Professor of Medicine, University Mass School of Medicine
Endocrinology
Dr. David M. Harlan, MD
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Dr. David M. Harlan is an expert in the field of Endocrinology. He went to medical school at Duke University School of Medicine. Duke University School of Medicine is a top medical college. Duke University School of Medicine is ranked 8 in research and 29 in primary care medicine He over the years received 2 awards: "Meaningful Use Stage 1 Certification" and "Elected Member". David Harlan is a published physician. He published 100 publications, including: 'Low dose poly I:C prevents diabetes in the diabetes prone BB rat.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Pathogenic CD4 T cells in type 1 Diabetes recognize epitopes formed by peptide fusion.
- The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
- Long-Term Immunosuppression After Solitary Islet Transplantation Is Associated With Preserved C-Peptide Secretion for More Than a Decade.
- Response to comment on sarkar et Al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 Diabetes. Diabetes care 2014;37:666-670.
- Differences in the Management of Type 1 Diabetes Among Adults Under Excellent Control Compared With Those Under Poor Control in the T1D Exchange Clinic Registry.
- The Clinical Center's Blood Glucose Management Service: A Story in Quality Integrated Care.
- Humanized mice for the study of type 1 and type 2 Diabetes.
- Metabolic function of a suboptimal transplanted islet mass in non-human primates on rapamycin monotherapy.
- Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 Diabetes.
- Comment on: Keenan et al. (2010) residual insulin production and pancreatic ß-Cell turnover after 50 years of Diabetes: Joslin Medalist Study. Diabetes 20...
- Infant formula, autoimmune triggers, and type 1 Diabetes.
- Diabetes and cancer: a consensus report.
- Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 Diabetes.
- Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.
- Counterpoint: clinical islet transplantation: not ready for prime time.
- Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 Diabetes.
- Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune Diabetes.
- Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.
- Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic Manifestations by inactivating Vhl in specific pancreatic cell populations.
- Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune Diabetes in mice.
- Cytotoxic T cell-mediated Diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
- T cell-directed therapies: lessons learned and future prospects.
- Assessment of islet function following islet and pancreas transplantation.
- Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.
- Immune intervention with anti-CD3 in Diabetes.
- Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection Without tolerance.
- A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after o...
- Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging.
- Increased insulin translation from an insulin splice-variant overexpressed in Diabetes, obesity, and insulin resistance.
- Islet transplantation and the challenges of treating type 1 Diabetes.
- Pancreatic islet transplantation.
- Pulmonary angiography for the diagnosis of thromboembolic events in the non-human primate.
- Challenges facing islet transplantation for the treatment of type 1 Diabetes mellitus.
- Islet transplantation as a treatment for Diabetes.
- Resistin serum levels in type 1 Diabetes pre- and post-islet transplantation.
- Insulin secretion in type 1 Diabetes.
- Gene-altered islets for transplant: giant leap or small step?
- Induction of Diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin.
- Survival after pancreas transplantation in patients with Diabetes and preserved kidney function.
- Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
- Benefits and risks of solitary islet transplantation for type 1 Diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience.
- State of the art: islet transplantation for the cure of type 1 Diabetes mellitus.
- Sirolimus-induced interstitial pneumonitis in an islet transplant recipient.
- Resistin is expressed in pancreatic islets.
- Results from a human Renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).
- Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
- Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotrans...
- Ex vivo culture With human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow.
- Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression.
- Combination induction therapy With monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.
- Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.
- Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway.
- A proinsulin gene splice variant With increased translation efficiency is expressed in human pancreatic islets.
- Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.
- Immune response to engineered tissues and cells: breakout session summary.
- Islet cell allotransplantation as a model system for a bioengineering approach to reparative medicine: immunological concerns.
- Immunological concerns With bioengineering approaches.
- Anti-CD3 monoclonal antibody in new-onset type 1 Diabetes mellitus.
- Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.
- Radiologic aspects of islet cell transplantation.
- Hematopoietic stem cell transplantation prevents Diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established.
- Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers.
- Peak stimulated insulin secretion is associated With specific changes in gene expression profiles in sporadic insulinomas.
- Effects of dose and duration of anti-CD154 antibody therapy in preventing Renal allograft rejection in a nonhuman primate model.
- Preincubation With endothelial cell monolayers increases gene transfer efficiency into human bone marrow CD34(+)CD38(-) progenitor cells.
- The implications of practice guidelines for physician medical malpractice liability.
- Current advances and travails in islet transplantation.
- Islet transplantation: where do we stand now?
- Transduction of rat pancreatic islets with pseudoTyped adeno-associated virus vectors.
- Pancreatic islet cell therapy for type I Diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
- Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin.
- The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
- Insulinomas and expression of an insulin splice variant.
- Effects of combined treatment With CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation.
- Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated Diabetes.
- Kidney transplantation With rabbit antithymocyte globulin induction and sirolimus monotherapy.
- Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate Renal allotransplant model.
- Ethnicity greatly influences cytokine gene polymorphism distribution.
- Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation.
- Low dose streptozotocin-induced Diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent.
- Effect of indomethacin on coronary vascular response to increased myocardial oxygen consumption.
- Screening for breast cancer among New Jersey women.
- The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.
- Sinus histiocytosis With massive lymphadenopathy. Occurrence in identical twins With retroperitoneal disease.
- A factor in food which impairs Na+-K+-ATPase in vitro.
- Transitional blood flow zones between ischemic and nonischemic myocardium in the awake dog. Analysis based on distribution of the intramural vasculature.
- Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop Diabetes due to a breakdown of T-...
- A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune Diabetes of early onset in transgenic mice.
- Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion.
- Very-low-dose streptozotocin induces Diabetes in insulin promoter-mB7-1 transgenic mice.
- Protection against lethal toxic shock by targeted disruption of the CD28 gene.
- Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2).
- Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.
- Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts.
- CD28 co-receptor signal transduction in T-cell activation.
- CTLA4-Ig and anti-CD40 ligand prevent Renal allograft rejection in primates.
- Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4.
- Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling.
- Low dose poly I:C prevents Diabetes in the Diabetes prone BB rat.
Schools
Duke University
Duke University Med Center
Conditions Treated
- AdRenal Insufficiency
- Diabetes Mellitus, Secondary
- Diabetes Type 1
- Diabetes Type 2
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Meaningful Use Stage 1 Certification
- Elected Member
Education
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Duke University Hospital -
Duke University School of Medicine
Hospital
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UMass Memorial Medical Center
Drug Facts
| NPI NUMBER | 1083737951 | |
| NPPES Provider LastName | HARLAN | |
| NPPES Provider FirstName | DAVID | |
| NPPES Provider ZIPCode | 016550002 | |
| NPPES Provider State | MA | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 292.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1083737951 |
| Last Name Of The Provider | HARLAN |
| First Name Of The Provider | DAVID |
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