Professor of Stem Cell and Regenerative Biology, FAS - Harvard
Internal Medicine
Dr. David T. Scadden Jr., MD
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Dr. David T. Scadden Jr. is an expert in the field of Internal Medicine. He attended Case Western Reserve University School of Medicine. He received 3 awards: "Regional Top Doctor", "Elected Member" and "Whos Who in Medicine and Healthcare". David T. Scadden Jr., MD is a published doctor. He published 102 publications, including: 'Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-B inflammatory pathway.'
Publications
- A hostel for the hostile: the bone marrow niche in hematologic neoplasms.
- Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model.
- Global transcriptome analysis of T-competent progenitors in the bone marrow.
- Mesenchymal Cell Contributions to the Stem Cell Niche.
- Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
- Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
- Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
- Blood loses it when nerves go bad.
- Cellular thrust and parry in the leukemic niche.
- Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.
- Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
- Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.
- Deep diving in the blood stem cell-ome.
- SnapShot: The Hematopoietic Stem Cell Niche.
- Bayesian approach to single-cell differential expression analysis.
- Tic-TACs: Refreshing Hair Growth.
- Direct measurement of local oxygen concentration in the bone marrow of live animals.
- Nice Neighborhood: Emerging Concepts of the Stem Cell Niche.
- Bone's dark side: mutated osteoblasts implicated in leukemia.
- Stress Hematopoiesis Is Regulated by the Krüppel-Like Transcription Factor ZBP-89.
- The bone marrow niche for haematopoietic stem cells.
- Genome-wide Map of Nuclear Protein Degradation Shows NCoR1 Turnover as a Key to Mitochondrial Gene Regulation.
- Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
- Blood scent.
- Differential regulation of myeloid leukemias by the bone marrow microenvironment.
- Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia.
- Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
- Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
- In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling.
- Differential stem- and progenitor-cell trafficking by prostaglandin E2.
- Xist RNA is a potent suppressor of hematologic cancer in mice.
- The hematopoietic stem cell niche--home for friend and foe?
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ?-catenin.
- In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.
- Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neopla...
- Myelopoiesis is regulated by osteocytes through Gsñ-dependent signaling.
- Rethinking stroma: lessons from the blood.
- The secrets of the bone marrow niche: Metabolic priming for AML.
- Deconstructing the complexity of a microenvironmental niche.
- A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-a...
- The hematopoietic stem cell niche.
- NF-Y is necessary for hematopoietic stem cell proliferation and survival.
- Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
- AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
- Differential niche and Wnt requirements during acute myeloid leukemia progression.
- The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.
- Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage specification.
- Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.
- Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
- Biomimetic platforms for human stem cell research.
- Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen.
- A microRNA regulating adult hematopoietic stem cells.
- MicroRNA miR-125a controls hematopoietic stem cell number.
- Stem cells and DNA damage: persist or perish?
- Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
- The HSC niche concept has turned 31. Has our knowledge matured?
- CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.
- The leukemic stem cell niche: current concepts and therapeutic opportunities.
- Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma.
- Role of the osteoblast lineage in the bone marrow hematopoietic niches.
- Forward RNAi screens in primary human hematopoietic stem/progenitor cells.
- p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.
- Homing of hematopoietic cells to the bone marrow.
- GATA-2 regulates granulocyte-macrophage progenitor cell function.
- Will stem cells finally deliver?
- Divided within: heterogeneity within adult stem cell pools.
- Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.
- Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.
- Evolving concepts on the microenvironmental niche for hematopoietic stem cells.
- Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.
- MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.
- Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
- Differential H3K4 methylation identifies developmentally poised hematopoietic genes.
- Stem-cell ecology and stem cells in motion.
- Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.
- Prospects for stem cell-based therapy.
- Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
- Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.
- Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.
- Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium stud...
- The weight of cell identity.
- Analysis of the hematopoietic stem cell niche.
- Limiting factors in murine hematopoietic stem cell assays.
- Stem cells remember their grade.
- A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.
- Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functiona...
- Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
- Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro.
- Therapeutic targeting of a stem cell niche.
- Primitive hematopoietic cells resist HIV-1 infection via p21.
- AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
- Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy.
- Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.
- Embryonic stem cells make human T cells.
- Osteoclasts eat stem cells out of house and home.
- The hematopoietic stem cell in its place.
- Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
- Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells a...
- HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency.
- Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm.
- Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Schools
Case Western Reserve University School of Medicine
Brigham Womens HospHarvard
Brigham Womens Hospital
Brigham Womens HospDana Fa
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
- Internal Medicine
Accepted Insurances
Awards
- Regional Top Doctor
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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Tufts Medical Center -
Brigham and Women's Hospital -
Case Western Reserve University School of Medicine
Hospital
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Massachusetts General Hospital
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