?
- Purification and characterization of Klebsiella aerogenes UreE protein: a nickel-binding protein that functions in urease metallocenter assembly.
- Combinatorial materials research applied to the development of new surface coatings VII: an automated system for adhesion testing.
- Combinatorial materials research applied to the development of new surface coatings IV. A high-throughput bacterial biofilm retention and retraction assay for screenin...
- Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement.
- Combinatorial materials research applied to the development of new surface coatings III. Utilisation of a high-throughput multiwell plate screening method to rapidly a...
- Modeling the uncleaved serpin antichymotrypsin and its chymotrypsin complex.
- Is the binding of beta-amyloid protein to antichymotrypsin in Alzheimer plaques mediated by a beta-strand insertion?
- Crystallization and atomic resolution X-ray diffraction analysis of antichymotrypsin variants.
- Biological recognition of phosphate and sulfate.
- Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A.
- Crystallographic studies of azide binding to human carbonic anhydrase II.
- Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.
- Structural properties of human carbonic anhydrase II at pH 9.5.
- Structural chemistry and biology of manganese metalloenzymes.
- Structural consequences of redesigning a protein-zinc binding site.
- Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
- Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop.
- Active-site engineering of carbonic anhydrase and its application to biosensors.
- Structural biology of zinc.
- Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II.
- Engineering an anion-binding Cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
- X-ray crystallographic studies of mammalian carbonic anhydrase isozymes.
- Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes.
- Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin.
- Engineering the hydrophobic pocket of carbonic anhydrase II.
- Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a ...
- Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
- Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.
- Structure determination of aquomet porcine hemoglobin at 2.8 A resolution.
- Hydrogen bond stereochemistry in protein structure and function.
- Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
- Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II.
- Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.
- Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.
- Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.
- Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase.
- Ribonuclease P protein structure: evolutionary origins in the translational apparatus.
- Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism.
- Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase.
- Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site.
- Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor.
- Evolution of the arginase fold and functional diversity.
- Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes.
- Arginase: a binuclear manganese metalloenzyme.
- A new chromophoric assay for arginase activity.
- Arginase-boronic acid complex highlights a physiological role in erectile function.
- Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V.
- Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
- Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.
- Crystallization and preliminary X-ray diffraction analysis of recombinant pentalenene synthase.
- Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
- Crystallization and oligomeric structure of rat liver arginase.
- Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
- Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
- Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
- Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
- Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
- Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
- Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus c...
- Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
- Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
- Structural analysis of inhibitor binding to human carbonic anhydrase II.
- Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
- Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
- Structure of a unique binuclear manganese cluster in arginase.
- Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
- Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
- Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
- X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
- Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.
- Identification of two hydrophobic patches in the active-site Cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the devel...
- Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
- Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.
- Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.
- Endothelial arginase II: a novel target for the treatment of atherosclerosis.
- Unearthing the roots of the terpenome.
Schools
Oregon Health amp Science University School Of Dentistry
Palmetto Health Richland Hospital
Brigham Young University
Procedures Preformed
- Endodontic Retreatment
- Root Canal
- Single Visit Root Canals
- Surgical Procedures
Conditions Treated
- Cavity
- Tooth Abscess
- Tooth Avulsion
- Tooth Decay
- View All
Doctors Specialties
- Endodontics
- Hematology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of Missouri-Columbia -
University of Oklahoma College of Medicine
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