Assistant Professor, Pharmacology, University of Iowa Roy J. and Lucille A. Carver COM
Family Medicine
Dr. David R. Sheff, MD
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David R. Sheff, MD works in the field of Family Medicine. He over the years received 1 awards: "Patient-Centered Medical Home Recognition Program". David Sheff is a published MD. He has 25 papers published. The most current publication "Cloning, expression, and localization of a novel gamma-adaptin-like molecule."
Publications
- Immunostaining: detection of signaling protein location in tissues, cells and subcellular compartments.
- Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi.
- Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.
- RalA and RalB differentially regulate development of epithelial tight junctions.
- Novel positron emission tomography tracer distinguishes normal from cancerous cells.
- Passage through the Golgi is necessary for Shiga toxin B subunit to reach the endoplasmic reticulum.
- Deciliation is associated with dramatic remodeling of epithelial cell junctions and surface domains.
- Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome.
- Recycling endosomes of polarized epithelial cells actively sort apical and basolateral cargos into separate subdomains.
- Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics.
- Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging.
- Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways.
- Endosomes as a route for drug delivery in the real world.
- Golgi biogenesis in Toxoplasma gondii.
- Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes.
- The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions.
- Cloning, expression, and localization of a novel gamma-adaptin-like molecule.
- Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component epsilon-COP.
- Biochemical heterogeneity and phosphorylation of coatomer subunits.
- Cytoplasmic coat proteins involved in endosome function.
- Isolation and characterization of the rat liver actin N-acetylaminopeptidase.
- Amino-terminal processing of actins mutagenized at the Cys-1 residue.
- Unusual metabolism of the yeast actin amino terminus.
- Identification of N-acetylmethionine as the product released during the NH2-terminal processing of a pseudo-class I actin.
Schools
University of Ia Roy J amp L Carver Com
Doctors Specialties
- Family Medicine
Accepted Insurances
Awards
- Patient-Centered Medical Home Recognition Program
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