Professor, Pediatrics, Oregon Health and Science University School of Medicine
Medical Genetics
Dr. David M. Koeller, MD
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David Koeller is an expert in the field of Medical Genetics. He researched medicine at University of Illinois College of Medicine. Doctor David M. Koeller, MD has written publications. He has 57 publications published with PubMed. The lastest publication is: 'Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: the mouse homologs of genes responsible for glutaric acidemia type II in human.'
Publications
- Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical features and long term outcomes in 16 patients diagnosed worldwide.
- Acute lysine overload provokes protein oxidative damage and reduction of antioxidant defenses in the brain of infant glutaryl-CoA dehydrogenase deficient mice: A role ...
- Association of a Genetic Variant of Carnitine Palmitoyltransferase 1A with Infections in Alaska Native Children.
- Neurodevelopmental and cognitive behavior of glutaryl-CoA dehydrogenase deficient knockout mice.
- Disruption of brain redox homeostasis in glutaryl-CoA dehydrogenase deficient mice treated with high dietary lysine supplementation.
- Impaired fasting tolerance among Alaska native children with a common carnitine palmitoyltransferase 1A sequence variant.
- Glutaric aciduria type 1 metabolites impair the succinate transport from astrocytic to neuronal cells.
- Diagnosis and management of glutaric aciduria type I - revised recommendations.
- Prevalence and distribution of the c.1436C?T sequence variant of carnitine palmitoyltransferase 1A among Alaska Native infants.
- Evidence for an association between infant mortality and a carnitine palmitoyltransferase 1A genetic variant.
- Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
- Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency.
- Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A.
- Pathomechanisms of neurodegeneration in glutaryl-CoA dehydrogenase deficiency.
- Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric a...
- MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress.
- Genomic organization of ATOX1, a human copper chaperone.
- Biochemical, pathologic and behavioral analysis of a mouse model of glutaric acidemia type I.
- Apparent decreased energy requirements in children with organic acidemias: preliminary observations.
- Analysis of the expression of murine glutaryl-CoA dehydrogenase: in vitro and in vivo studies.
- Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A).
- Putting pieces together for the future. Interview by Bill Childs.
- Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: the mouse homologs of genes responsible for glutaric acidemia type II in human.
- Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
- Identification of an RNA binding site for human thymidylate synthase.
- Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.
- Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3'' UTR and does not involve poly(A) tail shortening.
- Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene.
- Failure of D-thyroxine to increase fetal hemoglobin levels in normal and anemic baboons.
- Evaluation of the structure function relationships of MHC class I antigens by molecular genetic techniques.
- A model for the structure and functions of iron-responsive elements.
- Clinical, metabolic, and antibody responses of adult volunteers to an investigational vaccine composed of pertussis toxin inactivated by hydrogen peroxide.
- The Munich Personality Test (MPT)--a short questionnaire for self-rating and relatives'' rating of personality traits: formal properties and clinical potential.
- Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3'' untranslated region of the mRNA.
- A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
- Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
- Introduction of H-2Dd determinants into the H-2Ld antigen by site-directed mutagenesis.
- Hypertension and renal failure in a patient with tuberous sclerosis.
- Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
- Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.
- Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.
- Fetal hemoglobin in neonatal anemia.
- Post-transcriptional regulation of the human transforming growth factor-beta 1 gene.
- Save yourself! The importance of disaster recovery.
- Challenges for basic research in glutaryl-CoA dehydrogenase deficiency.
- Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I.
- Animal models for glutaryl-CoA dehydrogenase deficiency.
- Excitotoxicity and bioenergetics in glutaryl-CoA dehydrogenase deficiency.
- The mitochondrial ABC transporter Atm1p functions as a homodimer.
- Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1.
- 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.
- Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I).
- Lysine intake and neurotoxicity in glutaric aciduria type I: towards a rationale for therapy?
- Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for ne...
- The role of the mitochondrion in cellular iron homeostasis.
- Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.
Schools
University of Illinois At Chicago College of Medicine
University Of Minnesota
University of Washington
Doctors Specialties
- Clinical Biochemical Genetics
- Pediatrics
- Medical Genetics
Accepted Insurances
Education
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University of Illinois College of Medicine
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