University of Michigan Multiple Sclerosis Center
Neurology
Dr. David N. Irani, MD
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David N. Irani, MD is an expert in the field of Neurology. He went to medical school at University of Michigan Medical School. He has 1 awards "CMS Meaningful Use Stage 1 Certification". David N. Irani, MD is a published doctor and has 45 publications published. The lastest was: 'The susceptibility of mice to immune-mediated neurologic disease correlates with the degree to which their lymphocytes resist the effects of brain-derived gangliosides.' Doctor David N. Irani, MD accepts all Medicare patients.
Publications
- The conundrum of interferon-β non-responsiveness in relapsing-remitting Multiple sclerosis.
- Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development.
- Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS.
- Novel indole-2-carboxamide compounds are potent broad spectrum antivirals active against western equine encephalitis virus in vivo.
- Type-I interferons suppress microglial production of the lymphoid chemokine, CXCL13.
- Optimization of Novel Indole-2-carboxamide Inhibitors of Neurotropic Alphavirus Replication.
- Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: Implications for how viral infections might trigger Multiple sclerosis ex...
- The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed Central nervous system.
- Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.
- Aseptic meningitis and viral myelitis.
- The opioid receptor antagonist, naloxone, protects spinal motor neurons in a murine model of alphavirus encephalomyelitis.
- Neuroprotective interventions targeting detrimental host immune responses protect mice from fatal alphavirus encephalitis.
- Cleavage of cystatin C in the cerebrospinal fluid of patients with Multiple sclerosis.
- 14-3-3 protein in CSF: an early predictor of SIV CNS Disease.
- Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitoToxicity.
- Glutamate receptor antagonists protect from virus-induced neural degeneration.
- Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.
- Diagnosis and prevention of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob Disease.
- The classic and variant forms of Creutzfeldt-Jakob Disease.
- West Nile virus encephalitis in the United States.
- BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis.
- Targeting CXCL13 During Neuroinflammation.
- Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by Inflammatory cytokines and correlate with paralysis severity during experiment...
- Discovery of potent broad spectrum antivirals derived from marine actinobacteria.
- Postmortem observations on beta-glucuronidase deficiency presenting as hydrops fetalis.
- Heterogeneity in cellular antigen retention structures.
- Brain-derived gangliosides induce cell cycle arrest in a murine T cell line.
- Relapse in Guillain-Barré Syndrome after treatment with human immune globulin.
- Central nervous system inflammation: can''t live with it, can''t live without it.
- 14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis.
- Isolation of Brain parenchymal lymphocytes for flow cytometric analysis. Application to acute viral encephalitis.
- Interferon beta in Multiple sclerosis: is IL-12 suppression the key?
- The susceptibility of mice to immune-mediated neurologic Disease correlates with the degree to which their lymphocytes resist the effects of brain-derived gangliosides.
- Immune reconstitution Inflammatory syndrome in the CNS of HIV-infected patients.
- Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells.
- Regulation of lymphocyte homing into the Brain during viral encephalitis at various stages of infection.
- Regulation of T cell responses during Central nervous system viral infection.
- The immune response in viral encephalitis.
- Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus Dementia.
- Regulation of Brain-derived T cells during acute central nervous system inflammation.
- Activation of divergent neuronal cell death pathways in different target cell populations during neuroadapted sindbis virus infection of mice.
- How much control does the Brain exert over the immune system?
- The Inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acu...
- Characteristics and reversibility of Dementia in Normal Pressure Hydrocephalus.
Schools
University Of Michigan Medical School
Johns Hopkins Hospital
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Alzheimer's Disease
- Anterior Horn Disease
- Ataxia
- Bell's Palsy
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Doctors Specialties
- Neurology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Johns Hopkins University -
St Joseph Mercy Livingston Hospital -
University of Michigan Medical School
Hospital
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University of Michigan Hospitals and Health Centers
Drug Facts
| NPI NUMBER | 1558317404 | |
| NPPES Provider LastName | IRANI | |
| NPPES Provider FirstName | DAVID | |
| NPPES Provider ZIPCode | 481095322 | |
| NPPES Provider State | MI | |
| Specialty Description | Neurology | |
| Total Claim Count | 851.0 | |
| Distinct Opioid Count | 2.0 | |
| Opioid Claim Count | 31.0 | |
| Percent Opioid Claims | 3.64 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1558317404 |
| Last Name Of The Provider | IRANI |
| First Name Of The Provider | DAVID |
| View All |
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